Primary Prostatic Leiomyosarcoma With Pulmonary Metastases in a Dog

2010 ◽  
Vol 46 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Barbara Bacci ◽  
Massimo Vignoli ◽  
Federica Rossi ◽  
Francesco Gallorini ◽  
Rossella Terragni ◽  
...  
Keyword(s):  
Immunohistochemical Staining ◽  
Pulmonary Metastases ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Computed Tomography Scan ◽  
Intact Male ◽  
Spindle Cells ◽  
S 100 ◽  
Total Body ◽  
Tomography Scan

A 6-year-old, intact male Jack Russell terrier was diagnosed with a mass in the caudal abdomen, and ultrasound revealed a large prostatic mass. A total-body computed tomography scan was performed for staging, and lung nodules were detected. Histological examination showed a proliferation of spindle cells arranged in interlacing fascicles. Immunohistochemical staining revealed cells were cytokeratin negative and immunoreactive for vimentin and α-smooth muscle actin; cells stained with desmin and S-100 were negative. A diagnosis of primary prostatic leiomyosarcoma with pulmonary metastases was made. This is one of the rare cases of primary prostatic mesenchymal tumor in the canine species.

Leiomyomatous hamartoma of the incisive papilla

2002 ◽  
Vol 25 (2) ◽  
pp. 157-159 ◽  
Author(s):  
Luciana Corrêa ◽  
Mônica Lotufo ◽  
Marília Trierveiler Martins ◽  
Norberto Sugaya ◽  
Suzana Cantanhede Orsini Machado de Sousa
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Muscle Cells ◽  
Histological Diagnosis ◽  
Muscle Actin ◽  
Histological Findings ◽  
Spindle Cells ◽  
Congenital Epulis

A case of unusual hamartoma in a six-year-old otherwise healthy Brazilian girl is reported, with emphasis on histological and immunohistochemical features. A mass observed in the incisive papilla was detected whose appearance was similar to congenital epulis or fibroma. Histological findings showed interlacing fascicles of large spindle cells resembling smooth muscle cells. Immunohistochemical staining for desmin and for smooth-muscle actin was positive. The histological diagnosis was leiomyomatous hamartoma, based on clinical and microscopic observations.

Immunohistochemical Staining Characteristics of Canine Gastrointestinal Stromal Tumors

1997 ◽  
Vol 34 (4) ◽  
pp. 303-311 ◽  
Author(s):  
R. G. LaRock ◽  
P. E. Ginn
Keyword(s):  
Smooth Muscle ◽  
Small Intestine ◽  
Immunohistochemical Staining ◽  
Gastrointestinal Stromal Tumors ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Stromal Tumors ◽  
S 100 ◽  
Microscopic Features ◽  
Microscopic Diagnosis

Sections from 35 formalin-fixed, paraffin-embedded, canine gastrointestinal stromal tumors consisting of 14 leiomyomas (five stomach, three small intestine, two colon, four rectum), 18 leiomyosarcomas (one stomach, five small intestine, nine cecum, three rectum), two undifferentiated sarcomas (two stomach), and one neurofibrosarcoma (small intestine) were examined for the expression of vimentin, S-100 protein, α-smooth muscle actin, and desmin via immunoperoxidase methodology using an avidin-biotin complex technique. The leiomyomas were 4/14 (29%) vimentin-positive, 3/14 (21%) S-100 protein-positive, 10/14 (71%) α-smooth muscle actin-positive and 13/14 (93%) desmin-positive. Leiomyosarcomas were 18/18 (100%) vimentin-positive, 11/18 (61%) S-100 protein-positive, 9/18 (50%) α-smooth muscle actin-positive, and 15/18 (83%) desmin-positive. The undifferentiated sarcomas were 2/2 (100%) vimentin-positive, 2/2 (100%) S-100 protein-positive, 1/2 (50%) α-smooth muscle actin-positive, and 0/2 (0%) desmin-positive. The neurofibrosarcoma was vimentin and S-100 protein-positive and α-smooth muscle actin- and desmin-negative. Thirty-one of thirty-five (89%) of all neoplasms demonstrated reactivity for either desmin and/or α-smooth muscle actin. S-100 protein reactivity occurred in 17/35 (49%) of all specimens. Lack of desmin and α-smooth muscle actin reactivity occurred in 4/35 (11%) of all specimens, all of which were vimentin-positive. The immunohistochemical results indicate that the majority of canine gastrointestinal stromal tumors (GIST) with light microscopic features of smooth muscle cells have immunohistochemical staining patterns supporting smooth muscle differentiation. Vimentin reactivity correlated with a light microscopic diagnosis of malignancy. The lack of smooth muscle cell markers in some tumors and the high percentage of cases positive for S-100 protein may suggest a more complex histogenesis or differentiation for subgroups of these tumors.

