scholarly journals DIABETIC ENTEROPATHY

2018 ◽  
pp. 70-74
Author(s):  
O. A. Yarmolenko ◽  
E. G. Malayeva ◽  
I. A. Khudyakov ◽  
M. N. Menshakova ◽  
L. A. Kobruseva
Keyword(s):  
Diabetes Mellitus ◽  
Small Intestine ◽  
Young Patient ◽  
Bacterial Growth ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Diabetes Mellitus Type 1 ◽  
Peristaltic Activity ◽  
Diabetic Enteropathy

Diabetic enteropathy is a rarely diagnosed complication of diabetes mellitus. According to literature sources, most researchers note an association of this complication with the manifestation of diabetic autonomic neuropathy. The main clinical manifestations of diabetic enteropathy are: disrupted peristaltic activity of the small intestine, excessive bacterial growth, diarrhea, and steatorrhea. The article describes a clinical case of diabetic enteropathy in a young patient, which developed 8 years after diabetes mellitus type 1 had been diagnosed.

scholarly journals Diabetes and family hypercholesterolemia in a child: is it real?

2019 ◽  
Vol 64 (4) ◽  
pp. 88-91
Author(s):  
L. F. Galimova ◽  
D. I. Sadykova ◽  
I. V. Leontyeva ◽  
E. S. Slastnikova ◽  
M. R. Shaidullina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Familial Hypercholesterolemia ◽  
Clinical Case ◽  
Receptor Gene ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Target Tissue

Diabetes mellitus type 1 is one of the most common chronic diseases among children. It is a pathology of carbohydrate, fat and protein metabolism caused by insulin deficiency in the target tissue. Changes in the lipid profile can be both secondary and primary. The article describes a clinical case of a combination of diabetes mellitus type 1 and family hypercholesterolemia in a child. It presents the clinical and laboratory results of the examination of the child and his parents. Familial hypercholesterolemia is confirmed by mutation of the low density lipoprotein receptor gene (LDLR) in the heterozygous state. In addition, the proband has a polymorphism of the SLCO1B1 gene, which should be considered when prescribing therapy. The demonstrated clinical case shows that familial hypercholesterolemia can be an independent disease, aggravating the course of diabetes mellitus and requiring correction of the therapy.

scholarly journals Features of the manifestation of type 1 diabetes in children and teenagers in the Perm Region

2020 ◽  
Vol 10 (5) ◽  
pp. 51-56
Author(s):  
Olga M. Khudorozhkova ◽  
Elena N. Smirnova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Clinical Manifestations ◽  
Diabetes Mellitus Type 1 ◽  
Adverse Outcomes ◽  
Diabetes Mellitus Type ◽  
Significant Difference ◽  
Diagnosed Diabetes ◽  
Perm Region

Clinical manifestations of type 1 diabetes mellitus (type 1 diabetes) in children largely depend on the age of the child and the degree of decompensation of metabolic processes at the time of its diagnosis. Early detection of diabetes and early treatment can improve the prognosis of the disease and reduce the risk of further complications and adverse outcomes. The purposeof this work: to identify the features of the manifestation of type 1 diabetes in children in the Perm Region, who fell ill from 2002 to 2017. Methods.The data of anamnesis, clinical and instrumental methods of research were analyzed in 378 patients with newly diagnosed diabetes mellitus type 1 in the period of hospitalization from 2002 to 2017 (378 people). Results.It is revealed that boys and girls get diabetes with the same frequency. The incidence of disease in recent years among rural residents remains at a lower level than in the cities of the region. There is a high incidence of disease throughout the year, regardless of the season. Initiating factors are infectious diseases, as well as various stressful situations. A standard examination in patients revealed changes corresponding to the state of hyperglycemia. One third of patients had ketoacidosis of varying severity. In11% of children, diabetes mellitus was suspected during routine follow-up. Among the comorbidities most frequently encountered are problems of the nervous system and other endocrine diseases. Almost a quarter of patients had burdened heredity according to type 1 diabetes. When comparing the data of anamnesis and manifestation of type 1 diabetes with the data of other regions, no significant difference was found.

