scholarly journals Mesenchymal Stem Cell-Based Therapy For Advanced Colorectal Cancer: Potential Mechanisms Of Therapy And Associated Risks

2021 ◽  
Vol 2 (2) ◽  
pp. 1
Author(s):  
Annie Hilland ◽  
Vincent S Gallicchio
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Advanced Colorectal Cancer ◽  
Cell Based Therapy

scholarly journals The Achievements and Challenges of Mesenchymal Stem Cell-Based Therapy in Inflammatory Bowel Disease and Its Associated Colorectal Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-18 ◽  
Author(s):  
Dickson Kofi Wiredu Ocansey ◽  
Wei Qiu ◽  
Jingyan Wang ◽  
Yongmin Yan ◽  
Hui Qian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bowel Disease ◽  
Experimental Models ◽  
Trophic Factors ◽  
Cell Based Therapy ◽  
Inflammatory Bowel ◽  
Tumor Growth And Metastasis

Approximately 18.1×106 new cases of cancer were recorded globally in 2018, out of which 9.6 million died. It is known that people who have Inflammatory Bowel Disease (IBD) turn to be prone to increased risks of developing colorectal cancer (CRC), which has global incident and mortality rates of 10.2% and 9.2%, respectively. Over the years, conventional treatments of IBD and its associated CRC have been noted to provide scarce desired results and often with severe complications. The introduction of biological agents as a better therapeutic approach has witnessed a great deal of success in both experimental and clinical models. With regard to mesenchymal stem cell (MSC) therapy, the ability of these cells to actively proliferate, undergo plastic differentiation, trigger strong immune regulation, exhibit low immunogenicity, and express abundant trophic factors has ensured their success in regenerative medicine and immune intervention therapies. Notwithstanding, MSC-based therapy is still confronted with some challenges including the likelihood of promoting tumor growth and metastasis, and possible overestimated therapeutic potentials. We review the success story of MSC-based therapy in IBD and its associated CRC as documented in experimental models and clinical trials, examining some of the challenges encountered and possible ways forward to producing an optimum MSC therapeutic imparts.

Mesenchymal stem cell-based therapy for nonhealing wounds: today and tomorrow

2015 ◽  
Vol 23 (4) ◽  
pp. 465-482 ◽  
Author(s):  
Meirong Li ◽  
Yali Zhao ◽  
Haojie Hao ◽  
Weidong Han ◽  
Xiaobing Fu
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Based Therapy

scholarly journals Mesenchymal Stem Cell-Based Therapy

2012 ◽  
Vol 10 (1) ◽  
pp. 77-89 ◽  
Author(s):  
Vaibhav Mundra ◽  
Ivan C. Gerling ◽  
Ram I. Mahato
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Based Therapy

scholarly journals Mesenchymal Stem Cell-Based Therapy Improves Lower Limb Movement After Spinal Cord Ischemia in Rats

2018 ◽  
Vol 105 (5) ◽  
pp. 1523-1530 ◽  
Author(s):  
Shinya Takahashi ◽  
Kei Nakagawa ◽  
Mayumi Tomiyasu ◽  
Ayumu Nakashima ◽  
Keijiro Katayama ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Lower Limb ◽  
Spinal Cord Ischemia ◽  
Limb Movement ◽  
Cell Based Therapy ◽  
Lower Limb Movement

scholarly journals Challenges for Mesenchymal Stem Cell-Based Therapy for COVID-19

2020 ◽  
Vol Volume 14 ◽  
pp. 3995-4001 ◽  
Author(s):  
Chenghai Li ◽  
Hua Zhao ◽  
Bin Wang
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Based Therapy

Molecular and Cellular Mechanisms Involved in Mesenchymal Stem Cell-Based Therapy of Inflammatory Bowel Diseases

2017 ◽  
Vol 14 (2) ◽  
pp. 153-165 ◽  
Author(s):  
Bojana Simovic Markovic ◽  
Tatjana Kanjevac ◽  
C. Randall Harrell ◽  
Marina Gazdic ◽  
Crissy Fellabaum ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Inflammatory Bowel Diseases ◽  
Cellular Mechanisms ◽  
Cell Based Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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