Primary bladder amyloidosis mimicking bladder cancer complicated by bladder rupture: A case report

Primary bladder amyloidosis is a rare pathological finding. The clinical importance of this finding is that it may clinically mimic bladder cancer. The only accurate diagnostic method available till now is the histopathologic examination of tissue samples usually obtained through transurethral resection.

PRIMARY BLADDER AMYLOIDOSIS - A GREAT MIMICKER OF UROTHELIAL MALIGNANCY.

Primary bladder amyloidosis is a rare condition that often mimics bladder malignancy. Here we report a case of primary bladder amyloidosis presenting as gross hematuria with clots which was managed by cystoscopy and fulguration. It is a diagnosis of exclusion usually revealed in the histopathological examination and is a relatively benign disease with better outcomes.

Long Term Follow Up of Bladder Amyloidosis

This is an evaluation of a patient presenting with bladder amyloidosis and a seven year asymptomatic history between gross hematuria episodes. Cystoscopic evaluation showed a diffuse progression of amyloid deposits throughout the bladder. Biopsy confirmed the diagnosis and was negative for malignancy. Further evaluation ruled out systemic disease. To date, he has declined treatment. There is little available literature on long term urologic follow up for these patients. Bladder amyloidosis is rare, but most urologists will encounter it in their clinical practice. There are no agreed upon guidelines or recommendations for long term management of these patients, likely owing to its rarity. This patient had local progression confirmed on biopsy without evidence of malignancy. Evaluation for systemic amyloidosis was also negative. While a single, isolated case, it is unique for the length of follow up, the local progression and lack of symptoms. It is consistent with the low likelihood of systemic progression but does raise the question of how to treat these patients long-term. The authors recommend initial biopsy both to confirm diagnosis and rule out malignancy, evaluation for systemic disease and regular cystoscopic examinations to help direct therapy.