Angiomyofibroblastoma of the Male Inguinal Region

2000 ◽  
Vol 124 (11) ◽  
pp. 1679-1681
Author(s):  
Makoto Ito ◽  
Hideyuki Yamaoka ◽  
Kenji Sano ◽  
Masao Hotchi
Keyword(s):  
Smooth Muscle ◽  
Blood Vessels ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Inguinal Region ◽  
Fibrous Capsule ◽  
Muscle Actin ◽  
Spindle Cells ◽  
Pleomorphic Cells

Abstract We present a case of benign angiomyxoid tumor arising in the inguinal region of a 27-year-old man. The tumor was a gelatinous mass completely encapsulated by a thin fibrous capsule with no hemorrhage or necrosis. Histologically, a proliferation of spindle cells as well as occasional pleomorphic cells was observed within the myxofibrous stroma, intermingled with abundant capillary-sized blood vessels. Immunohistochemical staining of the tumor demonstrated spindle, oval, and pleomorphic cells equally positive for vimentin, desmin, and CD34, but not for α-smooth muscle actin. Based on these histologic and immunophenotypic features, we conclude that this angiomyxoid tumor of the male inguinal region is indistinguishable from the female angiomyofibroblastoma of the pelvic and perineal regions.

Primary leiomyoma of the thyroid gland

2003 ◽  
Vol 117 (10) ◽  
pp. 832-834 ◽  
Author(s):  
Suna Erkiliç ◽  
Ahmet Erkiliç ◽  
Yildirim A. Bayazit
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Subtotal Thyroidectomy ◽  
Muscle Actin ◽  
Thyroid Lobe ◽  
Surgical Specimen ◽  
Spindle Cells ◽  
The Right

Primary thyroid leiomyomas are rare, and only four cases have been reported to date. This is a report of an additional case of primary thyroid leiomyoma in a 40-year-old male who was admitted with a painless swelling in the right thyroid lobe and underwent subtotal thyroidectomy. The surgical specimen showed a well-circumscribed, greyish-white solid nodule. Histologically, the tumour was composed of spindle cells with blunt-ended nuclei that were arranged with short intersecting bundles.Immunohistochemical staining revealed reactivity with smooth muscle actin, vimentin and desmin. Histopathologic and immunohistochemical assessments produced the diagnosis of thyroid leiomyoma.Although primary thyroid leiomyoma is rare, it should be considered in the differential diagnosis of a cold thyroid nodule.

scholarly journals Inflammatory fibroid polyp: an immunohistochemical study

2004 ◽  
Vol 41 (2) ◽  
pp. 104-107 ◽  
Author(s):  
Gilda da Cunha Santos ◽  
Venâncio A.F. Alves ◽  
Alda Wakamatsu ◽  
Sérgio Zucoloto
Keyword(s):  
Smooth Muscle ◽  
Factor Viii ◽  
Immunohistochemical Study ◽  
Smooth Muscle Actin ◽  
Positive Staining ◽  
Muscle Actin ◽  
Inflammatory Fibroid Polyp ◽  
Spindle Cells ◽  
S 100 ◽  
Fibroid Polyp

BACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.

scholarly journals Renal myxoma: An unforeseen diagnosis

2020 ◽  
Vol 92 (3) ◽  
Author(s):  
Rui Miguel Bernardino ◽  
Luis Severo ◽  
Luis Mascarenhas Lemos ◽  
Luis Campos Pinheiro
Keyword(s):  
Smooth Muscle ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Renal Involvement ◽  
Bladder Tumour ◽  
Muscle Actin ◽  
Spindle Cells ◽  
Rare Tumours ◽  
Myxoid Matrix ◽  
Recurrent Hematuria

Myxomas are rare tumours that can be found in many anatomical locations. There are only 17 cases of renal involvement documented. Our case is an 85 year-old man followed in our consultation with recurrent hematuria after a transurethral resection of a bladder tumour. Evaluation with CT showed a solid lesion with 23 x 18 mm partially obliterating the left inferior calyx. The patient underwent a left nephroureterectomy. Microscopic examination showed a mass within renal parenchyma adjacent to the renal pelvis composed of plump mildly atypical spindle cells distributed in a copious myxoid matrix. Immunohistochemical staining for Vimentine, Pankeratin (AE1/AE3-), CD34, CD31 and smooth muscle actin were negative. With these histopathological and immunohistochemical findings, the case was diagnosed as renal myxoma.

