scholarly journals The Incidental prostatic adenocarcinoma and transitional cell carcinoma involvement of the prostate gland in patients undergoing radical cystoprostatectomy for bladder cancer treatment in Rajavithi Hospital

2021 ◽  
Vol 42 (2) ◽  
pp. 103-109
Author(s):  
Weerawut Promwattanapan ◽  
◽  
Nattapong Wongwattanasatien ◽  
Keyword(s):  
Bladder Cancer ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Prostate Gland ◽  
Transitional Cell ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Prostatic Adenocarcinoma ◽  
Pathological Findings ◽  
Radical Cystoprostatectomy

Objective: To determine the incidence of incidental prostatic adenocarcinoma and transitional cell carcinoma (TCC) involvement of the prostate gland in patients undergoing radical cystoprostatectomy in Rajavithi Hospital, Secondly, to assess the possible influence of the patient factors and bladder cancer on the pathological findings of the prostate gland. Materials and Methods: We retrospectively reviewed 169 male patients who had undergone radical cystoprostatectomy for bladder cancer between April 2013 and August 2019. Pathologic findings of the prostate gland and urothelial cancer in the prostate gland were catalogued. Information including age, body mass index (BMI), underlying disease, glomerular filtration rate (GFR), pathologic stage, and grade was collected and analyzed to determine any correlations. Results: Incidental prostatic adenocarcinoma and TCC involvement of the prostate gland were found in 15 patients (8.9%) and 29 patients (17.2%), respectively. There were no correlations between patient demographics and pathological findings of the prostate gland. Conclusion: Although the incidence of incidental prostatic adenocarcinoma and TCC involvement of the prostate gland in our research is low, the screening of every candidate for prostate sparing cystectomy with a digital rectal examination, prostate-specific antigen, and transurethral biopsy of the prostatic urethra and bladder neck prior to surgery are recommended.

scholarly journals Ureteric stricture: an unusual presentation of metastatic prostate adenocarcinoma

2012 ◽  
Vol 94 (7) ◽  
pp. e6-e7 ◽  
Author(s):  
S Jallad ◽  
R Turo ◽  
M Kimuli ◽  
J Smith ◽  
S Jain
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Metastatic Lesion ◽  
Prostate Adenocarcinoma ◽  
Prostatic Adenocarcinoma ◽  
Initial Examination ◽  
Ureteric Stricture

We describe an unusual case of a prostatic adenocarcinoma presenting with a ureteric stricture secondary to a discrete metastatic lesion. A 76-year-old man presented with a short history of right loin pain. Initial examination was unremarkable, digital rectal examination was normal and prostate specific antigen was within normal range. Computed tomography showed right hydronephrosis and a distal ureteric stricture. A distal ureteric transitional cell carcinoma was thought to be most likely. A nephroureterectomy was carried out and histology revealed a skipped lesion of a metastatic prostate adenocarcinoma. Metastatic lesions to the ureters due to prostate cancer are rare. It was believed to be secondary to a transitional cell carcinoma as there was no evidence initially to suggest prostatic disease as the cause. A prostatic adenocarcinoma should be considered in the differential diagnosis of any lesions in the ureter believed to have a malignant origin.

scholarly journals Adenocarcinoma in Ectopic Prostatic Tissue at Dome of Bladder: A Case Report of a Patient With Urothelial Carcinoma of the Bladder and Adenocarcinoma of the Prostate

2010 ◽  
Vol 134 (9) ◽  
pp. 1271-1275 ◽  
Author(s):  
Jerad M. Gardner ◽  
Hema Khurana ◽  
Fredrick S. Leach ◽  
Alberto G. Ayala ◽  
Jim Zhai ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Prostate Gland ◽  
Transitional Cell ◽  
Digital Rectal Examination ◽  
Prostatic Adenocarcinoma ◽  
Prostatic Tissue ◽  
Low Grade ◽  
Bladder Dome ◽  
First Case

Abstract We report a case of ectopic prostate tissue with an associated prostatic adenocarcinoma occurring in the dome of the urinary bladder. A 62-year-old man presented with a 4-month history of persistent microscopic hematuria following a urinary tract infection. Other complaints included frequent urination, but there was neither dysuria nor gross hematuria. Digital rectal examination revealed a smooth prostate of normal size. Cystoscopic examination revealed a sessile lesion of the anterior bladder neck and multiple smaller papillary lesions throughout the bladder. Following a transurethral resection of the bladder tumor with a diagnosis of muscle-invasive transitional cell carcinoma grade 3, a radical cystoprostatectomy was performed. The diagnosis of transitional cell carcinoma was confirmed, but in addition, a different lesion was also incidentally found in the dome of the bladder. This incidental lesion showed a prostatic adenocarcinoma arising from ectopic prostatic tissue within the bladder submucosa. The prostate also showed prostatic adenocarcinoma, but this was minimal, low grade, and confined to the prostate gland, and thus it was felt to be unlikely to have metastasized to the bladder dome. Adenocarcinoma arising in ectopic prostatic tissue is a rare finding and to our knowledge only 1 case has been previously described, occurring in the soft tissue adjacent to the prostate. We report the first case of adenocarcinoma arising in ectopic prostatic tissue within the bladder.

