Soft Tissue Sarcoma Data Show Inadequate Care for the Elderly

2006 ◽  
Vol 37 (1) ◽  
pp. 36
Author(s):  
BRUCE JANCIN
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
The Elderly ◽  
Care For The Elderly ◽  
Inadequate Care

Biology of Aging

2018 ◽  
Author(s):  
Deepak Bharadia ◽  
Raquel Minasian ◽  
Indranil Sinha
Keyword(s):  
Soft Tissue ◽  
The Elderly ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Care For The Elderly ◽  
Age Related ◽  
Clinical Scenarios ◽  
Specific Tissue ◽  
Biology Of Aging ◽  
Age Related Changes

With aging, there are multiple internal and external factors that are associated with age-related changes in skin and soft tissue.  As Plastic Surgeons, we very commonly evaluate and treat elderly patients, often offering ‘anti-aging’ treatments.  An understanding of the science behind aging as well as common patterns of change seen in soft tissue may allow us to refine our treatments.  This review provides an overview of mechanisms underlying aging, as well common clinical scenarios with aging regarding anatomic sites commonly treated by Plastic Surgeons including the face, breast, and abdomen.  Separately, we discuss aging associated changes to specific tissue types, including skin, fat, muscle, and bone.  Knowledge of factors related to aging and concepts related to safe interventions to reverse or mitigate age-related changes and integral to our ability to care for the elderly population.   This review contains 9 figures, 3 tables and 69 references Key Words : Cellular senescence, mitochondrial theory, free radical theory, inflammation, protein damage hypothesis, glycation hypothesis, atrophy, lipotoxicity, rhytids, involution  

Primary soft tissue sarcoma in the elderly

2008 ◽  
Vol 68 ◽  
pp. S60
Author(s):  
R.E. Turcotte ◽  
B. Deheshi ◽  
D. Chivas ◽  
P. Ferguson ◽  
M. Isler ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
The Elderly

scholarly journals Chemotherapy and Survival in Patients with Primary High-Grade Extremity and Trunk Soft Tissue Sarcoma

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2389
Author(s):  
Danielle S. Graham ◽  
Ritchell van Dams ◽  
Nicholas J. Jackson ◽  
Mykola Onyshchenko ◽  
Mark A. Eckardt ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
High Volume ◽  
The Elderly ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Hazards Model ◽  
Multi Agent

The use of upfront chemotherapy for primary localized soft tissue sarcoma (STS) of the extremity and trunk is debated. It remains unclear if chemotherapy adds clinical benefit, which patients are likely to benefit, and whether the timing of therapy affects outcomes. We used the National Cancer Database (NCDB) to examine the association between overall survival (OS) and chemotherapy in 5436 patients with the five most common subtypes of STS with primary disease localized to the extremity or trunk, mirroring the patient population of a modern phase 3 clinical trial of neoadjuvant chemotherapy. We then examined associations between timing of multi-agent chemotherapy (neoadjuvant or adjuvant) and OS. We used a Cox proportional hazards model and propensity score matching (PSM) to account for covariates including demographic, patient, clinical, treatment, and facility factors. In the overall cohort, we observed no association between multi-agent chemotherapy or its timing and improved OS. Multi-agent chemotherapy was associated with improved OS in several subgroups, including patients with larger tumors (>5 cm), those treated at high-volume centers, or those who received radiation. We also identified an OS benefit to multi-agent chemotherapy among the elderly (>70 years) and African American patients. Multi-agent chemotherapy was associated with improved survival for patients with tumors >5 cm, who receive radiation, or who receive care at high-volume centers. Neither younger age nor chemotherapy timing was associated with better outcomes. These ‘real-world’ findings align with recent randomized trial data supporting the use of multi-agent chemotherapy in high-risk patients with localized STS.

scholarly journals Multimodality treatment of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) in the elderly

2021 ◽  
Author(s):  
Roos F. Bleckman ◽  
Ibtissam Acem ◽  
Veroniek M. van Praag ◽  
Desirée M.J. Dorleijn ◽  
Cornelis Verhoef ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Multimodality Treatment ◽  
The Elderly

136. Extremity Soft Tissue Sarcoma Care in the Elderly: A Population-Based Study

2009 ◽  
Vol 151 (2) ◽  
pp. 236
Author(s):  
W.B. Al-Refaie ◽  
E.B. Habermann ◽  
E.H. Jensen ◽  
T.M. Tuttle ◽  
S.M. Vickers ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
The Elderly ◽  
Population Based ◽  
Population Based Study ◽  
Extremity Soft Tissue Sarcoma

Extremity soft tissue sarcoma in the elderly: Are we overtreating or undertreating this potentially vulnerable patient population?

2019 ◽  
Vol 119 (8) ◽  
pp. 1087-1098 ◽  
Author(s):  
Alicia A. Gingrich ◽  
Sarah B. Bateni ◽  
Arta M. Monjazeb ◽  
Steven W. Thorpe ◽  
Amanda R. Kirane ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Patient Population ◽  
The Elderly ◽  
Extremity Soft Tissue Sarcoma ◽  
Vulnerable Patient ◽  
Vulnerable Patient Population

Extremity Soft Tissue Sarcoma Care in the Elderly: Insights into the Generalizability of NCI Cancer Trials

2010 ◽  
Vol 17 (7) ◽  
pp. 1732-1738 ◽  
Author(s):  
Waddah B. Al-Refaie ◽  
Elizabeth B. Habermann ◽  
Vikas Dudeja ◽  
Selwyn M. Vickers ◽  
Todd M. Tuttle ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
The Elderly ◽  
Extremity Soft Tissue Sarcoma ◽  
Cancer Trials

Morphological Examination of a Herpes-type Virus Indigenous for Tree Shrews

1970 ◽  
Vol 28 ◽  
pp. 160-161
Author(s):  
J. P. Brunschwig ◽  
R. M. McCombs ◽  
R. Mirkovic ◽  
M. Benyesh-Melnick
Keyword(s):  
Electron Microscopy ◽  
Soft Tissue ◽  
Chick Embryo ◽  
Soft Tissue Sarcoma ◽  
Cell Cultures ◽  
Tree Shrew ◽  
Type Virus ◽  
Morphological Examination ◽  
Tree Shrews ◽  
Embryo Cells

A new virus, established as a member of the herpesvirus group by electron microscopy, was isolated from spontaneously degenerating cell cultures derived from the kidneys and lungs of two normal tree shrews. The virus was found to replicate best in cells derived from the homologous species. The cells used were a tree shrew cell line, T-23, which was derived from a spontaneous soft tissue sarcoma. The virus did not multiply or did so poorly for a limited number of passages in human, monkey, rodent, rabbit or chick embryo cells. In the T-23 cells, the virus behaved as members of the subgroup B of herpesvirus, in that the virus remained primarily cell associated.

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