scholarly journals The relationship of angiogenesis with prognostic factors in non-small cell lung cancers

2018 ◽  
Vol 2 (1) ◽  
pp. 10
Author(s):  
Sevilay ÖZMEN ◽  
Cemal GÜNDOĞDU
2020 ◽  
Vol 31 (3) ◽  
pp. 305-314
Author(s):  
Tomohiro Maniwa ◽  
Akiisa Ohmura ◽  
Takashi Hiroshima ◽  
Akihiro Ike ◽  
Toru Kimura ◽  
...  

Abstract OBJECTIVES Characterizing pathological nodes (pNs) by location alone is sometimes inadequate as patients with pN1 or pN2 non-small-cell lung cancer (NSCLC) show prognostic heterogeneity. We aimed to assess the relationship of the number of metastatic lymph nodes (LNs) and zones with prognosis in NSCLC patients. METHODS We analysed 1393 patients who underwent lobectomy with mediastinal LN dissection for NSCLC at the Osaka International Cancer Institute between January 2006 and December 2015. Patients were classified into 3 groups according to the number of LNs: n1–3, n4–6 and n7–. We investigated the relationship of prognosis with the number of metastatic LNs and metastatic zones. RESULTS In the multivariable analyses, the number of metastatic LNs and zones were not independent factors for overall survival or recurrence-free survival in patients with pN1 disease after adjustment for age, sex, tumour histology and tumour diameter. However, n4–6 (ref. n1–3) was an independent prognostic factor for overall survival [hazard ratio (HR) 4.148, P < 0.001] in those with pN2 disease. There were no significant differences in overall survival and recurrence-free survival between pN1 (HR 0.674, P = 0.175) and pN2n1–3 disease (HR 1.056, P = 0.808). Moreover, patients with pN2 disease with a higher number of metastatic zones had a poor prognosis for recurrence-free survival [3 zones (ref. 1): HR 1.774, P = 0.051, and 4 zones (ref. 1): HR 2.173, P < 0.047]. CONCLUSIONS The number of metastatic LNs and metastatic zones were useful prognostic factors in NSCLC patients. The findings could help in establishing a new pN classification.


2012 ◽  
Vol 7 (7) ◽  
pp. 1124-1130 ◽  
Author(s):  
Francesca Toffalorio ◽  
Davide Radice ◽  
Lorenzo Spaggiari ◽  
Valentina Sinno ◽  
Massimo Barberis ◽  
...  

2004 ◽  
Vol 91 (4) ◽  
pp. 771-774 ◽  
Author(s):  
S Toyooka ◽  
M Suzuki ◽  
R Maruyama ◽  
K O Toyooka ◽  
K Tsukuda ◽  
...  

2004 ◽  
Author(s):  
Tetsuro Hanabata ◽  
Kazunori Tsukuda ◽  
Shinichi Toyooka ◽  
Masaaki Yano ◽  
Motoi Aoe ◽  
...  

Lung Cancer ◽  
2005 ◽  
Vol 49 (3) ◽  
pp. 371-376 ◽  
Author(s):  
R. Berardi ◽  
A. Brunelli ◽  
T. Tamburrano ◽  
L. Verdecchia ◽  
A. Onofri ◽  
...  

2015 ◽  
Vol 3 (S2) ◽  
Author(s):  
Hidenori Takahashi ◽  
Shigetaka Shimodaira ◽  
Masahiro Ogasawara ◽  
Masanori Kobayashi ◽  
Hirofumi Abe ◽  
...  

2012 ◽  
Vol 13 (2) ◽  
pp. 60-64
Author(s):  
Bala Basak Oven Ustaalioglu ◽  
Ahmet Bilici ◽  
Mesut Seker ◽  
Taflan Salepci ◽  
Recep Ustaalioglu ◽  
...  

Medicine ◽  
2019 ◽  
Vol 98 (32) ◽  
pp. e16764 ◽  
Author(s):  
Nan-Nan Bian ◽  
Xin-Yu Shi ◽  
Hong-Yu Qi ◽  
Xin Hu ◽  
Yang Ge ◽  
...  

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