Solitary Extramedullary Plasmacytoma of the Oropharynx: A Rare Location

1993 ◽  
Vol 72 (11) ◽  
pp. 743-745 ◽  
Author(s):  
John Segas ◽  
Haralambos Skoulakis ◽  
George Katrinakis ◽  
Maria Tzardis
Keyword(s):  
Excisional Biopsy ◽  
Extramedullary Plasmacytoma ◽  
Light Chains ◽  
Left Posterior ◽  
Long Term Follow Up ◽  
Rare Location ◽  
Solitary Extramedullary Plasmacytoma ◽  
Rule Out

We describe a case of solitary extramedullary plasmacytoma of the oropharynx growing on the left posterior tonsillar pillar. The clinical picture was difficulty in swallowing caused from the partial obstruction of the area and bleeding from the ulcerated tumor. Lambda light chains were identified on immunohistochemical staining but they were not detected in either serum or urine (non-secreting tumor). Excisional biopsy followed by radiation therapy were used for treatment. Long-term follow up for several years is necessary in order to rule out evolution to multiple myeloma.

scholarly journals Myopericytoma in the Antitragus of the Auricle: A Rare Tumor

2020 ◽  
pp. 014556132098457
Author(s):  
Tae Seong Eo ◽  
Jeong Hae Kie ◽  
Hyun Seung Choi ◽  
Junhui Jeong
Keyword(s):  
Large Firm ◽  
Rare Tumor ◽  
Long Term Follow Up ◽  
Slow Growing ◽  
Rule Out

A myopericytoma in the auricle is rare. If an auricle contains a large, firm, red-brown mass, excision should be considered because the mass may be a myopericytoma. After excision, histopathological and immunohistochemical diagnoses are essential to rule out malignancy. Long-term follow-up is required because the tumor is slow-growing.

Extramedullary Plasmacytoma of The Frontal Sinus: A Case Report

FACE ◽  
2021 ◽  
pp. 273250162110536
Author(s):  
Joshua Harrison ◽  
Samantha Marley ◽  
Shawhin Shahriari ◽  
Christian Bowers ◽  
Anil Shetty
Keyword(s):  
Frontal Sinus ◽  
Surgical Excision ◽  
Extramedullary Plasmacytoma ◽  
High Rate ◽  
Solitary Plasmacytoma ◽  
Case Presentation ◽  
Long Term Follow Up ◽  
History Of

We report a rare case of an extramedullary plasmacytoma (EMP) in the frontal sinus with an indolent clinical presentation. Although a history of trauma was absent, the initial diagnosis was a mucocele, based on the radiological findings. Upon surgical excision, the patient was found to have an EMP. EMP, a form of solitary plasmacytoma, has a significantly high rate of conversion to multiple myeloma. This mandates long-term follow-up, even after successful radiotherapy and/or resection. While radiation therapy is generally considered a first line treatment for EMP, surgical intervention may provide optimal treatment in complicated cases. This case presentation highlights the prognosis of patients diagnosed with EMP.

scholarly journals Primary Tuberculous Lymphadenitis: a Rare Case Report

2018 ◽  
Vol 22 (2) ◽  
pp. 106-110
Author(s):  
Mustafa Mert Açikgöz ◽  
Ayşem Yurtseven ◽  
Gülsüm Ak
Keyword(s):  
Case Report ◽  
Multidisciplinary Approach ◽  
Maxillofacial Surgery ◽  
Excisional Biopsy ◽  
Oral And Maxillofacial Surgery ◽  
Tuberculous Lymphadenitis ◽  
Rare Case Report ◽  
Long Term Follow Up

SummaryBackground/Aim: Our aim is to describe multidisciplinary approach to primary tuberculous lymphadenitis with a case report.Case Report: A 6-year-old boy was referred to İstanbul University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery with the symptoms of painless extra-oral abscess and lymphadenopathy. The diagnosis of primary tuberculous lymphadenitis was proved by microbiological culture and ultrasound imaging.Conclusions: Combine tuberculosis treatment should be applied and long term follow up is necessary. Excisional biopsy for tissue diagnosis and bacterial examination with culture should be performed for an early diagnosis as a delay in treatment can lead to devastating consequences.

Extramedullary Nasal Plasmacytoma — An Unusual Clinical Entity

1996 ◽  
Vol 75 (3) ◽  
pp. 171-173 ◽  
Author(s):  
Gordon Soo ◽  
Anthony Chan ◽  
Dennis Lam ◽  
Victor Abdullah ◽  
C. Andrew van Hasselt
Keyword(s):  
World Literature ◽  
Residual Disease ◽  
Disease Recurrence ◽  
Extramedullary Plasmacytoma ◽  
Intracranial Extension ◽  
Long Term Follow Up ◽  
Unusual Appearance

A case of extramedullary plasmacytoma with its unusual appearance is reported. This is the second reported case in world literature affecting the paranasal sinuses with intracranial extension. The role of surgery is to obtain tissue for diagnosis and to excise residual disease. Radiotherapy is the treatment of choice and long-term follow-up is necessary for monitoring disease recurrence. The overall 10-year survival is about 50%. The case is discussed with a general review of the management of this pathology.

