scholarly journals Osteocalcin and Abdominal Aortic Calcification in Hemodialysis Patients: An Observational Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Fengyu Jia ◽  
Suxia Wang ◽  
Ying Jing ◽  
Hanhui Zhao ◽  
Peng Rong ◽  
...  
Keyword(s):  
Vascular Calcification ◽  
Negative Correlation ◽  
Pearson Correlation ◽  
Fibroblast Growth Factor 23 ◽  
Cross Sectional Study ◽  
Aortic Calcification ◽  
Maintenance Hemodialysis ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic

ObjectivesTo investigate the serum level of osteocalcin (OC), also known as bone Gla protein, in maintenance hemodialysis (MHD) patients and its correlation with abdominal aortic calcification (AAC).MethodsFrom July 2017 to February 2020, we enrolled 108 adult MHD patients. Routine fasting blood laboratory tests were performed before the start of the second hemodialysis in a week. Abdominal aortic calcification score (AACs) was assessed within 1 month. Pearson correlation and Logistic regression were used to analyze the data.ResultsThe OC level was 231.56 (25.92,361.33) ng/ml, elevating significantly in this group of MHD patients. It had a positive correlation with serum phosphorus (r = 0.511, P = 0.001), intact parathyroid hormone(iPTH) (r = 0.594, P = 0.0001), fibroblast growth factor 23(FGF23) (r = 0.485, P = 0.003) and a negative correlation with age(r = -0.356, P = 0.039). Based on the AACs, patients were divided into two groups. Serum OC level were higher in patients with AACs≥5 (p=0.032). A multiple logistics regression analysis revealed that age (odds ratio [OR]1.14, P=0.005) and OC(OR=1.10, P=0.008)were risk factors for high AACs(≥5).ConclusionThe study implicated that OC elevated significantly in this group of MHD patients.OC is positively correlated with phosphorus, iPTH, FGF23, and a negative correlation with age. OC was a risk factor for vascular calcification in this study, but this study did not classify osteocalcin as c-OC and unOC. Whether unOC is associated more directly with vascular calcification requires further study.

scholarly journals Proton pump inhibitor as an independent factor of progression of abdominal aortic calcification in patients on maintenance hemodialysis

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0199160 ◽  
Author(s):  
Teppei Okamoto ◽  
Shingo Hatakeyama ◽  
Shogo Hosogoe ◽  
Yoshimi Tanaka ◽  
Kengo Imanishi ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Aortic Calcification ◽  
Maintenance Hemodialysis ◽  
Independent Factor ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic
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