Chemistry for Nucleic Acid Analogs Having Sulfur and Selenium Atoms in Place of Furanose Ring Oxygen

2020 ◽  
Vol 78 (5) ◽  
pp. 446-455
Author(s):  
Masashi Ota ◽  
Noriko Saito-Tarashima ◽  
Noriaki Minakawa
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Analogs

Synthesis and Interaction of Water Soluble Nucleic Acid Analogs

1991 ◽  
pp. 31-45 ◽  
Author(s):  
Kiichi Takemoto ◽  
Takehiko Wada ◽  
Eiko Mochizuki ◽  
Yoshiaki Inaki
Keyword(s):  
Nucleic Acid ◽  
Water Soluble ◽  
Nucleic Acid Analogs

Nucleic Acid Analogs: Their Specific Interaction and Applicability

1990 ◽  
pp. 253-267 ◽  
Author(s):  
Kiichi Takemoto ◽  
Eiko Mochizuki ◽  
Takehiko Wada ◽  
Yoshiaki Inaki
Keyword(s):  
Nucleic Acid ◽  
Specific Interaction ◽  
Nucleic Acid Analogs

scholarly journals Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2866 ◽  
Author(s):  
Aniket Wahane ◽  
Akaash Waghmode ◽  
Alexander Kapphahn ◽  
Karishma Dhuri ◽  
Anisha Gupta ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nucleic Acid ◽  
Messenger Rna ◽  
Viral Vectors ◽  
Cationic Lipids ◽  
Nucleic Acid Delivery ◽  
Nucleic Acid Analogs ◽  
Organ Specific ◽  
Interfering Rna

The field of gene therapy has experienced an insurgence of attention for its widespread ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA, and short-interfering RNA for treating malignant and non-malignant disorders. Numerous nucleic acid analogs have been developed to target coding or non-coding sequences of the human genome for gene regulation. However, broader clinical applications of nucleic acid analogs have been limited due to their poor cell or organ-specific delivery. To resolve these issues, non-viral vectors based on nanoparticles, liposomes, and polyplexes have been developed to date. This review is centered on non-viral vectors mainly comprising of cationic lipids and polymers for nucleic acid-based delivery for numerous gene therapy-based applications.

scholarly journals Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Shu-ichi Nakano ◽  
Masayuki Fujii ◽  
Naoki Sugimoto
Keyword(s):  
Nucleic Acid ◽  
Base Pair ◽  
Double Helix ◽  
Nucleoside Analogs ◽  
Structural Analog ◽  
Base Pairs ◽  
Nucleic Acid Analogs ◽  
Dna Double Helix ◽  
Nucleic Acid Interactions ◽  
Site Selective

Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides. This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of nucleic acid interactions. We also describe the nucleoside analogs of a base pair-mimic structure that we have examined. Although the base pair-mimic nucleosides possess a simplified stacking moiety of a phenyl or naphthyl group, they can be used as a structural analog of Watson-Crick base pairs. Remarkably, they can adopt two different conformations responding to their interaction energies, and one of them is the stacking conformation of the nonpolar aromatic group causing the site-selective flipping of the opposite base in a DNA double helix. The base pair-mimic nucleosides can be used to study the mechanism responsible for the base stacking and the flipping of bases out of a nucleic acid duplex.

BNAs: novel nucleic acid analogs with a bridged sugar moiety

2002 ◽  
pp. 1653-1659 ◽  
Author(s):  
Takeshi Imanishi ◽  
Satoshi Obika
Keyword(s):  
Nucleic Acid ◽  
Sugar Moiety ◽  
Nucleic Acid Analogs

Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9

Immunobiology ◽  
2008 ◽  
Vol 213 (3-4) ◽  
pp. 315-328 ◽  
Author(s):  
Stefan Bauer ◽  
Stephanie Pigisch ◽  
Doris Hangel ◽  
Andreas Kaufmann ◽  
Svetlana Hamm
Keyword(s):  
Nucleic Acid ◽  
Toll Like Receptors ◽  
Nucleic Acid Analogs

Synthesis of Amino-Acid-Derived Nucleo(side/tide) Analogs for Peptide-Derived Enantiospecific Nucleic Acid Analogs

1996 ◽  
Vol 24 (2) ◽  
pp. 194-200 ◽  
Author(s):  
Vibhakar J. Shah ◽  
Irwin D. Kuntz, Jr. ◽  
George L. Kenyon
Keyword(s):  
Amino Acid ◽  
Nucleic Acid ◽  
Nucleic Acid Analogs
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