ABOUT DEMENTIA

Dementia is a general term used to describe a loss of memory that keeps getting worse - or is 'progressive'. There can be many different causes, they will all involve loss of memory, but they have other symptoms which are different according to the cause. Dementia often starts off with just memory problems, but can also involve: difficulty planning and carrying out day-to-day tasks, difficulty communicating and changes in mood, judgement or personality. Aim of this article is to identify spread of dementia in 200 patients who have not been diagnosed before . Research was done in ONCO center of Adjara during 2014-2015 , involved 200 patients , female-130 , male-70, . For diagnosis of dementia we studied anamnesis, physical data, psychic and cognitive development of patient, family members were questioned often because of the difficulties patients had to explain symptoms they experienced. All patients had CT scan and evaluated bey Vavilov Method. Arterial Hypertension ,Discirculatory encephalopathy -171, Cancer-5 , Parkinson disease-10 , endocrine disorders-14 , family history of dementia -3 were noted in patients . From 200 patient examined 170 were diagnosed with dementia , Light dementia(10%). experienced memory deterioration Average quality dementia (55%) , During severe dementia (35%). Some risk factors for dementia, such as genetics and age . Cannot be changed. but researchers continue to explore the impact of other risk factors on brain health and prevention of dementia.

PSYCHOLOGICAL AND PEDAGOGICAL MEMORY SUPPORT OF THE ELDERLY AGE PEOPLE

The main problem of old age is memory loss. Memory deterioration usually occurs after 50 years, and by the age of 65 every second person complains of poor memory.

The role of epigenetic modifications in Alzheimer’s disease

Aging is the primary risk factor for various neurodegenerative diseases, including Alzheimer’s disease (AD), which is the most frequent form of Dementia. AD is progressive neurodegenerative disease with abnormal protein production, inflammation and memory deterioration. The main clinical manifestations of this illness are cognitive disturbance and memory deficit. Abnormal of beta-amyloid (Aβ), neurofibrillary tangles (NFTs) and tau deposition are the most common findings pathology in this disease. Recent studies indicate that epigenetic modifications strongly correlate in developing these pathology and disease progression. The hallmarks of epigenetic modifications are DNA (deoxyribonucleic acid) methylation, histone modifications, chromatin remodeling and ncRNA (non-coding ribonucleic acid) expressions. This review aims to explain the potential mechanisms of epigenetic modifications associate with this disease. The general conclusion of this review is that epigenetic modifications play an ultimate role in AD and there are potential biomarkers of AD and future novel treatment of AD based on epigenetics.

Subacute Sclerosing Panencephalitis with Subclinical Infection

Subacute Sclerosing Panencephalitis (SSPE) is a chronic complication of measles. It is a neurodegenerative disorder characterized by cognitive and memory deterioration, behaviour abnormalities, involuntary movements and repetitive myoclonic jerks and a steady motor decline. We report a case of a 7-year-old girl with subacute sclerosing panencephalitis presenting with myoclonic jerks, regression of motor milestones and speech. The child was not immunised for measles. Magnetic resonance imaging revealed multiple variable-sized ill-defined T2W and FLAIR hyperintense areas are seen involving the white matter of the bilateral fronto-parietal lobes. Electroencephalograph findings and CSF analysis confirmed the diagnosis of subacute sclerosing panencephalitis.

Dietary Diversity and Self-Reported Memory Deterioration in Chinese Adults: A Prospective Study

Objectives To investigate the association between dietary diversity and memory deterioration in Chinese adults aged 50 years or older. Methods This study was based on the China Health and Nutrition Survey, a longitudinal study initiated in 1989. Information on general characteristics, lifestyle behaviors, medical history, and dietary intake (by 3-day dietary recall and household food inventory) were collected in each survey round. In the survey 2015, participants were additionally asked “How is your memory?” (very good, good, OK, bad, or very bad) and “In the past twelve months, how has your memory changed?” (improved, stayed the same, or deteriorated). The dietary diversity score (DDS) was developed according to the Chinese Dietary Guidelines and was calculated based on the data collected in the survey 2011. The DDS included eight food groups (cereals and tubers, vegetables, fruits, meat, soybeans and nuts, eggs, aquatic products, and milk and dairy products). If a participant consumed any food from a certain food group in the past 24 hours, then he would get one point for that food group. Average daily DDS scores were calculated. Participants who had been diagnosed with apoplexy and those who were uncertain about their memory status were excluded. Multinomial Logistic regression models were conducted to investigate the association between DDS scores and self-reported memory changes, taking the participants whose memory stayed the same as the reference. In the multivariate analysis, covariates (age, gender, residential region, education, and alcohol consumption) were adjusted. Results Of the 4363 participants included in our analysis, the percentages of participants who thought their memory was OK, bad (bad or very bad), and good (good or very good) were 43.3%, 24.3%, and 32.4%, respectively. 47.3% of the participants reported memory deterioration in the past 12 months, and 1.4% reported memory improvement. The average value of DDS in participants was 4.09 ± 1.13. Multivariate analysis showed that higher DDS (OR = 0.82,95% CI = 0.77∼0.87, P < 0.001) was inversely associated with the risk of memory deterioration. No association between memory improvement and dietary diversity was observed. Conclusions Lower dietary diversity was associated with self-reported memory deterioration in Chinese adults. Funding Sources The authors received no financial support.