Multiple Spinal Perimedullary Arteriovenous Fistulae Associated with the Parkes-Weber Syndrome

1998 ◽  
Vol 4 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Y. Niimi ◽  
U. Ito ◽  
O. Tone ◽  
K. Yoshida ◽  
S. Sato ◽  
...  
Keyword(s):  
Lower Extremities ◽  
Arteriovenous Fistulae ◽  
Left Posterior ◽  
Weber Syndrome ◽  
Long Term Follow Up ◽  
History Of ◽  
One Year ◽  
Polyvinyl Alcohol Particles

We present a rare case of multiple spinal perimedullary arteriovenous fistulae associated with the Parkes-Weber (PW) syndrome. A 31-year-old male known to have the PW syndrome involving the left leg since birth, presented with a 7-month-history of progressive myelopathy of the lower extremities and dysfunction of the bladder and bowel. Myelography demonstrated dilated intradural vessels. Angiography demonstrated two distinct single hole perimedullary arteriovenous fistulae near the conus at two different metameres. They were supplied by the left posterior spinal artery. The patient was treated by transarterial embolisation using polyvinyl alcohol particles, which resulted in venous side occlusion of the fistulae. After the treatment, the patient developed transient worsening of the spasticity of the lower extremities, and was treated by heparinization. After heparinization, the patient partially recovered from the pre-embolisation status of his myelopathy. The follow-up angiogram one year after the embolisation demonstrated persistent obliteration of both fistulae. At long-term follow-up, the patient can ambulate without assistance and work as a farmer.

Oligodendroglioma arising in the glial component of ovarian teratomas: a series of six cases and review of literature

2012 ◽  
Vol 65 (7) ◽  
pp. 631-634 ◽  
Author(s):  
Nasir Ud Din ◽  
Aisha Memon ◽  
Kanwal Aftab ◽  
Zubair Ahmad ◽  
Rashida Ahmed ◽  
...  
Keyword(s):  
Review Of Literature ◽  
Ki 67 ◽  
Who Grade ◽  
Long Term Follow Up ◽  
Grade Ii ◽  
The Right ◽  
Rule Out ◽  
Ovarian Teratomas

AimsTo report the exceedingly rare occurrence of oligodendroglioma in the glial component of ovarian teratomas.MethodsSix cases of oligodendrogliomas arising in the glial component of ovarian teratomas were studied and the literature was reviewed. Immunohistochemistry was performed by the Flex technique.ResultsThe ages of the patients ranged from 12 to 28 years (mean 21 years). Four tumours were located in the right and one in the left ovary. The size of the ovarian cysts ranged from 7 cm to 29 cm (mean 19.6 cm). Four cases arose in immature and two cases in mature teratomas. In all cases, oligodendroglioma was WHO grade II. On immunohistochemistry, glial fibrillary acidic protein stain was positive in all cases. The Mib 1 (Ki 67) proliferative index was low and the tumour cells were negative for synaptophysin. Follow-up was available in five patients and ranged from 1 to 42 months. Two patients died of disease after 1 and 36 months of diagnosis, respectively. In both these cases oligodendroglioma arose in an immature teratoma. The remaining three patients are alive with a follow-up of 4–42 months.ConclusionsOligodendroglioma arising in the glial component of ovarian teratomas is exceedingly rare. Ovarian teratomas should be extensively sampled and carefully evaluated to rule out the possibility of a glial tumour. This is the single and largest series of oligodendrogliomas arising in ovarian teratomas. The prognosis is good for oligodendrogliomas arising in mature teratomas compared with those arising in immature teratomas, although long-term follow-up is needed to determine the exact behaviour.

scholarly journals Solitary Extramedullary Plasmacytoma Presenting as Asymptomatic Palatal Erythroplakia: Report of a Case

2021 ◽  
Vol 18 (7) ◽  
pp. 3762
Author(s):  
Francesca Lalla ◽  
Alessandro Vinciguerra ◽  
Alessandra Lissoni ◽  
Gianluigi Arrigoni ◽  
Francesca Lira Luce ◽  
...  
Keyword(s):  
Plasma Cells ◽  
Excisional Biopsy ◽  
Extramedullary Plasmacytoma ◽  
Definitive Diagnosis ◽  
Solitary Plasmacytoma ◽  
Systemic Spread ◽  
Solitary Bone Plasmacytoma ◽  
Immunohistochemical Studies ◽  
Solitary Extramedullary Plasmacytoma

Solitary plasmacytoma (SP) is a rare malignant tumor of plasma cells with no systemic spread; however, when it disseminates and affects multiple skeletal sites, it is called multiple myeloma (MM). The etiology of solitary plasmacytoma is unknown, with two possible subtypes: solitary extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP). We present a case of EMP arising as asymptomatic erythroplakia of the palate, which is rarely described in the literature. The definitive diagnosis was obtained with immunohistochemical studies, after which the lesion was subjected to excisional biopsy. At present, after two years of close follow-up, the patient has shown no signs of relapse or conversion to MM. The uniqueness of the case highlights the possibility of an atypical EMP lesion in the head and neck, thus posing a diagnostic and therapeutic challenge for physicians.

