Molecular and Cellular Mechanisms Involved in Mesenchymal Stem Cell-Based Therapy of Inflammatory Bowel Diseases

2017 ◽  
Vol 14 (2) ◽  
pp. 153-165 ◽  
Author(s):  
Bojana Simovic Markovic ◽  
Tatjana Kanjevac ◽  
C. Randall Harrell ◽  
Marina Gazdic ◽  
Crissy Fellabaum ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Inflammatory Bowel Diseases ◽  
Cellular Mechanisms ◽  
Cell Based Therapy ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals The Achievements and Challenges of Mesenchymal Stem Cell-Based Therapy in Inflammatory Bowel Disease and Its Associated Colorectal Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-18 ◽  
Author(s):  
Dickson Kofi Wiredu Ocansey ◽  
Wei Qiu ◽  
Jingyan Wang ◽  
Yongmin Yan ◽  
Hui Qian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bowel Disease ◽  
Experimental Models ◽  
Trophic Factors ◽  
Cell Based Therapy ◽  
Inflammatory Bowel ◽  
Tumor Growth And Metastasis

Approximately 18.1×106 new cases of cancer were recorded globally in 2018, out of which 9.6 million died. It is known that people who have Inflammatory Bowel Disease (IBD) turn to be prone to increased risks of developing colorectal cancer (CRC), which has global incident and mortality rates of 10.2% and 9.2%, respectively. Over the years, conventional treatments of IBD and its associated CRC have been noted to provide scarce desired results and often with severe complications. The introduction of biological agents as a better therapeutic approach has witnessed a great deal of success in both experimental and clinical models. With regard to mesenchymal stem cell (MSC) therapy, the ability of these cells to actively proliferate, undergo plastic differentiation, trigger strong immune regulation, exhibit low immunogenicity, and express abundant trophic factors has ensured their success in regenerative medicine and immune intervention therapies. Notwithstanding, MSC-based therapy is still confronted with some challenges including the likelihood of promoting tumor growth and metastasis, and possible overestimated therapeutic potentials. We review the success story of MSC-based therapy in IBD and its associated CRC as documented in experimental models and clinical trials, examining some of the challenges encountered and possible ways forward to producing an optimum MSC therapeutic imparts.

Steroid Therapy for Inflammatory Bowel Diseases (IBD) Reduces Intestinal Stem Cell (ISC) Activation and Proliferation Required for Mucosal Restitution

2017 ◽  
Vol 152 (5) ◽  
pp. S1001
Author(s):  
Evan B. Lynch ◽  
Tatiana Goretsky ◽  
Emily M. Bradford ◽  
Tianyan Gao ◽  
Terrence Barrett
Keyword(s):  
Stem Cell ◽  
Steroid Therapy ◽  
Inflammatory Bowel Diseases ◽  
Intestinal Stem Cell ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Incidence rates and disease course of pediatric inflammatory bowel diseases in western Hungary between 1977 – 2011

2014 ◽  
Vol 52 (05) ◽  
Author(s):  
B Lovász ◽  
L Lakatos ◽  
Á Horváth ◽  
T Pandúr ◽  
Z Erdélyi ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Incidence Rates ◽  
Disease Course ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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