The Strict Concept of Specificity as Multiple Sclerosis Pathogenesis

2020 ◽  
Author(s):  
Lawrence M. Agius
Keyword(s):  
Multiple Sclerosis ◽  
Multiple Sclerosis Pathogenesis

scholarly journals Radical changes in multiple sclerosis pathogenesis

2011 ◽  
Vol 1812 (2) ◽  
pp. 141-150 ◽  
Author(s):  
Jack van Horssen ◽  
Maarten E. Witte ◽  
Gerty Schreibelt ◽  
Helga E. de Vries
Keyword(s):  
Multiple Sclerosis ◽  
Multiple Sclerosis Pathogenesis

Multiple sclerosis pathogenesis: missing pieces of an old puzzle

2018 ◽  
Vol 30 (1) ◽  
pp. 67-83 ◽  
Author(s):  
Reza Rahmanzadeh ◽  
Wolfgang Brück ◽  
Alireza Minagar ◽  
Mohammad Ali Sahraian
Keyword(s):  
Multiple Sclerosis ◽  
Cd8 T Cells ◽  
Autoimmune Encephalitis ◽  
Cd4 T Cell ◽  
Experimental Autoimmune Encephalitis ◽  
Focal Lesions ◽  
Multiple Sclerosis Pathogenesis ◽  
Cns Autoimmunity ◽  
Ms Pathogenesis ◽  
Experimental Autoimmune

Abstract Traditionally, multiple sclerosis (MS) was considered to be a CD4 T cell-mediated CNS autoimmunity, compatible with experimental autoimmune encephalitis model, which can be characterized by focal lesions in the white matter. However, studies of recent decades revealed several missing pieces of MS puzzle and showed that MS pathogenesis is more complex than the traditional view and may include the following: a primary degenerative process (e.g. oligodendroglial pathology), generalized abnormality of normal-appearing brain tissue, pronounced gray matter pathology, involvement of innate immunity, and CD8 T cells and B cells. Here, we review these findings and discuss their implications in MS pathogenesis.

Unraveling a new player in multiple sclerosis pathogenesis: The RNA-binding protein HuR

2020 ◽  
Vol 41 ◽  
pp. 102048 ◽  
Author(s):  
Cristiana Pistono ◽  
Maria Cristina Monti ◽  
Nicoletta Marchesi ◽  
Chiara Boiocchi ◽  
Lucrezia Irene Maria Campagnoli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Multiple Sclerosis Pathogenesis
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