scholarly journals Assisting in vitro fertilization by manipulating cumulus-oocyte-complexes either mechanically or enzymatically does not prevent IVF failure

2011 ◽  
Vol 12 (3) ◽  
pp. 135-139 ◽  
Author(s):  
Thomas Ebner ◽  
Marianne Moser ◽  
Omar Shebl ◽  
Richard Mayer ◽  
Gernot Tews
2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092602 ◽  
Author(s):  
Danni Qu ◽  
Yuan Li

Objective To evaluate the efficacy and safety of multiple- versus single-dose gonadotropin-releasing hormone agonist (GnRH-a) addition to luteal phase support (LPS), in patients with a first in vitro fertilization (IVF) failure associated with luteal phase deficiency (LPD). Methods Eighty patients with a first IVF failure associated with LPD were randomly assigned into single-dose and multiple-dose GnRH-a groups. In the second IVF attempt, patients in the single-dose group were given standard LPS plus a single dose of GnRH-a 6 days after oocyte retrieval. Patients in the multiple-dose group received standard LPS plus 14 daily injections of GnRH-a. Children conceived were followed up for 2 years. Results Pregnancy (67.5% vs. 42.5%), clinical pregnancy (50.0% vs. 22.5%), and live birth rates (42.5% vs. 20.0%) were significantly higher in the multiple-dose versus single-dose GnRH-a group. Patients in the multiple-dose GnRH-a group had significantly higher progesterone levels 14 days after oocyte recovery (35.9 vs. 21.4 ng/mL). No significant difference existed in the status at birth or developmental and behavior assessments of 2-year-old children conceived in both groups. Conclusions Daily addition of GnRH-a to standard LPS can achieve better pregnancy outcomes with a sustained safety profile in patients with a first IVF failure associated with LPD.


2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Hend Allaw ◽  
Almoutassem Billah Zetoune ◽  
Marwan Alhalabi

Endometriosis is a very common debilitating disease that occurs in 6 to 10 percent of the general female population; in women with pain, infertility, or both, the frequency is 35–50%. Endometriosis is one of the most important causes of infertility. Our objective is to evaluate the effect of endometriosis and adenomyosis on IVF outcome (ongoing pregnancy). 65 women underwent In Vitro Fertilization (IVF) and embryos transfer who had endometriosis with or without adenomyosis were recruited in this retrospective study, resulting in 53.8% had a successful IVF attempt (get pregnant). The highest success rate of IVF was in women who were in mild of endometriosis and IVF failure rate was increased mainly in women who were in severe endometriosis. So, the presence of adenomyosis affects IVF outcome and decreases the rate of implantation.


2020 ◽  
Vol 203 ◽  
pp. e538
Author(s):  
M. Blake Evans ◽  
Jessica Marinaro* ◽  
Allison Eubanks ◽  
Kate Devine ◽  
Micah Hill ◽  
...  

2009 ◽  
Vol 24 (10) ◽  
pp. 2541-2548 ◽  
Author(s):  
M. Koler ◽  
H. Achache ◽  
A. Tsafrir ◽  
Y. Smith ◽  
A. Revel ◽  
...  

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