Are Pattern Recognition Receptors Associated with Hepatocellular Carcinoma?

2021 ◽  
Vol 32 (7) ◽  
pp. 593-599
Author(s):  
Ramazan Dertli ◽  
◽  
Mehmet Asil ◽  
Murat Biyik ◽  
Ahmet Karakarcayildiz ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pattern Recognition ◽  
Pattern Recognition Receptors

scholarly journals Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors

Platelets ◽  
2021 ◽  
pp. 1-13
Author(s):  
Samantha J. Montague ◽  
Pushpa Patel ◽  
Eleyna M. Martin ◽  
Alexandre Slater ◽  
Lourdes Garcia Quintanilla ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Platelet Activation ◽  
Pattern Recognition Receptors ◽  
Platelet Glycoprotein ◽  
Charged Ligands

scholarly journals Pattern recognition receptors: A contemporary view on liver diseases

Hepatology ◽  
2006 ◽  
Vol 44 (2) ◽  
pp. 287-298 ◽  
Author(s):  
Gyongyi Szabo ◽  
Angela Dolganiuc ◽  
Pranoti Mandrekar
Keyword(s):  
Pattern Recognition ◽  
Liver Diseases ◽  
Pattern Recognition Receptors ◽  
Contemporary View

scholarly journals Gene Expression of Nucleic Acid-Sensing Pattern Recognition Receptors in Children Hospitalized for Respiratory Syncytial Virus-Associated Acute Bronchiolitis

2009 ◽  
Vol 16 (6) ◽  
pp. 816-823 ◽  
Author(s):  
Carolina Scagnolari ◽  
Fabio Midulla ◽  
Alessandra Pierangeli ◽  
Corrado Moretti ◽  
Enea Bonci ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pattern Recognition ◽  
Viral Load ◽  
Respiratory Syncytial Virus ◽  
Pattern Recognition Receptors ◽  
Mrna Levels ◽  
Acute Bronchiolitis ◽  
Expression Levels ◽  
Rsv Infection ◽  
Syncytial Virus

ABSTRACT Given the critical role of pattern recognition receptors (PRRs) in acid nucleic recognition in the initiation of innate immunity and the orchestration of adaptive immunity, the aim of this study was to determine whether any heterogeneity of PRR expression in the airway tracts of infants with respiratory syncytial virus (RSV) infection might explain the broad clinical spectrum of RSV-associated bronchiolitis in infants. For this purpose, the levels of melanoma differentiation-associated protein-5 (MDA-5), retinoic acid inducible gene-1 (RIG-1), and Toll-like receptor 3 (TLR-3), TLR-7, TLR-8, and TLR-9 mRNAs were evaluated, using TaqMan quantitative reverse transcription-PCR, in cells from nasopharyngeal washes collected from 157 infants suffering from acute bronchiolitis whether or not they were associated with respiratory viruses. High interindividual variability was observed in both virus-positive and -negative infants; however, the relative gene expression levels of MDA-5, RIG-1, TLR-7, and TLR-8 were significantly higher in the virus-infected group, whereas the expression levels of TLR-3 and TLR-9 were not significantly different. The differences in the gene expression of MDA-5, RIG-1, TLR-7, and TLR-8 were more evident in infants with RSV infection than in those with bocavirus or rhinovirus infection. In RSV-infected infants, PRR-mRNA levels also were analyzed in relation to interferon protein levels, viral load, clinical severity, days of hospitalization, age, and body weight. A significant positive correlation was observed only between RSV viral load and RIG-1 mRNA levels. These findings provide the first direct evidence that, in infants with respiratory virus-associated bronchiolitis, especially RSV, there are substantial changes in PRR gene expression; this likely is an important determinant of the clinical outcome of bronchiolitis.

scholarly journals Genetic Variation in Pattern Recognition Receptors and Adaptor Proteins Associated With Development of Chronic Q Fever

2015 ◽  
Vol 212 (5) ◽  
pp. 818-829 ◽  
Author(s):  
Teske Schoffelen ◽  
Anne Ammerdorffer ◽  
Julia C. J. P. Hagenaars ◽  
Chantal P. Bleeker-Rovers ◽  
Marjolijn C. Wegdam-Blans ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Genetic Variation ◽  
Q Fever ◽  
Adaptor Proteins ◽  
Pattern Recognition Receptors ◽  
Chronic Q Fever
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