scholarly journals Long Term Follow Up of Bladder Amyloidosis

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Daniel Ensley ◽  
David Myers ◽  
George Kallingal
Keyword(s):  
Systemic Disease ◽  
Local Progression ◽  
Amyloid Deposits ◽  
Long Term Follow Up ◽  
Initial Biopsy ◽  
Bladder Amyloidosis ◽  
Term Management ◽  
Rule Out

This is an evaluation of a patient presenting with bladder amyloidosis and a seven year asymptomatic history between gross hematuria episodes. Cystoscopic evaluation showed a diffuse progression of amyloid deposits throughout the bladder. Biopsy confirmed the diagnosis and was negative for malignancy. Further evaluation ruled out systemic disease. To date, he has declined treatment. There is little available literature on long term urologic follow up for these patients. Bladder amyloidosis is rare, but most urologists will encounter it in their clinical practice. There are no agreed upon guidelines or recommendations for long term management of these patients, likely owing to its rarity. This patient had local progression confirmed on biopsy without evidence of malignancy. Evaluation for systemic amyloidosis was also negative. While a single, isolated case, it is unique for the length of follow up, the local progression and lack of symptoms. It is consistent with the low likelihood of systemic progression but does raise the question of how to treat these patients long-term. The authors recommend initial biopsy both to confirm diagnosis and rule out malignancy, evaluation for systemic disease and regular cystoscopic examinations to help direct therapy.

scholarly journals Myopericytoma in the Antitragus of the Auricle: A Rare Tumor

2020 ◽  
pp. 014556132098457
Author(s):  
Tae Seong Eo ◽  
Jeong Hae Kie ◽  
Hyun Seung Choi ◽  
Junhui Jeong
Keyword(s):  
Large Firm ◽  
Rare Tumor ◽  
Long Term Follow Up ◽  
Slow Growing ◽  
Rule Out

A myopericytoma in the auricle is rare. If an auricle contains a large, firm, red-brown mass, excision should be considered because the mass may be a myopericytoma. After excision, histopathological and immunohistochemical diagnoses are essential to rule out malignancy. Long-term follow-up is required because the tumor is slow-growing.

scholarly journals Treatment of penile lichen sclerosus with topical corticosteroids for over 25 years’ duration: A case report

2018 ◽  
Vol 6 ◽  
pp. 2050313X1879504 ◽  
Author(s):  
Matthew Howard ◽  
Anthony Hall
Keyword(s):  
Case Report ◽  
Relevant Literature ◽  
Lichen Sclerosus ◽  
Short Review ◽  
Short Term ◽  
Topical Corticosteroids ◽  
Long Term Follow Up ◽  
Term Management

Topical corticosteroids are currently recommended only for short-term management of flares of lichen sclerosus, with efficacy in halting disease progression. Given the chronic nature of this condition, there is a lack of literature surrounding the chronic effects of topical corticosteroids on the male genitalia with many dermatologists avoiding prescribing long term. This case report aims to provide anecdotal observation for the long-term use of topical corticosteroids and details the long-term follow-up of an individual who used potent and superpotent topical corticosteroids for over 25 years without significant demonstrable side effects. A short review on relevant literature is provided.

Is Breast Cancer Ever Cured? Follow-Up Study of 5623 Breast Cancer Patients

1991 ◽  
Vol 77 (6) ◽  
pp. 465-467 ◽  
Author(s):  
Stefano Ciatto ◽  
Rita Bonardi
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Systemic Disease ◽  
Cancer Death ◽  
Breast Cancer Patients ◽  
Death Rates ◽  
Breast Cancer Death ◽  
Long Term Follow Up

The authors evaluated 5623 cases of primary breast cancer followed for 1 to 21 years. Overall and breast cancer death rates were determined and compared to expected rates. Breast cancer patients showed overall and breast cancer death rates significantly higher than expected and which persisted at long-term follow-up. The observed/expected overall death ratios for follow-up periods of 0–5, 6–10, 11–15 or 16–20 years were 3.61, 2.55, 1.60 and 2.11, respectively. Death rates from breast cancer at 5, 10, 15 and 20 years were 20%, 32%, 40% and 48% respectively. The evidence of a persistent excess mortality even after long-term follow-up suggests the hypothesis that breast cancer is a systemic disease when clinically diagnosed. This study provided no evidence of a « clinical » cure for breast cancer patients. Even for N- patients the 5, 10, 15 and 20 year death rates from breast cancer were 12%, 20%, 28% and 38%, respectively. N- breast cancer, which is currently considered as a localized disease cured by surgery in most cases, would be better regarded to as a slow-growing metastatic disease, although « personal » cure may be achieved in many subjects dying of causes other than breast cancer.

