Preventive effects of two continuous and interval endurance exercise protocols on myocardial Galectin-3 gene expressions in male Wistar rats following cardiac infarction induction

2021 ◽  
Vol 14 (1) ◽  
pp. 73-84
Author(s):  
ahmad mohammadi moghaddam ◽  
vahid tadibi ◽  
naser behpoor ◽  
afshin nazari
Keyword(s):  
Endurance Exercise ◽  
Wistar Rats ◽  
Gene Expressions ◽  
Cardiac Infarction ◽  
Galectin 3 ◽  
Male Wistar Rats ◽  
Preventive Effects

scholarly journals The Preventive Effects of Cynara scolymus Leaf and Flower Extracts on Diethylnitrosamine/ Acetylaminoflourene Induced Nephrotoxicity in Male Wistar Rats

2020 ◽  
Vol 8 (s2) ◽  
Author(s):  
Lamiaa Nabil Bakry ◽  
Abeer Mohamed Abd El-Hameed ◽  
Sanaa Mahmoud Abd El-Twab ◽  
Osama Mohamed Ahmed ◽  
Adel Abel-Moneim
Keyword(s):  
Wistar Rats ◽  
Cynara Scolymus ◽  
Male Wistar Rats ◽  
Preventive Effects

Preventive Effects of Sinigrin Against the Memory Deterioration in the Pentylenetetrazole-Kindled Male Wistar Rats: Possible Modulation of NLRP3 Pathway

2021 ◽  
Author(s):  
Fatemeh Aghaie ◽  
Mojgan Rajabi ◽  
Amin Hosseini ◽  
Fatemeh Moradifar ◽  
Samaneh Koneshlou ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Male Wistar Rats ◽  
Memory Deterioration ◽  
Preventive Effects

scholarly journals The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-19 ◽  
Author(s):  
Osama M. Ahmed ◽  
Hanaa I. Fahim ◽  
Heba Y. Ahmed ◽  
Hessah Mohammed Al-Muzafar ◽  
Rasha R. Ahmed ◽  
...  
Keyword(s):  
Liver Injury ◽  
Wistar Rats ◽  
Orange Peel ◽  
Mechanisms Of Action ◽  
Navel Orange ◽  
Oral Gavage ◽  
Male Wistar Rats ◽  
Hydroethanolic Extract ◽  
Preventive Effects ◽  
Peel Extract

N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury. Thus, this study was designed to assess the preventive effects and to suggest the mechanisms of action of the navel orange peel hydroethanolic extract, naringin, and naringenin in APAP-induced hepatotoxicity in male Wistar rats. APAP was administered to male Wistar rats at a dose level of 0.5 g/kg body weight (b.w.) by oral gavage every other day for 4 weeks. APAP-administered rats were treated with the navel orange peel hydroethanolic extract (50 mg/kg b.w.), naringin (20 mg/kg b.w.), and naringenin (20 mg/kg b.w.) by oral gavage every other day during the same period of APAP administration. The treatments of APAP-administered rats with the peel extract, naringin, and naringenin produced a significant decrease in the elevated serum AST, ALT, ALP, LDH, and GGT activities as well as total bilirubin and TNF-αlevels while they induced a significant increase in the lowered serum albumin and IL-4 levels. The treatments also resulted in a significant decrease in the elevated liver lipid peroxidation and enhanced the liver GSH content and SOD, GST, and GPx activities as compared with APAP-administered control; the peel extract was the most potent in improving the liver LPO, GSH content, and GPx activity. In addition, the three treatments significantly downregulated the elevated hepatic proapoptotic mediators p53, Bax, and caspase-3 and significantly upregulated the suppressed antiapoptotic protein, Bcl-2, in APAP-administered rats. In association, the treatments markedly amended the APAP-induced liver histopathological deteriorations that include hepatocyte steatosis, cytoplasmic vacuolization, hydropic degeneration, and necrosis together with mononuclear leucocytic and fibroblastic inflammatory cells’ infiltration. In conclusion, the navel orange peel hydroethanolic extract, naringin, and naringenin may exert their hepatopreventive effects in APAP-administered ratsviaenhancement of the antioxidant defense system and suppression of inflammation and apoptosis.

