scholarly journals THE BENEFITS VS POTENTIAL SIDE EFFECTS OF POSTCHEMOEMBOLIZATION FOR HEPATOCELLULAR CARCINOMA

2021 ◽  
Vol 1 (1) ◽  
pp. 17-27
Author(s):  
C.A. Silosi ◽  
M.V. Boldeanu ◽  
A. Andritoiu ◽  
M. Cojocaru ◽  
L. Boldeanu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Diseases ◽  
Tumor Tissue ◽  
Advanced Disease ◽  
Chemotherapeutic Agents ◽  
Considerable Improvement ◽  
Chronic Liver Diseases ◽  
Common Cause ◽  
Ideal Group ◽  
The Ideal

It is known that, among chronic liver diseases, the most common cause of morbidity and/or mortality is hepatocellular carcinoma. Due to the fact that most patients are diagnosed with advanced disease, surgical resection is no longer possible. These patients constitute the ideal group for transarterial chemoembolization, which consists of the local infusion of a mixture of chemotherapeutic agents, which will cause the suppression of blood supply of the cancerous lesions, the induction of ischemia, followed by the necrosis of the tumor tissue, with a considerable improvement in the survival rate.

scholarly journals Micro-RNAs in hepatitis B virus-related chronic liver diseases and hepatocellular carcinoma

2018 ◽  
Vol 10 (9) ◽  
pp. 558-570 ◽  
Author(s):  
Evangelista Sagnelli ◽  
Nicoletta Potenza ◽  
Lorenzo Onorato ◽  
Caterina Sagnelli ◽  
Nicola Coppola ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Micro Rnas ◽  
B Virus

Identification of a new marker of hepatocellular carcinoma by serum protein profiling of patients with chronic liver diseases

Hepatology ◽  
2004 ◽  
Vol 41 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Valérie Paradis ◽  
Francoise Degos ◽  
Delphine Dargère ◽  
Nanou Pham ◽  
Jacques Belghiti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Protein ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Protein Profiling ◽  
Chronic Liver Diseases

scholarly journals Quantitative Analysis of Aldolase A mRNA in Liver Discriminates between Hepatocellular Carcinoma and Cirrhosis

2000 ◽  
Vol 46 (7) ◽  
pp. 901-906 ◽  
Author(s):  
Giuseppe Castaldo ◽  
Giuseppe Calcagno ◽  
Raffaella Sibillo ◽  
Rosario Cuomo ◽  
Gerardo Nardone ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Quantitative Analysis ◽  
Hepatitis C ◽  
Liver Tissue ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Liver Biopsies ◽  
Aldolase A

Abstract Background: Chronic liver diseases can progress to cirrhosis and to hepatocellular carcinoma. Timely and unequivocal recognition of the neoplastic evolution of cirrhosis is critical. To this aim, we used a noncompetitive reverse transcription-PCR procedure to analyze aldolase A mRNA in liver tissue from patients with chronic liver diseases at different stages. Methods: We studied 12 patients with hepatocellular carcinoma, 19 patients affected by chronic hepatitis C or cirrhosis, and 7 healthy controls. Aldolase A mRNA was reverse-transcribed to cDNA, which was then amplified by PCR. The amplified segments were “read” with a novel dot-blot procedure. A calibrator with the same sequence, synthesized in vitro using a T7 phage promoter, was processed at scalar dilutions in parallel to the target samples to generate a calibration curve and so quantify the target mRNA (detection limit, 0.03 amol; linearity spanning five orders of magnitude). Results: Aldolase A mRNA was ∼10-fold higher in liver biopsies from patients with hepatocellular carcinoma vs patients with chronic hepatitis C or cirrhosis, and healthy individuals. Furthermore, aldolase A mRNA concentrations were 1.2- to 21.3-fold higher in 12 liver biopsies compared with the paired surrounding cirrhotic tissue. Conclusions: The quantitative analysis of liver tissue aldolase A mRNA differentiates between nonneoplastic chronic liver diseases and hepatocellular carcinoma, which suggests that it has diagnostic potential.

New MR imaging criteria with a diffusion-weighted sequence for the diagnosis of hepatocellular carcinoma in chronic liver diseases

2011 ◽  
Vol 55 (1) ◽  
pp. 126-132 ◽  
Author(s):  
Gilles Piana ◽  
Ludovic Trinquart ◽  
Nawel Meskine ◽  
Vincent Barrau ◽  
Bernard Van Beers ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Weighted Sequence ◽  
Diffusion Weighted
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