scholarly journals Epigenetic Modulation of Gene Expression during Keratinocyte Differentiation

2012 ◽  
Vol 24 (3) ◽  
pp. 261 ◽  
Author(s):  
Seung Ju Back ◽  
Myung Im ◽  
Kyung Cheol Sohn ◽  
Dae Kyoung Choi ◽  
Ge Shi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Keratinocyte Differentiation ◽  
Modulation Of Gene Expression ◽  
Epigenetic Modulation

scholarly journals Hox Genes in Reptile Development, Epigenetic Regulation, and Teratogenesis

2018 ◽  
Vol 157 (1-2) ◽  
pp. 34-45 ◽  
Author(s):  
Rodolfo Martín-del-Campo ◽  
Itzel Sifuentes-Romero ◽  
Alejandra García-Gasca
Keyword(s):  
Gene Expression ◽  
Cell Fate ◽  
Epigenetic Regulation ◽  
Hox Genes ◽  
Present Information ◽  
Modulation Of Gene Expression ◽  
Body Shapes ◽  
Epigenetic Modulation ◽  
Genetic Pool

Reptiles are ancestral organisms presenting a variety of shapes, from the elongated vertebral column of the snake to the turtle dorsalized ribs or retractile neck. Body plans are specified by a conserved group of homeobox-containing genes (Hox genes), which encode transcription factors important in cell fate and vertebral architecture along the anteroposterior axis during embryonic development; thus, dysregulation of these genes may cause congenital malformations, from mild-sublethal to embryonic-lethal. The genetic pool, maternal transfer, and environmental conditions during egg incubation affect development; environmental factors such as temperature, moisture, oxygen, and pollution may alter gene expression by epigenetic mechanisms. Thus, in this review, we present information regarding Hox genes and development in reptiles, including sex determination and teratogenesis. We also present some evidence of epigenetic regulation of Hox genes and the role of the environment in epigenetic modulation of gene expression. So far, the evidence suggests that the molecular instructions encoded by Hox genes to build a snake, a lizard, or a turtle represent the interplay between genome and epigenome after years of evolution, with occasional environmentally induced molecular mistakes leading to abnormal body shapes.

scholarly journals The mitochondrial side of epigenetics

2015 ◽  
Vol 47 (8) ◽  
pp. 299-307 ◽  
Author(s):  
Alessandra Castegna ◽  
Vito Iacobazzi ◽  
Vittoria Infantino
Keyword(s):  
Gene Expression ◽  
Cross Talk ◽  
Cell Function ◽  
Nuclear Gene ◽  
Epigenetic Factors ◽  
Nuclear Gene Expression ◽  
New Findings ◽  
Modulation Of Gene Expression ◽  
Epigenetic Modulation ◽  
Complex Scenario

The bidirectional cross talk between nuclear and mitochondrial DNA is essential for cellular homeostasis and proper functioning. Mitochondria depend on nuclear contribution for much of their functionality, but their activities have been recently recognized to control nuclear gene expression as well as cell function in many different ways. Epigenetic mechanisms, which tune gene expression in response to environmental stimuli, are key regulatory events at the interplay between mitochondrial and nuclear interactions. Emerging findings indicate that epigenetic factors can be targets or instruments of mitochondrial-nuclear cross talk. Additionally, the growing interest into mtDNA epigenetic modifications opens new avenues into the interaction mechanisms between mitochondria and nucleus. In this review we summarize the points of mitochondrial and nuclear reciprocal control involving epigenetic factors, focusing on the role of mitochondrial genome and metabolism in shaping epigenetic modulation of gene expression. The relevance of the new findings on the methylation of mtDNA is also highlighted as a new frontier in the complex scenario of mitochondrial-nuclear communication.

