T-and cross-reactive B-cell epitopes of Porphyromonas gingivalis and human heat shock protein 60 in atherosclerosis

2003 ◽  
Vol 33 (3) ◽  
pp. 331
Author(s):  
Jeom-Il Choi
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
B Cell ◽  
Porphyromonas Gingivalis ◽  
Heat Shock Protein 60 ◽  
B Cell Epitopes ◽  
Human Heat Shock Protein

scholarly journals Cross-Reactive B-Cell Epitopes of Microbial and Human Heat Shock Protein 60/65 in Atherosclerosis

2003 ◽  
Vol 23 (6) ◽  
pp. 1060-1065 ◽  
Author(s):  
Hannes Perschinka ◽  
Manuel Mayr ◽  
Gunda Millonig ◽  
Christina Mayerl ◽  
Ruurd van der Zee ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
B Cell ◽  
Heat Shock Protein 60 ◽  
B Cell Epitopes ◽  
Human Heat Shock Protein

Epitope Mapping of Porphyromonas gingivalis Heat-shock Protein and Human Heat-shock Protein in Human Atherosclerosis

2004 ◽  
Vol 83 (12) ◽  
pp. 936-940 ◽  
Author(s):  
J.-I. Choi ◽  
S.-W. Chung ◽  
H.-S. Kang ◽  
B.Y. Rhim ◽  
Y.-M. Park ◽  
...  
Keyword(s):  
T Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
B Cell ◽  
Cell Epitope ◽  
T Cell Epitopes ◽  
Igg Antibody ◽  
B Cell Epitopes ◽  
Human Heat Shock Protein ◽  
Human Hsp60

To identify T- and/or cross-reactive B-cell epitopes of P. gingivalis and human heat-shock protein (HSP)60 in atherosclerosis patients, we synthesized 104 overlapping synthetic peptides spanning whole molecules of P. gingivalis HSP60 and human HSP60, respectively. T-cell epitopes of P. gingivalis HSP were identified with the use of previously established P. gingivalis HSP-reactive T-cell lines. B-cell epitopes of P. gingivalis HSP60 and human HSP60 were identified by the use of patients’ sera. Anti- P. gingivalis, anti- P. gingivalis HSP60, or anti-human HSP60 IgG antibody titers were higher in the atherosclerosis patients compared with the healthy subjects. Five immunodominant peptides of P. gingivalis HSP60, identified as T-cell epitopes, were also found to be B-cell epitopes. Moreover, 6 cross-reactive B-cell epitopes of human HSP60 were identified. It was concluded that P. gingivalis HSP60 might be involved in the immunoregulatory process of atherosclerosis, with common T- and/or B-cell epitope specificities and with cross-reactivity with human HSP60.

scholarly journals Circulating Human Heat Shock Protein 60 in the Plasma of British Civil Servants

Circulation ◽  
2002 ◽  
Vol 106 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Jo Lewthwaite ◽  
Natalie Owen ◽  
Anthony Coates ◽  
Brian Henderson ◽  
Andrew Steptoe
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Civil Servants ◽  
Heat Shock Protein 60 ◽  
Human Heat Shock Protein

scholarly journals Independent and Joint Effects of Antibodies to Human Heat-Shock Protein 60 andChlamydia pneumoniaeInfection in the Development of Coronary Atherosclerosis

Circulation ◽  
2001 ◽  
Vol 103 (11) ◽  
pp. 1503-1508 ◽  
Author(s):  
Katalin Burian ◽  
Zoltan Kis ◽  
Dezso Virok ◽  
Valeria Endresz ◽  
Zoltan Prohaszka ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Coronary Atherosclerosis ◽  
Heat Shock Protein 60 ◽  
Joint Effects ◽  
Human Heat Shock Protein

scholarly journals Inhibition of Adjuvant Arthritis by a DNA Vaccine Encoding Human Heat Shock Protein 60

2002 ◽  
Vol 169 (6) ◽  
pp. 3422-3428 ◽  
Author(s):  
Francisco J. Quintana ◽  
Pnina Carmi ◽  
Felix Mor ◽  
Irun R. Cohen
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Dna Vaccine ◽  
Adjuvant Arthritis ◽  
Heat Shock Protein 60 ◽  
Human Heat Shock Protein

OR.42. Human Heat Shock Protein 60 Induces Differentiation of Cd4+Cd3//Q T-Cells Into Foxp3+Cd4+Cd25//0 Regulatory T-Cells

2006 ◽  
Vol 119 ◽  
pp. S19-S20
Author(s):  
Yvonne Vercoulen ◽  
Isme De Kleer ◽  
Sylvia Kamphuis ◽  
Huib de Jong ◽  
Mark Klein ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Regulatory T Cells ◽  
Heat Shock Protein ◽  
Heat Shock Protein 60 ◽  
Human Heat Shock Protein
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