scholarly journals Observational Histopathological Analysis of Renal Lesions in Nephrectomy Specimens

2021 ◽  
Vol 8 (4) ◽  
pp. 18-21
Author(s):  
Anita Kumari ◽  
Sarmistha Subhadarsini ◽  
U S Pandey
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Care Center ◽  
Chronic Pyelonephritis ◽  
Histopathological Analysis ◽  
Surgical Department ◽  
Health Care Center ◽  
Renal Lesions ◽  
Malignant Lesions

Aim: This observational retrospective study was initiated to perform histopathological spectrum analysis of renal lesions from resected nephrectomy specimens. Materials and Methods: This was a retrospective observational study. Over a span of 4 years a total of 62 nephrectomy cases who underwent nephrectomy in a tertiary health care center and specimens were received from the surgical Department of the Hospital were analysed. Microscopic and gross features of the specimen were studied. Result: 12(19%) nephrectomy specimens out of 62 were malignant and 50 (81%) were benign. The mean age of patients from whom specimen were collected was 44.16 ± 29.8 years. 34 (54.9%) were Chronic Pyelonephritis cases, some associated with hydronephrosis and others with calculi. Out of 12 total malignant lesions 8 cases (12.9%) constituted as renal cell carcinoma. Among children commonest malignant tumour was Wilm’s tumour. Among the clinical presentation most common was flank pain in 17 (53.1%) cases followed by fever and burning micturition. Conclusion: In current study as compared to the benign tumours, malignant renal tumours far outnumbered. In paediatric age group most common malignancy was the Wilms tumour. Most common histomorphological diagnosis was Chronic Pyelonephritis and among the malignant lesions commonest were Renal Cell Carcinoma. Keywords: Nephrectomy, Histopathology, Chronic Pyelonephritis, Wilm’s tumour, Renal Cell Carcinoma.

scholarly journals Quantitative 3-tesla multiparametric MRI in differentiation between renal cell carcinoma subtypes

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Ali Elsorougy ◽  
Hashim Farg ◽  
Dalia Bayoumi ◽  
Mohamed Abou El-Ghar ◽  
Magda Shady
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Multiparametric Mri ◽  
Histopathological Analysis ◽  
Adc Value ◽  
Intensity Index ◽  
Apparent Diffusion ◽  
The Mean

Abstract Background MRI provides several distinct quantitative parameters that may better differentiate renal cell carcinoma (RCC) subtypes. The purpose of the study is to evaluate the diagnostic accuracy of apparent diffusion coefficient (ADC), chemical shift signal intensity index (SII), and contrast enhancement in differentiation between different subtypes of renal cell carcinoma. Results There were 63 RCC as regard surgical histopathological analysis: 43 clear cell (ccRCC), 12 papillary (pRCC), and 8 chromophobe (cbRCC). The mean ADC ratio for ccRCC (0.75 ± 0.13) was significantly higher than that of pRCC (0.46 ± 0.12, P < 0.001) and cbRCC (0.41 ± 0.15, P < 0.001). The mean ADC value for ccRCC (1.56 ± 0.27 × 10−3 mm2/s) was significantly higher than that of pRCC (0.96 ± 0.25 × 10−3 mm2/s, P < 0.001) and cbRCC (0.89 ± 0.29 × 10−3 mm2/s, P < 0.001). The mean SII of pRCC (1.49 ± 0.04) was significantly higher than that of ccRCC (0.93 ± 0.01, P < 0.001) and cbRCC (1.01 ± 0.16, P < 0.001). The ccRCC absolute corticomedullary enhancement (196.7 ± 81.6) was significantly greater than that of cbRCC (177.8 ± 77.7, P < 0.001) and pRCC (164.3 ± 84.6, P < 0.001). Conclusion Our study demonstrated that multiparametric MRI is able to afford some quantitative features such as ADC ratio, SII, and absolute corticomedullary enhancement which can be used to accurately distinguish different subtypes of renal cell carcinoma.

Pulmonary metastasectomy in renal cell carcinoma: Predictive and prognostic elements from paired histopathological analysis of primary tumors and respective metastases

2021 ◽  
pp. 239936932110285
Author(s):  
Melissa Bersanelli ◽  
Sebastiano Buti ◽  
Letizia Gnetti ◽  
Elena Varotti ◽  
Paolo Carbognani ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Positive Impact ◽  
Left Lung ◽  
Pulmonary Metastasectomy ◽  
Histopathological Analysis ◽  
Primary Tumors ◽  
Paired Samples