Oligodendroglioma arising in the glial component of ovarian teratomas: a series of six cases and review of literature

2012 ◽  
Vol 65 (7) ◽  
pp. 631-634 ◽  
Author(s):  
Nasir Ud Din ◽  
Aisha Memon ◽  
Kanwal Aftab ◽  
Zubair Ahmad ◽  
Rashida Ahmed ◽  
...  
Keyword(s):  
Review Of Literature ◽  
Ki 67 ◽  
Who Grade ◽  
Long Term Follow Up ◽  
Grade Ii ◽  
The Right ◽  
Rule Out ◽  
Ovarian Teratomas

AimsTo report the exceedingly rare occurrence of oligodendroglioma in the glial component of ovarian teratomas.MethodsSix cases of oligodendrogliomas arising in the glial component of ovarian teratomas were studied and the literature was reviewed. Immunohistochemistry was performed by the Flex technique.ResultsThe ages of the patients ranged from 12 to 28 years (mean 21 years). Four tumours were located in the right and one in the left ovary. The size of the ovarian cysts ranged from 7 cm to 29 cm (mean 19.6 cm). Four cases arose in immature and two cases in mature teratomas. In all cases, oligodendroglioma was WHO grade II. On immunohistochemistry, glial fibrillary acidic protein stain was positive in all cases. The Mib 1 (Ki 67) proliferative index was low and the tumour cells were negative for synaptophysin. Follow-up was available in five patients and ranged from 1 to 42 months. Two patients died of disease after 1 and 36 months of diagnosis, respectively. In both these cases oligodendroglioma arose in an immature teratoma. The remaining three patients are alive with a follow-up of 4–42 months.ConclusionsOligodendroglioma arising in the glial component of ovarian teratomas is exceedingly rare. Ovarian teratomas should be extensively sampled and carefully evaluated to rule out the possibility of a glial tumour. This is the single and largest series of oligodendrogliomas arising in ovarian teratomas. The prognosis is good for oligodendrogliomas arising in mature teratomas compared with those arising in immature teratomas, although long-term follow-up is needed to determine the exact behaviour.

Idiopathic Atrophoderma of Pasini and Pierini

1997 ◽  
Vol 2 (2) ◽  
pp. 104-107
Author(s):  
Alicia Braun ◽  
James Poulton ◽  
C. Lisa Kauffman
Keyword(s):  
Case Report ◽  
Systemic Disease ◽  
Disease Entity ◽  
Long Term Follow Up ◽  
Dermal Infiltrate ◽  
Benign Course

Background: Idiopathic atrophoderma of Pasini and Pierini (LAPP) is a rare pattern of dermal atrophy, with less than 300 cases reported worldwide. Currently, there is controversy surrounding the classification of LAPP; some consider it to be a variant of morphea, while others view it as a separate disease entity. Objective: Our purpose was to further elucidate the nature and course of this unusual disease. Methods: We present a case report, with long-term follow-up of a case of IAPP of 30 years' duration. Results: The patient's lesions were primarily atrophic, without progression to morphea, scleroderma, or other systemic disease. Biopsy of a long-standing plaque demonstrated dermal thinning, and minimal dermal infiltrate. Conclusion: This case supports the findings of the literature on this subject: the majority of patients with IAPP have an entirely benign course, without progression to other disease.

A Long-Term Follow-up of Retinal Vasculitis – Do They Develop Systemic Disease?

2020 ◽  
Vol 28 (8) ◽  
pp. 1181-1186
Author(s):  
Ankush Kawali ◽  
Bharathi Bavaharan ◽  
Srinivasan Sanjay ◽  
Ashwin Mohan ◽  
Padmamalini Mahendradas ◽  
...  
Keyword(s):  
Systemic Disease ◽  
Retinal Vasculitis ◽  
Long Term Follow Up

scholarly journals A rare ophthalmic condition associated with primary hyperparathyroidism (PHPT): sclerochoroidal calcification (SC)

2019 ◽  
Vol 2019 ◽  
Author(s):  
Mona Abouzaid ◽  
Ahmed Al-Sharefi ◽  
Satish Artham ◽  
Ibrahim Masri ◽  
Ajay Kotagiri ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Observational Studies ◽  
Systemic Disease ◽  
List Type ◽  
Long Term Follow Up ◽  
Eye Examination ◽  
Learning Points ◽  
True Association

Summary An 82-year-old male with a proven diagnosis of primary hyperparathyroidism (PHPT) was found to have bilateral changes in the fundi during a routine eye examination which were consistent with SC. In this report, we discuss the link between SC and PHPT and question the need for prospective observational studies to establish the true association between these conditions. Though screening PHPT patients for SC might not be justified/warranted given the benign course of the latter, patients with SC need to be assessed for PHPT, as the former may be the first clue to an underlying treatable systemic disease. Learning points: Sclerochoroidal calcifications (SCs), though rare and harmless, could be associated with an underlying systemic disease, such as primary hyperparathyroidism (PHPT). Biochemical screening for hypercalcaemia is a simple, cheap and widely available tool that could facilitate an identification of undiagnosed PHPT in patients with SC. A joint care by endocrinologists and ophthalmologists is warranted for those patients, as thorough investigations and long-term follow-up plans are crucial.

