Status of Antioxidant Enzymes and Lipid Peroxidation in Type 2 Diabetes Mellitus with Neuropathy

2005 ◽  
Vol 12 (03) ◽  
pp. 49-52 ◽  
Author(s):  
Manjulata Kumawant ◽  
Neelima Singh ◽  
Sanjeev Singh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Peroxidation ◽  
Type 2 Diabetes Mellitus ◽  
Antioxidant Enzymes

scholarly journals Antioxidant enzymes and lipid peroxidation in type 2 diabetes mellitus patients with and without nephropathy

2013 ◽  
Vol 5 (3) ◽  
pp. 213 ◽  
Author(s):  
TarunKumar Sharma ◽  
Ishwar Singh ◽  
Neelima Singh ◽  
GhalautKumar Vardey ◽  
Manjulata Kumawat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Peroxidation ◽  
Type 2 Diabetes Mellitus ◽  
Antioxidant Enzymes

A Study of Lipid Peroxidation and Antioxidants in Patients with Type 2 Diabetes Mellitus with and without Neuropathy

2015 ◽  
Vol 3 (1) ◽  
pp. 71
Author(s):  
Sunita Pujar ◽  
Kavitha Hiremath ◽  
LL Pujar ◽  
Neela B Mannangi ◽  
Mahanthesh Bhuthal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Peroxidation ◽  
Type 2 Diabetes Mellitus

scholarly journals Lipid Peroxidation and Antioxidant Status in Nonobese Type 2 Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Vineet Kumar Khemka ◽  
Subhadip Choudhuri ◽  
Anirban Ganguly ◽  
Arindam Ghosh ◽  
Aritri Bir ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Peroxidation ◽  
Type 2 Diabetes Mellitus ◽  
Antioxidant Status ◽  
Mononuclear Cells ◽  
Inverse Correlation ◽  
Significant Inverse Correlation ◽  
Total Thiol

The aim of the study was to investigate the association between lipid peroxidation and antioxidant status in nonobese type 2 diabetes mellitus (T2DM) and further to correlate whether their significant association is putatively associated with the pathogenesis of T2DM. A number of 102 nonobese T2DM subjects and 95 nondiabetic subjects as healthy controls were enrolled in this cross-sectional study. Serum samples were collected in cryovials for malondialdehyde (MDA) and thiol assays. Total thiol or sulfhydryl (–SH) groups in peripheral blood mononuclear cells (PBMCs) and sera, as well as level of MDA, a marker for lipid peroxidation in serum, were measured spectrophotometrically. Serum MDA level was found significantly higher whereas serum and PBMC total thiol levels were diminished significantly among nonobese T2DM subjects compared to HC subjects. Moreover, serum MDA level is found to have a significant inverse correlation with serum total thiol and PBMC thiol levels among DM subjects, but no significant correlation was observed in HC individuals. A significant inverse correlation between serum MDA and serum total thiol levels among nonobese T2DM subjects suggests a close association of increased oxidative stress with decreased antioxidant status in nonobese T2DM.

scholarly journals Paraoxonase activity and lipid peroxidation in female patients with type 2 diabetes mellitus and without coronary heart disease

2003 ◽  
Vol 49 (1) ◽  
pp. 17-20
Author(s):  
M. Yu. Gorshunskaya.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Peroxidation ◽  
Coronary Heart Disease ◽  
Type 2 Diabetes Mellitus ◽  
Heart Disease ◽  
High Density ◽  
High Density Lipoproteins ◽  
Paraoxonase Activity

The rate of lipid peroxidation and the parameters of antioxida- tive defense, including the activity of paraoxonase that is essen­tial for the prevention of low-density lipoprotein oxidation, was studied in 229female patients with type 2 diabetes mellitus with and without coronary heart disease (CHD) under varying glyc­emic control. Carbohydrate and lipid metabolisms were explored by unified biochemical studies, blood insulin levels were meas­ured by radioimmunological assay. The activity of paraoxonase associated with high-density lipoproteins of ester hydrolase was spectrophotometrically determined by using paraoxan as a sub­strate. Along with dyslipoproteinemia and insulin resistance, there was a drastically reduced paraoxonase activity that was as­sociated with the high-density lipoproteins of the antioxidant en­zyme and more pronounced in diabetics with CHD. A highly sig­nificant inverse correlation of the activity of the enzyme with the rate of lipid peroxidation and a less close relationship to basal glycemia have been verified, which substantiates the polygenic nature of decreased paraoxonase activity in diabetes mellitus.

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