Objective: To identify histopathological and immunophenotypical features with potential predictive or prognostic value in patients undergoing pulmonary metastasectomy from renal cell carcinoma (RCC). Methods: We retrospectively collected all consecutive patients undergoing pulmonary metastasectomy from RCC after prior nephrectomy. Paired samples of primary tumors and corresponding pulmonary metastases were analyzed, revising histopathological features and testing C-MET, mTOR, and PD-L1 by immunohistochemistry. Results: A total of 25 patients were included. Median overall survival (mOS) from metastasectomy was 5.5 years (95% CI = 1.9–9.1). The laterality of metastases had a significant predictive value, with median relapse-free survival (mRFS) from metastasectomy not reached (NR) at mean follow-up (FU) of 60.8 months for left lung involvement, mRFS of 52.9 months (95% CI = 0–145.5) for the right lung and 6.4 months (95% CI = 1.7–11) for bilateral metastases ( p = 0.028). Primary RCC with positive expression of mTOR had higher mOS after metastasectomy than negative cases ( p < 0.001), NR at mean FU of 4.3 years versus mOS of 2 years (95% CI = 0.7–3.3), respectively. PD-L1 positivity on intra-tumor (TILs) and peri-tumor (RILs) infiltrating lymphocytes of metastases was related to higher OS, NR versus 2 years (95% CI = 1.2–2.7, p = 0.003), and NR versus 1.4 years (95% CI = 0.2–2.6, p = 0.012), respectively. The shorter was the surgical interval, the more probably the metastases had high c-MET expression (>70%) ( p = 0.007) and PD-L1 expression >10% on TILs ( p = 0.024). Conclusions: mTOR positivity on primary RCC could be a favorable prognostic factor to select patients for pulmonary metastasectomy. The positive impact of PD-L1 expression on immune cells is opposite to the well-known negative prognostic value of PD-L1 on tumor cells in RCC.

Renal cell carcinoma. A histopathological analysis of the pseudocapsule of tumour and paritumoral parenchyma

2019 ◽  
Vol 7 (1) ◽  
pp. 49-54
Author(s):  
M.Ya. Gaas ◽  
◽  
L.M. Rapoport ◽  
M.E. Enikeev ◽  
D.V. Enikeev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Histopathological Analysis

Clinical evaluation of 2-(18F) fluoro-2 deoxy-D-glucose PET/ CT in hereditary leiomyomatosis and renal cell carcinoma.

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 383-383 ◽  
Author(s):  
Brian Shuch ◽  
Kevin P. Asher ◽  
Clara Chen ◽  
Kelly Lin ◽  
Gennady Bratslavsky ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Kidney Cancer ◽  
Fdg Pet ◽  
Renal Cell ◽  
Aerobic Glycolysis ◽  
Renal Lesions ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Hereditary Leiomyomatosis

383 Background: 2-(18F) fluoro-2 deoxy-D-glucose (FDG) PET/CT is a useful tool in the staging of malignancies. In patients with kidney cancer, the role of FDG is limited in those with clear-cell histology and remains to be evaluated with other subtypes. Kidney cancer associated with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is characterized by a defect in the Krebs cycle rendering these tumors highly dependent on aerobic glycolysis (the ‘Warburg effect’) with high glucose uptake to fulfill their energy requirements; we hypothesized that FDG PET/CT may have excellent sensitivity for staging in this condition. Methods: We retrospectively reviewed patients with HLRCC kidney cancer that underwent FDG PET/CT in conjunction with anatomic imaging at our institution. The ability of FDG PET/CT to detect malignant lesions (defined using pathologic or radiologic criteria) was evaluated. Results: A total of 30 patients underwent 42 PET /CTs. Conventional imaging identified a total of 107 lesions. Both patient and lesion-based analyses were performed. A total of 90 lesions, including ten renal lesions, were classified as malignant. 76 of 80 extra-renal lesions were correctly identified as malignant by PET/CT (sensitivity, 95%, CI 88-98%). In contrast, only 4 of 10 renal lesions were correctly identified as malignant (sensitivity, 40%, CI 17-69%). 11 of 12 histologically confirmed extra-renal lesions were PET avid (sensitivity, 92%, CI-64-98%). 10 of 12 (83%) benign lesions associated with HLRCC including uterine/cutaneous leiomyomas and adrenal nodules were PET avid. In a patient based analysis, all 18 patients with extra-renal spread of kidney cancer were correctly identified (sensitivity 100%, CI 82-100%). Conclusions: FDG PET/CT is a highly sensitive diagnostic modality for identifying metastatic kidney cancer associated with HLRCC. Prospective studies evaluating the utility of PET/CT imaging to characterize response to systemic therapy are currently underway.

scholarly journals 1715: Enhancing Renal Lesions in Patients with Prior Normal Abdominal Imaging: Insight into the Natural History of Renal Cell Carcinoma

2006 ◽  
Vol 175 (4S) ◽  
pp. 551-551
Author(s):  
Paul L. Crispen ◽  
Aldiana Soljic ◽  
Richard E. Greenberg ◽  
David Y.T. Chen ◽  
Robert G. Uzzo
Keyword(s):  
Renal Cell Carcinoma ◽  
Natural History ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Abdominal Imaging ◽  
Renal Lesions ◽  
History Of ◽  
Insight Into

scholarly journals Histopathological analysis of T1 renal cell carcinoma: Does presentation matter?