scholarly journals Anaphylaxis in Children: Experience of an Egyptian Center

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Hesham Mohamed Ezzat ◽  
Ghada Abdel Haleem Shousha ◽  
HebatAllah Mohammed Salah Gabal ◽  
Mousa Mohamed Hani Mousa
Keyword(s):  
Children And Adolescents ◽  
Clinical Presentation ◽  
University Hospital ◽  
Early Management ◽  
Egyptian Children ◽  
Long Term Follow Up ◽  
Life Threatening ◽  
Term Management

Abstract Introduction Anaphylaxis is a potentially life threatening allergic reaction that is rapid in onset and multisystemic in nature. Distribution of anaphylaxis tends to fluctuate based on age, gender, race, geographical residence and socioeconomic status of the involved subjects. Diagnosis of anaphylaxis in children is generally underestimated particularly in developing countries, and when diagnosed, proper management is occasionally lacking. Aim of the study to evaluate the frequency and pattern of anaphylaxis and mistakes in diagnosis and treatment among a group of Egyptian children and adolescents. Subjects and methods This observational study was conducted over 12 months duration, from 1st of March 2019 to the end of February 2020, in Children’s hospital, Ain Shams University, Cairo, Egypt, on children presenting to emergency department (ED). Anaphylaxis frequency, clinical presentation, triggers, diagnosis, management and long term follow up were assessed. Results frequency rate of anaphylaxis among children and adolescents was 0.43% (80/18816) over a year. Sixty percent of patients were infants. Biphasic reactions were reported in 11.3% of patients. The commonest trigger was food (22.5%) followed by medications (8.8%). Appropriate diagnosis of anaphylaxis by junior pediatricians was reported in all patients, with epinephrine given in most occasions in proper dosage and method (78.7%). Education of children and their caregivers, providing written plan, ready-to-use epinephrine and follow up appointment were deficient. In conclusion Anaphylaxis in children was relatively high particularly in infants, with food being the most common trigger. Diagnosis and early management of anaphylaxis in our University hospital was satisfactory, however, long term management and follow up were defective.

scholarly journals Long-Term Follow-Up of SAPHO Syndrome for 15 Years Led to a Diagnosis of Temporomandibular Joint Pain and Trismus

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Koki Takamatsu ◽  
Hitoshi Sato ◽  
Takashi Moriya ◽  
Arisa Yasuda ◽  
Takaaki Kamatani ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Systemic Disease ◽  
Symptomatic Treatment ◽  
Sapho Syndrome ◽  
Sterile Inflammation ◽  
Long Term Follow Up ◽  
Tmj Pain ◽  
Long Term Prognosis

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a systemic disease with symptoms of pustular skin disease and sterile osteoarticular lesions. This disease rarely involves the temporomandibular joint (TMJ). Although it is a disease with a good long-term prognosis, its treatment remains challenging. We describe a case with long-term follow-up of SAPHO syndrome for 15 years in which TMJ pain and trismus led to the diagnosis. A 30-year-old woman with TMJ pain and trismus was referred to our department. Her medical history included palmoplantar pustulosis. Sterile inflammation in the left TMJ and diffuse sclerosing osteomyelitis of the mandible were observed. Thus, she was diagnosed with SAPHO syndrome. The symptoms of severe TMJ pain, trismus, and left cheek swelling presented three times in the 15 years. Symptomatic treatment with nonsteroidal anti-inflammatory drugs, antibiotics, corticosteroids, and bisphosphonates was administered several times. There has been no relapse of symptoms over the past nine years. The patient must be continuously kept under observation to look for the relapse of symptoms.

Solitary Extramedullary Plasmacytoma of the Oropharynx: A Rare Location

1993 ◽  
Vol 72 (11) ◽  
pp. 743-745 ◽  
Author(s):  
John Segas ◽  
Haralambos Skoulakis ◽  
George Katrinakis ◽  
Maria Tzardis
Keyword(s):  
Excisional Biopsy ◽  
Extramedullary Plasmacytoma ◽  
Light Chains ◽  
Left Posterior ◽  
Long Term Follow Up ◽  
Rare Location ◽  
Solitary Extramedullary Plasmacytoma ◽  
Rule Out

We describe a case of solitary extramedullary plasmacytoma of the oropharynx growing on the left posterior tonsillar pillar. The clinical picture was difficulty in swallowing caused from the partial obstruction of the area and bleeding from the ulcerated tumor. Lambda light chains were identified on immunohistochemical staining but they were not detected in either serum or urine (non-secreting tumor). Excisional biopsy followed by radiation therapy were used for treatment. Long-term follow up for several years is necessary in order to rule out evolution to multiple myeloma.

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