scholarly journals The effect of ezetimibe monotherapy on lipoprotein-(a) and other lipid parameters

2015 ◽  
Author(s):  
Bülent Bilir ◽  
Betül Ekiz Bilir ◽  
Mümtaz Takır ◽  
Yaşar Sertbaş ◽  
Can Murat Akıncı ◽  
...  
Keyword(s):  
Lipoprotein A ◽  
Lipid Parameters

scholarly journals Lipoprotein (a) as a Predictor of Steroid Dependence in Paediatric Steroid Sensitive Nephrotic Syndrome

2021 ◽  
Author(s):  
Surupa Basu ◽  
Sushmita Banerjee ◽  
Pranab Roy ◽  
Apurba Ghosh
Keyword(s):  
Nephrotic Syndrome ◽  
First Episode ◽  
Urine Protein ◽  
Lipoprotein A ◽  
Steroid Dependence ◽  
Steroid Dependency ◽  
Steroid Dependent ◽  
Steroid Sensitive ◽  
One Year ◽  
Lipid Parameters

Introduction: Lipoprotein a {Lp(a)} increases in Nephrotic Syndrome (NS). Although the majority of paediatric NS are steroid sensitive, relpase and steroid dependence are commonly seen in this cases. Lp(a) is an LDL-like lipoprotein that consists of an LDL particle to which the glycoprotein apolipoprotein(a) {apo(a)} is attached. Aim: To evaluate the potential of Lp(a), measured on admission, for the prediction of relapse/steroid dependency. Materials and Methods: Children (n=36) with first episode NS were recruited in this prospective observational case-control study and followed up for one year. They were tested at presentation for Lp(a) (mg/dL) and standard tests such as haemoglobin, albumin, protein, cholesterol, triglyceride, and urine protein. Children received standard therapy for NS, and were followed for a period of one year from diagnosis to record days to initial remission, relapse episodes, steroid dependence etc. Patients were categorised as: no relapse (NR), Infrequent Relapse (IFR), frequent relapse (FR) and Steroid Dependent (SD) as per standard definitions. Fifteen healthy volunteers were also tested for lipid profile and Lp(a) levels. Results: Of 36 cases (median age 3 years, 19 males), there were 15NR, 7IFR, 2FR and 12SD. The mean Lp(a) of the NS group (165.2±120.4 mg/dL) was higher than controls (30.52±21.9 mg/dL) (p<0.0001). All the lipid parameters except HDL-cholesterol were significantly higher in the NS group. Within the NS group, Lp(a) showed significant correlation (Spearman-rho) with albumin (p=0.0062,r=0.47), but no correlation with lipid parameters or urine protein. Comparison of Lp(a)levels in the NS groups revealed that the SD patients had a high Lp(a)(222.0±115.7 mg/dL) compared to NR (129.7±120.1 mg/dL) (p=0.02). Conclusion: Concentration of plasma Lp(a) in patients with SDNS was higher compared to patients who did not suffer any relapse, and this concentration may serve as a marker for prediction of SDNS.

Profile of lipoprotein(a) and lipid parameters in acute ischemic stroke

2003 ◽  
Vol 12 (5) ◽  
pp. 248
Author(s):  
H. Tandon ◽  
O.P. Kalra ◽  
G. Singh ◽  
J. Gambhir ◽  
G. Mehrotra
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Lipoprotein A ◽  
Lipid Parameters

scholarly journals Live donor study - implications of kidney donation on cardiovascular risk with a focus on lipid parameters including lipoprotein a

Nephrology ◽  
2016 ◽  
Vol 21 (10) ◽  
pp. 901-904 ◽  
Author(s):  
Brian Doucet ◽  
Karam Kostner ◽  
Omar Kaiser ◽  
Carmel Hawley ◽  
Nicole Isbel
Keyword(s):  
Cardiovascular Risk ◽  
Kidney Donation ◽  
Live Donor ◽  
Lipoprotein A ◽  
Lipid Parameters

scholarly journals Lipoprotein (a) levels, apolipoprotein (a) phenotypes and thyroid autoimmunity

1999 ◽  
pp. 474-476 ◽  
Author(s):  
ET Bairaktari ◽  
AD Tselepis ◽  
HJ Millionis ◽  
MS Elisaf
Keyword(s):  
Molecular Weight ◽  
Thyroid Autoimmunity ◽  
Inverse Correlation ◽  
Serum Lipoprotein ◽  
Control Group ◽  
Lipoprotein A ◽  
Apolipoprotein A ◽  
Median Serum ◽  
Lipid Parameters ◽  
Age And Sex

It has been reported that euthyroid normolipidemic males and postmenopausal females exhibit significantly higher serum lipoprotein (a) (Lp(a)) levels compared with age- and sex-matched normolipidemic controls. However, it is well known that there is an inverse correlation between Lp(a) concentration and apolipoprotein (a) (apo(a)) isoform size. Thus, it is imperative to exclude differences in apo(a) isoform frequencies between subjects with or without thyroid autoimmunity in order to verify if there is an association between thyroid autoimmunity and increased Lp(a) concentration. To exclude such an effect of different apo(a) isoform frequencies, we determined apo(a) phenotypes in 22 patients (9 males and 13 postmenopausal females) with thyroid autoimmunity and in 64 (29 males and 35 females) age- and sex-matched individuals without thyroid autoimmunity (control group). There were no significant differences in the values of lipid parameters between the two groups, including Lp(a). We did not detect any significant differences in the apo(a) phenotype frequencies between the two groups. Additionally, in neither of the subgroups formed according to the presence of low molecular vs high molecular weight apo(a) isoforms were there any significant differences in median serum Lp(a) levels between patients with and without thyroid autoimmunity. Thus, our results contradict the previously reported association between thyroid autoimmunity and Lp(a) concentrations.