2008 ◽  
Vol 24 (4) ◽  
pp. 504 ◽  
Author(s):  
Ganesh Gopalakrishnan ◽  
Gaurav Gupta ◽  
SamiranDas Adhikary ◽  
Santosh Kumar ◽  
NinanK Chacko ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Histopathological Analysis

scholarly journals Histopathological Spectrum of Nephrectomies - A 10 Year Descriptive Study from a Tertiary Care Center in South India

2020 ◽  
Vol 7 (47) ◽  
pp. 2752-2756
Author(s):  
Bhavya P. Mohan ◽  
Jaylakshmy Payippat Leelamma ◽  
Letha Vilasiniamma ◽  
Suresh Bhat
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Care Center ◽  
Tertiary Care ◽  
Age Distribution ◽  
Age Groups ◽  
Renal Diseases ◽  
Malignant Tumours ◽  
Neoplastic Lesions

BACKGROUND Nephrectomy is the standard surgical treatment of neoplastic and non-neoplastic lesions in the kidney and provides more insight into the detailed histopathology of renal lesions. We wanted to identify the age groups, gender distribution and different histopathological types and subtypes of non-neoplastic and neoplastic lesions in nephrectomy specimens over a period of ten years. METHODS A retrospective analysis was done over a period of ten years (January 2006 to December 2015). All nephrectomy specimens received in the Department of Pathology, Government Medical College, Kottayam were recorded from histopathology registers and analysed with regard to age, gender and histopathological types. RESULTS A total of 532 lesions was encountered in our analysis. Males (61.8 %) were affected more than females (38.2 %). Lesions were more on the left side (50.8 %) than right side (49.2 %). Non-neoplastic lesions (53 %) outnumbered neoplastic lesions (47 %). Inflammatory and obstructive causes constituted the majority (43.8 %) in non-neoplastic lesions and renal cell carcinoma was the commonest neoplasm (71.2 %). CONCLUSIONS There is a wide age distribution of renal diseases in the present study. Inflammatory and obstructive conditions constituted the most common indication for nephrectomy, followed by malignant tumours. KEYWORDS Renal Cell Carcinoma, Nephrectomy, Pyelonephritis, Simple Renal Cyst, Wilms Tumour

scholarly journals Von Hippel-Lindau Tumor; Radiographic Images

2017 ◽  
Vol 2 (1) ◽  
pp. 30
Author(s):  
Reza Bidaki ◽  
Azam Ghanei ◽  
Seyed Mehdi Hosseinizade ◽  
Mohammad Ebrahim Ghanei
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Cysts ◽  
Cell Renal Cell Carcinoma ◽  
Radiographic Images ◽  
Von Hippel Lindau ◽  
Malignant Lesions ◽  
Vhl Disease ◽  
Renal Computed Tomography

The patient is a 34-year-old patient with abdominal pain, gross hematuria with anxiety and worries about it from 5 months ago. The physician requested renal computed tomography (CT) without and then with contrast for rule out of renal stone. However, he found multiple lesions in kidneys. The laboratory tests were normal except hematuria. He was a candidate for surgery. The pathologist reported clear red cell renal cell carcinoma. He was referred to a radiologist for staging. Von Hippel – Lindau (VHL) disease is an inherited and rare disease that is characterized by a variety of benign and malignant lesions (1). It preval ence is 1 in 31,000 -53,000 (2,3). Previous studies shown 59 – 63% of patients have renal cysts and 24 - 45 % renal cell carcinoma (4), and in 75 % of cases ,the lesions are bilateral (4, 5). Involvement of pancreas includes simple cysts (50 – 91%), serous m icrocystic adenomas (12%) and adenocarcinoma (7%) (2, 4).

scholarly journals Incidence and Predictive Factors of Benign Renal Lesions in Korean Patients with Preoperative Imaging Diagnoses of Renal Cell Carcinoma

2011 ◽  
Vol 26 (3) ◽  
pp. 360 ◽  
Author(s):  
Seo Yong Park ◽  
Seong Soo Jeon ◽  
Seo Yeon Lee ◽  
Byong Chang Jeong ◽  
Seong Il Seo ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Predictive Factors ◽  
Renal Cell ◽  
Preoperative Imaging ◽  
Renal Lesions ◽  
Korean Patients
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