Epigenetic Modulation of Gene Expression by Exercise

2015 ◽  
pp. 85-100 ◽  
Author(s):  
Sataro Goto ◽  
Kyojiro Kawakami ◽  
Hisashi Naito ◽  
Shizuo Katamoto ◽  
Zsolt Radak
Keyword(s):  
Gene Expression ◽  
Modulation Of Gene Expression ◽  
Epigenetic Modulation

scholarly journals Targeted Epigenetic Modulation of Gene Expression in the Brain

2016 ◽  
Vol 36 (36) ◽  
pp. 9283-9285 ◽  
Author(s):  
Evan J. Kyzar ◽  
Ritabrata Banerjee
Keyword(s):  
Gene Expression ◽  
Modulation Of Gene Expression ◽  
Epigenetic Modulation ◽  
The Brain

Epigenetic modulation of gene expression of human leukemia cell lines – induction of cell death and senescence

Neoplasma ◽  
2011 ◽  
Vol 58 (1) ◽  
pp. 35-44 ◽  
Author(s):  
K. ELKNEROVA ◽  
D. MYSLIVCOVA ◽  
Z. LACINOVA ◽  
I. MARINOV ◽  
L. UHERKOVA ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Cell Lines ◽  
Leukemia Cell ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Leukemia Cell Lines ◽  
Modulation Of Gene Expression ◽  
Epigenetic Modulation

scholarly journals The Epigenetics of Normal Pregnancy

2011 ◽  
Vol 6 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Jonathan D Best ◽  
Nessa Carey
Keyword(s):  
Gene Expression ◽  
Cell Fate ◽  
Fetal Development ◽  
Normal Pregnancy ◽  
Epigenetic Changes ◽  
Fetal Health ◽  
Major Interest ◽  
Modulation Of Gene Expression ◽  
Epigenetic Modulation ◽  
Hormonal Signalling

Epigenetic modifications to chromatin are essential for the specification and maintenance of cell fate, enabling the same genome to programme a variety of cellular outcomes. Epigenetic modulation of gene expression is also a critical mechanism by which cells stabilize their responses to environmental stimuli, including both nutritional cues and hormonal signalling. Unsurprisingly, epigenetics is proving to be vitally important in fetal development, and this review addresses our current understanding of the roles of epigenetic regulation in the prenatal phase. It is striking that while there has been a major interest in the intersection of fetal health with epigenetics, there has been relatively little discussion in the literature on epigenetic changes in the pregnant woman, and we attempt to redress this balance, drawing on the fragmented but intriguing experimental literature in this field.

scholarly journals MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells

2010 ◽  
Vol 3 ◽  
pp. GEG.S6144 ◽  
Author(s):  
Cong-Jun Li ◽  
Robert W. Li ◽  
Theodore H. Elsasser
Keyword(s):  
Gene Expression ◽  
Histone Acetylation ◽  
Mirna Expression ◽  
Gene Networks ◽  
Differentially Expressed ◽  
Cellular Functions ◽  
Differentially Expressed Mirnas ◽  
Pathways Analysis ◽  
Modulation Of Gene Expression ◽  
Epigenetic Modulation

We present evidence that butyrate induced histone acetylation regulates miRNA expression. MicroRNA expression microarray profiling revealed that 35 miRNA transcripts are significantly ( P < 0.05) differentially expressed after cells were treated with 10 mM butyrate. Among them, 11 transcripts are differentially expressed very significantly ( P < 0.01). The functional and pathways analysis using MetaCore analytical suite shows differentially expressed miRNAs targeting some very important gene networks and differentially expressed miRNAs may interfere with butyrate induced modulation of gene expression and cellular functions. The data indicates the complicated interaction between miRNA and histone acetylation forms a highly integrated regulatory mechanism.

scholarly journals Characterization of the delta12‐Prostaglandin J2‐Coenzyme A interaction and its role in epigenetic modulation of gene expression

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Sara Lynn Nicole Farwell ◽  
Vivek Narayan ◽  
Ravindra Kodihalli ◽  
K. Sandeep Prabhu
Keyword(s):  
Gene Expression ◽  
Coenzyme A ◽  
Modulation Of Gene Expression ◽  
Epigenetic Modulation ◽  
Prostaglandin J2
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