DOES PROSTATE TRANSITIONAL CELL CARCINOMA PRECLUDE ORTHOTOPIC BLADDER RECONSTRUCTION AFTER RADICAL CYSTOPROSTATECTOMY FOR BLADDER CANCER?

1997 ◽  
Vol 158 (6) ◽  
pp. 2123-2126 ◽  
Author(s):  
Christophe E. Iselin ◽  
Cary N. Robertson ◽  
George D. Webster ◽  
Johannes Vieweg ◽  
David F. Paulson
Keyword(s):  
Bladder Cancer ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Radical Cystoprostatectomy ◽  
Bladder Reconstruction

Unsuspected Prostatic Adenocarcinoma in Patients Who Have Undergone Radical Cystoprostatectomy for Transitional Cell Carcinoma of The Bladder

1988 ◽  
Vol 139 (6) ◽  
pp. 1214-1216 ◽  
Author(s):  
Thomas Rand Pritchett ◽  
Jose Moreno ◽  
Nancy E. Warner ◽  
Gary Lieskovsky ◽  
Peter W. Nichols ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Prostatic Adenocarcinoma ◽  
Radical Cystoprostatectomy ◽  
Carcinoma Of The Bladder

405: Previous History of Bladder Cancer is an Independent Prognostic Factor for Upper Tract Transitional Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 135-135
Author(s):  
Eiji Kikuchi ◽  
Akira Miyajima ◽  
Ken Nakagawa ◽  
Mototsugu Oya ◽  
Takashi Ohigashi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Factor ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Previous History ◽  
Independent Prognostic Factor ◽  
Upper Tract ◽  
History Of

1374: The Sensitivity of Transurethral Biopsy for Detecting Prostatic Involvement by Transitional Cell Carcinoma in Patients Undergoing Radical Cystoprostatectomy

2005 ◽  
Vol 173 (4S) ◽  
pp. 373-373 ◽  
Author(s):  
Steven S. Shen ◽  
Shilpa Lamba ◽  
Gilad E. Amiel ◽  
Luan D. Truong ◽  
Thomas M. Wheeler ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Radical Cystoprostatectomy

scholarly journals Paraneoplastic production of heparin-like anticoagulant in a patient with metastatic transitional cell carcinoma

2013 ◽  
Vol 3 (5) ◽  
pp. 61 ◽  
Author(s):  
Kelly N. Fahl ◽  
Stephen A. Poon ◽  
Ketan K. Badani ◽  
Mitchell C. Benson
Keyword(s):  
Bladder Cancer ◽  
Breast Carcinoma ◽  
Liver Failure ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hematological Malignancies ◽  
Transitional Cell ◽  
Carcinoma Breast ◽  
Severe Coagulopathy

It has been reported that patients with bladder cancer have widelyvarying paraneoplastic consequences, including metabolic, dermatologic,myopathic and neurologic disturbances. We report a case of a52-year-old man with advanced transitional cell carcinoma and livermetastases, who developed a severe coagulopathy following roboticradical cystoprostatectomy due to circulating heparin-like substancesprior to onset of liver failure. Heparin-like anticoagulant production isa rare paraneoplastic effect documented in concert with transitionalcell carcinoma, breast carcinoma and hematological malignancies.

Repeated Intravesical Instillations of an Adenoviral Vector in Patients With Locally Advanced Bladder Cancer: A Phase I Study of p53 Gene Therapy

2003 ◽  
Vol 21 (12) ◽  
pp. 2247-2253 ◽  
Author(s):  
Lance C. Pagliaro ◽  
Afsaneh Keyhani ◽  
Dallas Williams ◽  
Denise Woods ◽  
Baoshun Liu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bladder Cancer ◽  
Gene Transfer ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Locally Advanced ◽  
Transitional Cell ◽  
P53 Gene ◽  
Advanced Bladder Cancer ◽  
Intravesical Instillations

Purpose: We investigated the feasibility, safety, and biologic activity of adenovirus-mediated p53 gene transfer in patients with locally advanced bladder cancer. Patients and Methods: Patients with measurable, locally advanced transitional-cell carcinoma of the bladder who were not candidates for cystectomy were eligible. On a 28-day cycle, intravesical instillations of INGN 201 (Ad5CMV-p53) were administered on days 1 and 4 at three dose levels (1010 particles to 1012 particles) or on either 4 or 8 consecutive days at a single dose level (1012 particles). Results: Thirteen patients received a total of 22 courses without dose-limiting toxicity. Specific transgene expression was detected by reverse transcriptase polymerase chain reaction in bladder biopsy tissue from two of seven assessable patients. There were no changes in p53, p21waf1/cip1, or bax protein levels in bladder epithelium evident from immunohistochemical analysis of 11 assessable patients. Outpatient administration of multiple courses was feasible and well tolerated. A patient with advanced superficial bladder cancer showed evidence of tumor response. Conclusion: Intravesical instillation of Ad5CMV-p53 is safe, feasible, and biologically active when administered in multiple doses to patients with bladder cancer. Observations from this study indicate that this treatment has an antitumor effect in superficial transitional-cell carcinoma. Improvements in the efficiency of gene transfer and the levels of gene expression are required to develop more effective gene therapy for bladder cancer.

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