scholarly journals Case Series of Morbihan Disease (Extreme Eyelid Oedema Associated with Rosacea): Diagnostic and Therapeutic Approaches

2019 ◽  
Vol 31 (2) ◽  
pp. 196
Author(s):  
Jung Eun Kim ◽  
Chang Yoon Sim ◽  
A Young Park ◽  
Soon Auck Hong ◽  
Young Lip Park ◽  
...  
Keyword(s):  
Case Series ◽  
Therapeutic Approaches ◽  
Eyelid Oedema

scholarly journals Primary Hepatic Angiosarcoma: A Rare Liver Malignancy – Varying Manifestations but Grave Prognosis

2020 ◽  
Vol 14 (1) ◽  
pp. 137-149 ◽  
Author(s):  
Natthapat Rujeerapaiboon ◽  
Panu Wetwittayakhlang
Keyword(s):  
Liver Tumors ◽  
Case Series ◽  
High Rate ◽  
Therapeutic Approaches ◽  
Tumor Rupture ◽  
Liver Malignancies ◽  
Liver Malignancy ◽  
Hepatic Angiosarcoma ◽  
Clinical Presentations ◽  
Primary Hepatic Angiosarcoma

Primary hepatic angiosarcoma (PHA) is a rare mesenchymal liver tumor, accounting for 0.1–2% of primary liver malignancies. The clinical presentations of PHA are variable, from asymptomatic to liver failure or complicated with tumor rupture. The diagnosis of PHA is difficult due to the lack of specific clinical manifestation and investigation results, which can be confused with other liver tumors resulting in late diagnosis. However, there is currently a paucity of effective therapeutic approaches. We advocate early diagnosis with radiological imaging and histopathology because most of them are diagnosed in late-stage and carry a grave prognosis. Surgical resection remains the mainstay of treatment, which can significantly prolong survival. Chemotherapy, including transarterial chemoembolization, is an option for palliative treatment. Unfortunately, molecular treatment has limited efficacy and liver transplantation is also not recommended due to high rate of recurrence. We present a case series of four patients with biopsy-proven PHA which had distinct presentations and clinical courses.

Therapeutic approaches in hypertriglyceridemia‐induced acute pancreatitis: A literature review of available therapies and case series

2019 ◽  
Vol 35 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Abdulaziz Joury ◽  
Mona Alshehri ◽  
Arjun Mahendra ◽  
Mahmoud Anteet ◽  
Mohammad A. Yousef ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Literature Review ◽  
Case Series ◽  
Therapeutic Approaches

scholarly journals Combining therapeutic approaches: rTMS and aerobic exercise in post-stroke depression: a case series

2017 ◽  
Vol 25 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Catherine J. VanDerwerker ◽  
Ryan E. Ross ◽  
Katy H. Stimpson ◽  
Aaron E. Embry ◽  
Stacey E. Aaron ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Case Series ◽  
Therapeutic Approaches ◽  
Post Stroke ◽  
Post Stroke Depression

scholarly journals Disseminated and Relapsing Cryptococcosis: What We Still Have to Learn—a Case Series and Review of Literature

2021 ◽  
Author(s):  
Annarita Botta ◽  
Matteo Piccica ◽  
Filippo Lagi ◽  
Beatrice Borchi ◽  
Lorenzo Zammarchi ◽  
...  
Keyword(s):  
Antifungal Therapy ◽  
Case Reports ◽  
Case Series ◽  
Induction Phase ◽  
Immunosuppressed Patient ◽  
Limited Data ◽  
Therapeutic Approaches ◽  
Risk Factors For Recurrence ◽  
Resistant Strains