Effects of resveratrol supplementation in male Wistar rats undergoing an endurance exercise and acute exercise training

2019 ◽  
Vol 27 (4) ◽  
pp. 257-264 ◽  
Author(s):  
Reza Vafaee ◽  
Hamid Soori ◽  
Mehdi Hedayati ◽  
Elaheh Ainy ◽  
Hamidreza Hatamabadi
Keyword(s):  
Exercise Training ◽  
Endurance Exercise ◽  
Wistar Rats ◽  
Acute Exercise ◽  
Male Wistar Rats

scholarly journals The Effect of Training Type on Hepatic Gene expressions of Apolipoprotein A‐I, and Apolipoprotein A‐II among Male Wistar Rats

2019 ◽  
Vol 27 (2) ◽  
pp. 30-40
Author(s):  
Bahman Hasanvand ◽  
Kobra Karami ◽  
YAGHOUB MEHRIALVAR ◽  
◽  
◽  
...  
Keyword(s):  
Wistar Rats ◽  
Gene Expressions ◽  
Apolipoprotein A ◽  
Male Wistar Rats

scholarly journals Fermented Grain Beverage Supplementation Following Exercise Promotes Glycogen Supercompensation in Rodent Skeletal Muscle and Liver

2017 ◽  
Vol 2 (1) ◽  
pp. 1 ◽  
Author(s):  
Tsubasa Shibaguchi ◽  
Rie Ishizawa ◽  
Atsushi Tsuji ◽  
Yuya Yamazaki ◽  
Keizo Matsui ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Endurance Exercise ◽  
Skeletal Muscles ◽  
Wistar Rats ◽  
Gastrocnemius Muscle ◽  
Glycogen Storage ◽  
Rat Skeletal Muscle ◽  
Rest Periods ◽  
Male Wistar Rats ◽  
Gastrocnemius Muscles

The purpose of this study was to investigate the effects of post-endurance exercise fermented grain beverage (FGB) supplementation on glycogen reaccumulation in rat skeletal muscle and liver. Twelve-hour fasted male Wistar rats, 10-week-old, performed five 30-min bouts of swimming separated by 5-min rest periods in order to deplete tissue glycogen storage. The rats were orally administrated either water, glucose, or FGB in 30, 60, 90, and 120 min after the exercise. Immediately and/or 240 min after the exercise, soleus and gastrocnemius muscles and liver were removed and analyzed. A large glycogen reaccumulation was observed in skeletal muscles and liver at 240 min after the exercise when either glucose or FGB were ingested. This response tended to be greater in FGB-treated than in glucose-treated animals, particularly in liver and gastrocnemius muscle. These results suggest that post-endurance exercise FGB supplementation enhances glycogen restoration in both skeletal muscle and liver.

scholarly journals Central Injection of Substance P Antagonizes the RF Amide-Related Peptide-3 Impacts on Hypothalamic KISS-1 and GnRH Gene Expressions in Male Wistar Rats

2018 ◽  
Vol 3 (3) ◽  
pp. 127-132
Author(s):  
Parastoo Rahdar ◽  
Homayoun Khazali
Keyword(s):  
Substance P ◽  
Receptor Antagonist ◽  
Wistar Rats ◽  
Target Genes ◽  
Male Rats ◽  
Gene Expressions ◽  
Related Peptide ◽  
Male Wistar Rats ◽  
Gonadotropin Inhibitory Hormone ◽  
Kndy Neurons

Background: Gonadotropin-inhibitory hormone and its mammalian orthologues (RFRP: RF amid related peptide) are known to inhibit the secretion of gonadotropins. In addition, substance P (SP) a member of tachykinin’s family is demonstrated that can increase the firing rate of kisspeptin/neurokinin B/dynorphin (KNDy) neurons and provokes the of secretion gonadotropins. In this experimental study we investigated the effects of co-administration of RFRP-3 and SP on the expression of KISS-1 and GnRH genes in male rats. Methods: forty-two mature Wistar rats were randomly allocated in 7 groups (n=6 in each group). Animals in each group intracerebroventricularly received either saline+DMSO, 1nmol SP, 5 nmol RFRP-3, 1nmol SP plus 5 nmol RFRP-3, 1 nmol SP plus10 nmol RF9 (RFRP-3 receptor antagonist), 1 nmol SP plus 1 nmol P234 (kisspeptin receptor antagonist) plus 5 nmol RFRP-3 or 1 nmol SP plus 5 nmol CP-96,345 (SP receptor antagonist) plus 5 nmol RFRP-3 in final volume of 3 µl. After two hours following injections hypothalamic samples were collected for evaluating the expression of target genes by real-time PCR technique. Results: Injections in SP and SP plus RF9 groups increase the expression of the both GnRH and KISS-1 genes (P<0.05). Injections in RFRP-3 group and SP plus RFRP-3 plus SP antagonist group significantly decrease the expression of both GnRH and KISS-1 genes (P<0.05). Injections of SP plus RFRP-3 group and SP plus RFRP-3 plus P234 group did not significantly change the expression of GnRH and KISS-1 genes. Conclusion: The results indicate that SP antagonizes the effects of RFRP-3 on the expression of Hypothalamic KISS-1 and GnRH genes.

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