scholarly journals Recurrence of Ameloblastic Fibro-Odontoma in a Child: A Case Report

2020 ◽  
Vol 5 ◽  
pp. 247275122090484
Author(s):  
Raphael Capelli Guerra ◽  
Pedro Henrique de Azambuja Carvalho ◽  
Florian Markus Thieringer ◽  
Rodrigo Santos Pereira ◽  
Eduardo Hochuli-Vieira
Keyword(s):  
Case Report ◽  
Maxillofacial Surgery ◽  
Bone Lesion ◽  
Benign Neoplasm ◽  
Excisional Biopsy ◽  
Oral And Maxillofacial Surgery ◽  
Local Inflammation ◽  
Long Term Follow Up

Introduction: A young boy presented with mandibular swelling at the Department of Oral and Maxillofacial Surgery in Hospital Leforte, São Paulo, Brazil. Radiography showed a mixed bone lesion. Computed tomography (CT) findings were compatible with ameloblastic fibro-odontoma (AFO). Case Report: An excisional biopsy was performed under general anesthesia. At the 6-year follow-up, local inflammation and mild exudates were found. Local recurrence of the lesion was observed on CT. Therefore, excision and curettage were performed. No signs of recurrence have been detected to date. Ameloblastic fibro-odontoma is a rare benign neoplasm most commonly occurring in the first decade of life, with minimal probability of malignancy. Conclusion: Clinical, radiological, and histopathological findings aid in the diagnosis, and long-term follow-up is necessary as recurrence can develop even after 6 postoperative years.

scholarly journals Long Term Follow Up of Bladder Amyloidosis

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Daniel Ensley ◽  
David Myers ◽  
George Kallingal
Keyword(s):  
Systemic Disease ◽  
Local Progression ◽  
Amyloid Deposits ◽  
Long Term Follow Up ◽  
Initial Biopsy ◽  
Bladder Amyloidosis ◽  
Term Management ◽  
Rule Out

This is an evaluation of a patient presenting with bladder amyloidosis and a seven year asymptomatic history between gross hematuria episodes. Cystoscopic evaluation showed a diffuse progression of amyloid deposits throughout the bladder. Biopsy confirmed the diagnosis and was negative for malignancy. Further evaluation ruled out systemic disease. To date, he has declined treatment. There is little available literature on long term urologic follow up for these patients. Bladder amyloidosis is rare, but most urologists will encounter it in their clinical practice. There are no agreed upon guidelines or recommendations for long term management of these patients, likely owing to its rarity. This patient had local progression confirmed on biopsy without evidence of malignancy. Evaluation for systemic amyloidosis was also negative. While a single, isolated case, it is unique for the length of follow up, the local progression and lack of symptoms. It is consistent with the low likelihood of systemic progression but does raise the question of how to treat these patients long-term. The authors recommend initial biopsy both to confirm diagnosis and rule out malignancy, evaluation for systemic disease and regular cystoscopic examinations to help direct therapy.

scholarly journals P.043 Long term MS clinical outcomes predicted by baseline serum neurofilament light levels

2021 ◽  
Vol 48 (s3) ◽  
pp. S32-S32
Author(s):  
M Abdoli ◽  
S Thebault ◽  
MS Freedman ◽  
D Tessier ◽  
V Tobbard-Cossa ◽  
...  
Keyword(s):  
Predictive Marker ◽  
Light Chains ◽  
Neurofilament Light ◽  
Baseline Serum ◽  
Light Levels ◽  
Median Serum ◽  
Disease Modifying Treatment ◽  
Rule Out

Background: Prognostic biomarkers are badly needed to direct MS treatment intensity early in the condition Levels of serum neurofilament light chains (sNfL) result from the destruction of central nervous system axons in MS and correlate with the aggressiveness of the disease. Methods: In this prospective cohort study, we identified patients with serum collected within 5 years of first MS symptom onset with more than 15 years of clinical follow-up. Levels of sNfL were quantified in patients and matched controls using digital immunoassay. Results: Sixty-seven patients had a median follow-up period of 17.4 years (range:15.1-26.1). Median serum NfL levels in baseline samples of MS patients was 10.1 pg/ml, 38.5% higher than median levels in 37 controls (7.26pg/ml, p=0.004). Baseline NfL level was most helpful as a predictive marker to rule out progression; patients with levels less 7.62pg/ml were 4.3 times less likely to develop an EDSS score of 34 (p=0.001) and 7.1 times less likely to develop progressive MS (p=0.054). Patients with the highest NfL levels (3rd-tertile, >13.2 pg/ml) progressed most rapidly with an EDSS annual rate of 0.16 (p=0.004), remaining significant after adjustment for sex, age, and disease-modifying treatment (p=0.022). Conclusions: This study demonstrates that baseline sNfL is associated with long term disease progression.

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