AbstractTwo cases of disseminated cryptococcosis are described. The first was an HIV-infected patient where cryptococcosis was diagnosed as “unmasking immune reconstitution syndrome”; the second was an immunosuppressed patient with multiple myeloma. In both cases, a definitive healing could not be reached despite long therapeutic approaches. This review summarizes both the most recent and relevant studies about disseminated and refractory form of cryptococcal infections and identifies research gaps. Given the limited data, we draw some conclusions with respect to management from literature: not clear and accepted indication are available regarding disseminated cryptococcosis, no specific schemes were identified, and the duration of therapy is usually decided case by case and supported only by case reports. In this perspective, usually standard therapeutic schemes and duration of induction depend on multiple factors (e.g., neurologic deficit, non-HIV/non transplant status, CSF culture positivity at 2 weeks, etc.). We found that there are no empiric and literature data that support a role of cryptococcal serum antigen (CRAG) in guiding the antifungal therapy; with the data collected, we think that although is possible, it is very rare to find disseminated cryptococcosis with negative CRAG. We looked also for the more important risk factor of recurrence. Some possible causes explored are risk of azole resistant strains, pre-existent conditions of patients that play a permissive role and the common situation where flucytosine is unavailable that led to suboptimal induction phase of therapy. Herein, we discuss disseminated cryptococcosis with a particular attention to antifungal therapy, role of cryptococcal antigen, and risk factors for recurrence of disease.

scholarly journals Fetoscopic Laser Coagulation in Twin-Twin Transfusion Syndrome: Case Series

2018 ◽  
Vol 24 (1) ◽  
pp. 52
Author(s):  
Aykan Yucel ◽  
Dilek Uygur
Keyword(s):  
Randomized Clinical Trials ◽  
Survival Rates ◽  
Case Series ◽  
Practice Research ◽  
Laser Coagulation ◽  
Perinatal Morbidity ◽  
Health Practice ◽  
Therapeutic Approaches ◽  
Fatal Complication ◽  
Fetoscopic Laser Coagulation

<p>Twin-to-twin transfusion syndrome is a fatal complication and twins with monochorionic/diamniotic placentas are affected due to placental vascular anastomoses, producing volume transfer of blood from one twin to the other. The donor twin becomes hypovolemic with oligohydramnios and the recipient becomes hypervolemic with polyhydramnios. Twin-to-twin transfusion syndrome is associated with increased perinatal morbidity and mortality and expresses longstanding health hazards. Serial amnioreduction and fetoscopic laser photocoagulation of the vascular anastomoses are the main therapeutic approaches for twin-to-twin transfusion syndrome. Higher survival rates after fetoscopic laser ablation of the anastomotic vessels in comparison to serial amnioreduction have been reported in multicenter randomized clinical trials. We report the fetoscopic laser coagulation of three twin-to-twin transfusion syndrome cases at Ankara Dr. Zekai Tahir Burak Health Practice Research Center, Perinatology Clinics. </p>

scholarly journals Late-Developing Supernumerary Premolars: Analysis of Different Therapeutic Approaches

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Sergio Paduano ◽  
Roberto Rongo ◽  
Alessandra Lucchese ◽  
Domenico Aiello ◽  
Ambrosina Michelotti ◽  
...  
Keyword(s):  
Treatment Plan ◽  
Case Series ◽  
Permanent Dentition ◽  
Therapeutic Approaches ◽  
Supernumerary Teeth ◽  
Lower Jaw

This case series describes the different potential approaches to late-developing supernumerary premolars (LDSP). LDSP are supernumerary teeth (ST) formed after the eruption of the permanent dentition; usually they develop in the premolar region of the upper and lower jaw. The choice to extract or to monitor the LDSP depends on many factors and has to be carefully planned due to the several risks that either the monitoring or the extraction could provoke. These four cases of LDSP showed different treatment plan alternatives derived from a scrupulous assessment of the clinical and radiographic information.

scholarly journals Targeted therapeutic approaches in squamous cell vulvar cancer (VSCC): Case series and review of the literature

2020 ◽  
Author(s):  
Linn Woelber ◽  
Sabrina Mathey ◽  
Katharina Prieske ◽  
Sascha Kuerti ◽  
Christoph Hillen ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Vulvar Cancer ◽  
Gynecological Cancer ◽  
Case Series ◽  
Cancer Center ◽  
Therapeutic Approaches ◽  
Duration Of Treatment ◽  
Best Response ◽  
Platinum Based Chemotherapy ◽  
Targeted Therapeutic

