scholarly journals Zoonotic origins of Coronavirus (Covid-19) in light of SARS-CoV and MERS-CoV

Author(s):  
Siham Soulaimi ◽  
Mohamed LAHKIM ◽  
Ahmed BELMOUDEN ◽  
Abdellah HOUARI ◽  
Abderrahim ANBI ◽  
...  
Keyword(s):  

Cases of unknown pneumonia were increasingly reported in China in late 2019, causing a serious start to 2020 with a pandemic called Covid-19 which has negatively affected humans and claimed the lives of people of all ages, especially the elderly and those with existing illnesses. Since this is not the first known coronavirus, it is necessary to examine the first ones and their characteristics which have not shown much difference with the current Covid-19 in terms of the main symptoms and modes of transmission.Scientists and researchers are trying to unravel the origin story, regarding the species that passed it on to humans, as knowing how one pandemic emerged is a key point in stopping the next. According to a number of studies and researches, this article suggests that the virus is very likely to originate from bats and infect an intermediate animal (probably pangolins) in the same way that the SARS epidemic was transmitted from bats to civets before it infect humans, and that of MERS in which the virus wasoriginally passed from bats to camels and then to humans..However, it is important to note that not all bat species are suspected, and studies point out that animals are likely to harbor a virus and transmit it to a human who can also infect their species via the route. transmission.

Author(s):  
J. Jacob ◽  
M.F.M. Ismail

Ultrastructural changes have been shown to occur in the urinary bladder epithelium (urothelium) during the life span of humans. With increasing age, the luminal surface becomes more flexible and develops simple microvilli-like processes. Furthermore, the specialised asymmetric structure of the luminal plasma membrane is relatively more prominent in the young than in the elderly. The nature of the changes at the luminal surface is now explored by lectin-mediated adsorption visualised by scanning electron microscopy (SEM).Samples of young adult (21-31 y old) and elderly (58-82 y old) urothelia were fixed in buffered 2% glutaraldehyde for 10 m and washed with phosphate buffered saline (PBS) containing Ca++ and Mg++ at room temperature. They were incubated overnight at 4°C in 0.1 M ammonium chloride in PBS to block any remaining aldehyde groups. The samples were then allowed to stand in PBS at 37°C for 2 h before incubation at 37°C for 30 m with lectins. The lectins used were concanavalin A (Con A), wheat germ agglutinin (WGA), phytohaemagglutinin (PHA) and pokeweed mitogen (PWM) at a concentration of 500 mg/ml in PBS at pH 7.A.


1988 ◽  
Vol 52 (9) ◽  
pp. 516-518 ◽  
Author(s):  
J Mann ◽  
TJ Bomberg ◽  
JM Holtzman ◽  
DB Berkey
Keyword(s):  

Author(s):  
Angel L. Ball ◽  
Adina S. Gray

Pharmacological intervention for depressive symptoms in institutionalized elderly is higher than the population average. Among the patients on such medications are those with a puzzling mix of symptoms, diagnosed as “dementia syndrome of depression,” formerly termed “pseudodementia”. Cognitive-communicative changes, potentially due to medications, complicate the diagnosis even further. This discussion paper reviews the history of the terminology of “pseudodementia,” and examines the pharmacology given as treatment for depressive symptoms in the elderly population that can affect cognition and communication. Clinicians can reduce the risk of misdiagnosis or inappropriate treatment by having an awareness of potential side effects, including decreased attention, memory, and reasoning capacities, particularly due to some anticholinergic medications. A team approach to care should include a cohesive effort directed at caution against over-medication, informed management of polypharmacology, enhancement of environmental/communication supports and quality of life, and recognizing the typical nature of some depressive signs in elderly institutionalized individuals.


Haemophilia ◽  
2001 ◽  
Vol 7 (4) ◽  
pp. 428-432 ◽  
Author(s):  
S. Godreuil ◽  
R. Navarro ◽  
P. Quittet ◽  
L. Landreau ◽  
J-F. Schved ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A747-A748
Author(s):  
S DRESNER ◽  
A IMMMANUEL ◽  
P LAMB ◽  
S GRIFFIN

1982 ◽  
Vol 15 (2) ◽  
pp. 405-419
Author(s):  
James M. Malone ◽  
Wesley S. Moore

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