Interaction Studies of a Novel, Water-Soluble and Anti-Cancer Palladim(II) Complex with Calf Thymus DNA

A new tin(IV) corrole, 5,10,15-tris(4-methoxycarbonylphenyl) corrole tin(IV) (1-Sn) was synthesized and characterized. The DNA binding, photocleavage and anti-cancer activity were studied and compared with its free-base. The interaction of 1-Sn and its free-base 1 with calf thymus DNA had been investigated by spectroscopic methods, viscosity measurements and molecular docking analysis. The results revealed that 1-Sn and 1 could interact with calf thymus DNA via an outside groove binding mode. Furthermore, although 1 displayed no photonuclease activity, 1-Sn exhibited good photonuclease activity as indicated by agarose gel electrophoresis, and superoxide anion might be the active intermediate for the DNA scission. Finally, 1 was nontoxic but 1-Sn displayed cytotoxicity towards A549 tumor cell lines.

Download Full-text

Interaction of a synthesized pyrene based fluorescent probe with CT-DNA: spectroscopic, thermodynamic and molecular modeling studies

RSC Advances ◽

10.1039/c6ra20267e ◽

2016 ◽

Vol 6 (96) ◽

pp. 93335-93342 ◽

Cited By ~ 7

Author(s):

Soumen Ghosh ◽

Abdulla Al Masum ◽

Aniruddha Ganguly ◽

Md. Akhtarul Alam ◽

Md. Maidul Islam ◽

...

Keyword(s):

Molecular Modeling ◽

Fluorescent Probe ◽

Water Soluble ◽

Calf Thymus Dna ◽

Modeling Studies ◽

Calf Thymus ◽

Molecular Modeling Studies ◽

Ct Dna

The present study demonstrates the synthesis of a new pyrene based water soluble fluorescent probe and its interaction with Calf-thymus DNA.

Download Full-text

Novel Bimetallic Complexes of Copper, Nickel and Manganese Derived from the Cobalt(III) Complex and their Interaction Studies with Calf Thymus DNA

Transition Metal Chemistry ◽

10.1007/s11243-005-6333-z ◽

2005 ◽

Vol 30 (8) ◽

pp. 998-1007 ◽

Cited By ~ 3

Author(s):

Sartaj Tabassum ◽

Irshad ul Haq Bhat

Keyword(s):

Calf Thymus Dna ◽

Bimetallic Complexes ◽

Copper Nickel ◽

Interaction Studies ◽

Calf Thymus

Download Full-text

Interaction studies between a 1,10-phenanthroline adduct of palladium(II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2010.05.029 ◽

2010 ◽

Vol 77 (1) ◽

pp. 312-318 ◽

Cited By ~ 39

Author(s):

Hassan Mansouri-Torshizi ◽

Maryam Saeidifar ◽

Adeleh Divsalar ◽

Ali.Akbar Saboury

Keyword(s):

In Vitro Study ◽

Vitro Study ◽

Calf Thymus Dna ◽

Interaction Studies ◽

Calf Thymus

Download Full-text

Effects of light-activated diazido-Pt IV complexes on cancer cells in vitro

Philosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences ◽

10.1098/rsta.2012.0118 ◽

2013 ◽

Vol 371 (1995) ◽

pp. 20120118 ◽

Cited By ~ 26

Author(s):

Patrick J. Bednarski ◽

Katharina Korpis ◽

Aron F. Westendorf ◽

Steffi Perfahl ◽

Renate Grünert

Keyword(s):

Cell Death ◽

Cancer Cells ◽

Calf Thymus Dna ◽

Cross Resistance ◽

Cancer Drug ◽

Cancer Cell Growth ◽

Calf Thymus ◽

Anti Cancer ◽

Cellular Dna

Various Pt IV diazides have been investigated over the years as light-activatable prodrugs that interfere with cell proliferation, accumulate in cancer cells and cause cell death. The potencies of the complexes vary depending on the substituted amines (pyridine=piperidine>ammine) as well as the coordination geometry ( trans diazide> cis ). Light-activated Pt IV diazides tend to be less specific than cisplatin at inhibiting cancer cell growth, but cells resistant to cisplatin show little cross-resistance to Pt IV diazides. Platinum is accumulated in the cancer cells to a similar level as cisplatin, but only when activated by light, indicating that reactive Pt species form photolytically. Studies show that Pt also becomes attached to cellular DNA upon the light activation of various Pt IV diazides. Structures of some of the photolysis products were elucidated by LC–MS/MS; monoaqua- and diaqua-Pt II complexes form that are reactive towards biomolecules such as calf thymus DNA. Platination of calf thymus DNA can be blocked by the addition of nucleophiles such as glutathione and chloride, further evidence that aqua-Pt II species form upon irradiation. Evidence is presented that reactive oxygen species may be generated in the first hours following photoactivation. Cell death does not take the usual apoptotic pathways seen with cisplatin, but appears to involve autophagy. Thus, photoactivated diazido-Pt IV complexes represent an interesting class of potential anti-cancer agents that can be selectively activated by light and kill cells by a mechanism different to the anti-cancer drug cisplatin.

Download Full-text