Therapeutic options in recurrent or metastasized VSCC not amenable to radiotherapy or radical surgery are limited. Evidence for the use of targeted therapies is sparse. All patients with VSCC treated at the Gynecological Cancer Center Hamburg-Eppendorf 2013 - 2019 were retrospectively evaluated for targeted therapeutic approaches. Furthermore, a MEDLINE, EMBASE-, Web of Science-, Scopus- and OVID database search was performed using the terms: ‘vulvar cancer’ AND ‘targeted therapy’, ‘erlotinib’, ‘EGFR’, ‘bevacizumab’, ‘VEGF’, ‘pembrolizumab or ‘immunotherapy’. 12/291 patients (4.1%) with VSCC received at least one targeted therapy at our institution. Previously, one or more platinum-based chemotherapy was applied to all patients (median 3.5 previous lines (range 2-5). In the erlotinib subgroup 2/5 patients (40%) achieved stable disease (SD) while two patients (2/5, 40%) experienced partial response (PR). Treatment was given as monotherapy in 2nd/3rd line for a median of 3.4 months (range 2-6 months). Bevacizumab (n=9) was given as maintenance therapy after platinum-based first-line chemotherapy (9/9), best response was complete response (CR) (n=2/9 22.2%). Median duration of treatment was 7 months (range 4-13 months) with two patients still under ongoing treatment. Best response in the pembrolizumab (n=3) subset was SD (n=1/3 33%). Treatment was given as monotherapy in 2nd/3rd line for a median of 3.3 months (range 3-4 months). 9/12 patients (75%) experienced treatment-related AEs (TRAEs), most commonly grade 1/2. Rapidly evolving antibody treatments have proven clinical benefit especially in HPV-driven tumor entities, however, clinical investigations in VSCC are still limited. These reported cases provide evidence for the clinical utility and feasibility while ensuring an acceptable safety profile.

scholarly journals Ectopic Cervical Pregnancy: Treatment Route

Medicina ◽  
2020 ◽  
Vol 56 (6) ◽  
pp. 293 ◽  
Author(s):  
Guglielmo Stabile ◽  
Francesco Paolo Mangino ◽  
Federico Romano ◽  
Giulia Zinicola ◽  
Giuseppe Ricci
Keyword(s):  
Vaginal Bleeding ◽  
Case Series ◽  
Therapeutic Approaches ◽  
Cervical Pregnancy ◽  
Spontaneous Pregnancy ◽  
Future Fertility ◽  
Therapeutic Protocols ◽  
Β Hcg ◽  
Endocervical Canal ◽  
Surgical Treatments

Background and objectives: Cervical pregnancy (CP) is a rare form of ectopic pregnancy (EP) in which the embryo implants and grows inside the endocervical canal. Early diagnosis is essential in order to allow conservative medical and surgical treatments. Although many treatment approaches are disponible, the most effective is still unclear. The aim of this study is to evaluate the efficacy of hysteroscopic management in early CP in order to preserve future fertility. Materials and Methods: This is a retrospective observational case series. Five patients with a diagnosis of CP, hemodynamically stables and managed conservatively between 2014 and 2019 at the Institute of Child and Maternal Health Burlo Garofolo in Trieste, Italy, were included. Four patients, with βhCG levels > 5000 mUi/mL were managed by hysteroscopy, with or without a previous systemic Methotrexate (MTX). One case with βhCG levels < 5000 mUi/mL was treated using MTX combined to Mifepristone and Misoprostol. Results: In one patient treated by hysteroscopy alone it occurred a profuse vaginal bleeding with necessity for blood transfusion. Haemorrhage was controlled by a second hysteroscopic procedure. No complications, such as vaginal bleeding, were recorded in the other cases. Serum β-hCG levels become undetectable in a range of 15–40 days after hysteroscopic management; after medical treatment it become undetectable after 35 days. Serum βhCG levels had a faster drop the day after hysteroscopy than post medical management. The onset of a spontaneous pregnancy at the normal implantation site occurred after five months in one case treated by hysteroscopy. Conclusions: Many therapeutic approaches are effective for CP treatment. Hysteroscopy, alone or in combination with MTX, may provide a greater effect on the descent of βhCG, leading to a reduction of the hospitalization stay, decreasing costs and period for attempt pregnancy. Further prospective studies on larger samples are needed to define therapeutic protocols for CP management.

Biliary Tract Candidiasis: Diagnostic and Therapeutic Approaches in a Case Series

2006 ◽  
Vol 101 (11) ◽  
pp. 2530-2536 ◽  
Author(s):  
Dirk Domagk ◽  
Wolfgang Fegeler ◽  
Beate Conrad ◽  
Josef Menzel ◽  
Wolfram Domschke ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Case Series ◽  
Therapeutic Approaches
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