2.P.170 Nandrolone decanoate reduces lipoprotein(a) levels without effect on other lipid parameters

1997 ◽  
Vol 134 (1-2) ◽  
pp. 152
Author(s):  
B.H.R. Wolffenbuttel ◽  
F. Hartgens ◽  
G. Rietjens ◽  
H.A. Keizer ◽  
H. Kuipers
Keyword(s):  
Nandrolone Decanoate ◽  
Lipoprotein A ◽  
Lipid Parameters

Lipid Parameters Including Lipoprotein (A) in Patients Undergoing CAPD and Hemodialysis

1995 ◽  
Vol 15 (4) ◽  
pp. 342-347 ◽  
Author(s):  
Kostas C. Siamopoulos ◽  
Moses S. Elisaf ◽  
Helen T. Bairaktari ◽  
Michael B. Pappas ◽  
George D. Sferopoulos ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Outcome Measures ◽  
Smoking Habits ◽  
Dialysis Patients ◽  
Lipoprotein A ◽  
Atherogenic Lipid Profile ◽  
Lipid Parameters ◽  
Risk Ratios ◽  
Atherogenic Lipid

Objective Oyslipidemia possibly contributes to the vascular complications commonly afflicting uremic patients. Lipoprotein (a) [Lp(a)] has been identified as an independent risk factor for atherosclerotic vascular dis ease. The aim of our study was to compare lipidparameters, including Lp(a), between hemodialysis (HO) and continuous ambulatory peritoneal dialysis (CAPO) patients. Design A cross-sectional study. Setting University Medical Center. Participants Forty CAPO and 40 HO patients carefully matched for age, sex, body mass index (BMI), smoking habits, and duration of dialysis were studied. A group of 40 healthy individuals matched for age, sex, BMI, and smoking habits was used as control. Interventions None. Main Outcome Measures Serum lipid parameters and atherogenic risk ratios were the main outcome measures. Results Both groups of dialysis patients had increased serum triglycerides and decreased levels of Apo AI and HOL cholesterol compared to controls. Moreover, the risk ratios total cholesterol/HOL cholesterol and LOL cholesterol/HOL cholesterol were significantly higher, and the ratio ApoA1/ApoB was significantly lower in both groups of patients in comparison to the normal subjects. Both groups of dialysis patients exhibited decreased ratios of LOL cholesterol/ApoB and HOL cholesterol/ApoAI, suggesting the presence of compositional lipoprotein changes. CAPO patients had a more atherogenic lipid profile compared to HO patients, since they exhibited higher levels of total and LOL cholesterol, of ApoB as well as of the ratios total cholesterol/HOL cholesterol and LOL cholesterol/ HOL cholesterol, and lower levels of the ratio ApoA1/ApoB compared to HO patients. Both groups of dialysis patients had increased serum Lp(a) levels. Even though CAPO patients had higher serum Lp(a) levels than HO patients, the differences between these two groups were only marginally statistically significant (p = 0.056 by Mann-Whitney U-test). Uremic dyslipidemia was positively correlated with serum albumin levels in both groups of patients. Conclusion CAPO patients exhibit a more atherogenic lipid profile than that of HO patients. The marked disturbances in Lp(a) levels may further increase the vascular risk in both groups of patients.

scholarly journals The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
D. O. Yetkin ◽  
B. Dogantekin
Keyword(s):  
Thyroid Autoimmunity ◽  
Vascular Diseases ◽  
Hashimoto Thyroiditis ◽  
Control Group ◽  
Thyroid Function Tests ◽  
Lipoprotein A ◽  
Sh Group ◽  
Premenopausal Female ◽  
The Relationship ◽  
Lipid Parameters

Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relationship between Lp(a) levels and thyroid hormones in Hashimoto patients.Method. 154 premenopausal female Hashimoto patients (48 patients with overthypothyroid (OH), 50 patients with subclinical hypothyroid (SH), and 56 patients with euthyroid Hashimoto to (EH)) were enrolled in this study. The control group consists of 50 age matched volunteers. In every group, thyroid function tests and lipid parameters with Lp(a) were measured. Lp(a) excess was defined as Lp(a) > 30 mg/dL.Results. Total-C, LDL-C, TG, and Lp(a) levels were increased in Hashimoto group. Total-C, LDL-C, and TG levels were higher in SH group than in the control group. Total-C and LDL-C levels were also higher in EH group compared to controls. Lp(a) levels were similar in SH and EH groups with controls. However, excess Lp(a) was more common in subclinical hypothyroid and euthyroid Hashimoto group than in the control group.Conclusion. The Total-C and LDL-C levels and excess Lp(a) were higher even in euthyroid Hashimoto patients. Thyroid autoimmunity may have some effect on Lp(a) and lipid metabolism.

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