Psychological problems in children with diabetes mellitus type 1

2015 ◽  
Author(s):  
Anzhalika Solntsava ◽  
Olga Zagrebaeva ◽  
Nadeya Peskavaya ◽  
Viktoryia Kozel ◽  
Hanna Mikhno
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Psychological Problems ◽  
Diabetes Mellitus Type

Seksuele problemen bij vrouwen met diabetes mellitus type 1 en bij een vergelijkbare controlegroep

2002 ◽  
Vol 58 (23) ◽  
pp. 1589-1598
Author(s):  
ENZLIN P ◽  
MATHIEU C ◽  
VAN DEN BRUEL A ◽  
BOSTEELS J ◽  
VANDERSCHUEREN D ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type

Monogenic Diabetes: Genetics and Relevance on Diabetes Mellitus Personalized Medicine

2020 ◽  
Vol 16 (8) ◽  
pp. 807-819 ◽  
Author(s):  
Madalena Sousa ◽  
Jácome Bruges-Armas
Keyword(s):  
Diabetes Mellitus ◽  
Complex Disease ◽  
Clinical Manifestations ◽  
Neonatal Diabetes ◽  
Monogenic Diabetes ◽  
Diabetes Genetics ◽  
Individualize Treatment

Background: Diabetes mellitus (DM) is a complex disease with significant impression in today's world. Aside from the most common types recognized over the years, such as type 1 diabetes (T1DM) and type 2 diabetes (T2DM), recent studies have emphasized the crucial role of genetics in DM, allowing the distinction of monogenic diabetes. Methods: Authors did a literature search with the purpose of highlighting and clarifying the subtypes of monogenic diabetes, as well as the accredited genetic entities responsible for such phenotypes. Results: The following subtypes were included in this literature review: maturity-onset diabetes of the young (MODY), neonatal diabetes mellitus (NDM) and maternally inherited diabetes and deafness (MIDD). So far, 14 subtypes of MODY have been identified, while three subtypes have been identified in NDM - transient, permanent, and syndromic. Discussion: Despite being estimated to affect approximately 2% of all the T2DM patients in Europe, the exact prevalence of MODY is still unknown, accentuating the need for research focused on biomarkers. Consequently, due to its impact in the course of treatment, follow-up of associated complications, and genetic implications for siblings and offspring of affected individuals, it is imperative to diagnose the monogenic forms of DM accurately. Conclusion: Currently, advances in the genetics field allowed the recognition of new DM subtypes, which until now, were considered slight variations of the typical forms. Thus, it is imperative to act in the close interaction between genetics and clinical manifestations, to facilitate diagnosis and individualize treatment.

Evolution of Hashimoto thyroiditis in children with type 1 diabetes mellitus (TIDM)

2020 ◽  
Vol 33 (12) ◽  
pp. 1525-1531
Author(s):  
Feneli Karachaliou ◽  
Nikitas Skarakis ◽  
Evangelia Bountouvi ◽  
Theodora Spyropoulou ◽  
Eleni Tsintzou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Randomized Trials ◽  
Elevated Serum ◽  
Hashimoto Thyroiditis ◽  
Diabetes Mellitus Type 1 ◽  
Overt Hypothyroidism ◽  
Normal Ranges ◽  
Serum Tsh

AbstractObjectivesTreatment of children with Hashimoto thyroiditis (HT) and particularly of those with coexistent diabetes mellitus type 1 (TIDM) and normal/mildly elevated serum TSH is controversial. The aim of the study was to evaluate the natural course of HT in children with TIDM compared with children with no other coexistent autoimmunity and investigate for possible predictive factors of thyroid function deterioration.MethodsData from 96 children with HT, 32 with T1DM (23 girls, nine boys) mean (sd) age: 10.6 (2.3) years, and 64 age and sex-matched without T1DΜ (46 girls, 18 boys), mean (sd) age: 10.2 (2.9) years were evaluated retrospectively. They all had fT4 and TSH values within normal ranges and available data for at least three years’ follow-up.ResultsDuring the follow-up period, 11 children (34.4%) with TIDM exhibited subclinical hypothyroidism and two children (6.2%) progressed to overt hypothyroidism compared to 12 (18.8%) and two (3.1%) among children without TIDM, respectively. Among children with HT, a higher percentage (40.6%) of children with T1DM progressed to subclinical or overt hypothyroidism, compared with children (21.9%) with similar characteristics but without TIDM or other coexistent autoimmunity.ConclusionsThe annual conversion rate from euthyroidism to hypothyroidism in children with T1DM was significantly higher compared to sex and age-matched children without TIDM. Prospective randomized trials are needed to support the view of an earlier intervention therapy even in milder degrees of thyroid failure in these children.

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