Renal Myopericytoma: Case Report and Review of Literature

2012 ◽  
Vol 136 (5) ◽  
pp. 563-566 ◽  
Author(s):  
Sadhna Dhingra ◽  
Alberto Ayala ◽  
Hong Chai ◽  
Vanessa Moreno ◽  
Bihong Zhao
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Renal Mass ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Review Of Literature ◽  
Computed Tomography Scan ◽  
Muscle Myosin ◽  
Cd34 Expression ◽  
Tomography Scan

Myopericytoma arising in the visceral organs is rare and only 1 case of renal myopericytoma has been reported in the literature to date. We report the second case of myopericytoma arising in the kidney in a 40-year-old Hispanic woman who presented with pain on the left side of the abdomen and frequent urination. Abdominal computed tomography scan showed an exophytic left-sided renal mass. Partial nephrectomy was performed. The patient remains free of disease at 24 months after diagnosis. Our case is histologically distinct from the previously described case as it lacks the “hemangiopericytic/glomangiopericytoma” pattern. The tumor in our case showed the characteristic pattern of myopericytoma and an additional glomus tumorlike pattern. The tumor cells showed diffuse reactivity for vimentin, smooth muscle actin, smooth muscle myosin heavy chain, and muscle-specific actin in both morphologic patterns and strong diffuse CD34 expression in glomus tumorlike focus. This case report adds to the morphologic heterogeneity of myopericytomas.

scholarly journals Preoperatively diagnosed gastric collision tumor with mixed adenocarcinoma and gastrointestinal stromal tumor: a case report and literature review

2021 ◽  
Author(s):  
Kunihiko Matsuno ◽  
Yoshikazu Kanazawa ◽  
Daisuke Kakinuma ◽  
Nobutoshi Hagiwara ◽  
Fumihiko Ando ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Distal Gastrectomy ◽  
Submucosal Tumor ◽  
Smooth Muscle Actin ◽  
Collision Tumor ◽  
Stromal Tumor ◽  
Lower Body ◽  
Muscle Actin ◽  
First Case ◽  
S 100

AbstractReports of gastric collision tumors, comprising adenocarcinoma and gastrointestinal stromal tumor, are extremely rare. Here, we report the case of a 68-year-old male who was diagnosed with a lower-body, moderately differentiated, tubular-type adenocarcinoma and submucosal tumor and underwent an elective D2 distal gastrectomy. The tumor cells of the gastrointestinal stromal tumor were positive for H-caldesmon and CD117, weakly positive for smooth muscle actin and DOG-1, and negative for desmin, S-100 protein, CD31, and AE1/AE3. The tumor had grown into a mixed form of adenocarcinoma and gastrointestinal stromal tumor. Thus, we report the first case of a preoperatively diagnosed collision tumor in the stomach consisting of adenocarcinoma and gastrointestinal stromal tumor.

Mammary-type Myofibroblastoma with Leiomyomatous Differentiation: A Rare Variant with Potential Pitfalls

2021 ◽  
pp. 106689692110313
Author(s):  
Alexander M. Strait ◽  
Julia A. Bridge ◽  
Anthony J. Iafrate ◽  
Marilyn M. Li ◽  
Feng Xu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Transcriptome Sequencing ◽  
Smooth Muscle Actin ◽  
The Body ◽  
Muscle Actin ◽  
Mature Adipose Tissue ◽  
Spindle Cells ◽  
Whole Transcriptome Sequencing ◽  
Whole Transcriptome

Myofibroblastoma is a rare, benign stromal tumor with a diverse morphologic spectrum. Mammary-type myofibroblastoma (MTMF) is the extra-mammary counterpart of this neoplasm and its occurrence throughout the body has become increasingly recognized. Similar morphologic variations of MTMF have now been described which mirror those seen in the breast. We describe a case of intra-abdominal MTMF composed of short fascicles of eosinophilic spindle cells admixed with mature adipose tissue. The spindle cells stained diffusely positive for CD34, desmin, smooth muscle actin, and h-caldesmon by immunohistochemistry. Concurrent loss of RB1 (13q14) and 13q34 loci were confirmed by fluorescence in situ hybridization whereas anchored multiplex PCR and whole transcriptome sequencing did not reveal any pathognomonic fusions suggesting an alternative diagnosis. To the best of our knowledge this is the first documented case of leiomyomatous variant of MTMF.

Benign Myoepithelioma of the Lung

2001 ◽  
Vol 125 (11) ◽  
pp. 1494-1496
Author(s):  
Ravindra Veeramachaneni ◽  
Janis Gulick ◽  
Ari O. Halldorsson ◽  
Thanh T. Van ◽  
Ping L. Zhang ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Emission Tomography ◽  
Muscle Actin ◽  
Computed Tomographic ◽  
Spindle Cells ◽  
Positron Emission ◽  
Computed Tomographic Scan ◽  
Wedge Biopsy

Abstract This report describes a benign myoepithelioma of the lung that occurred in a 60-year-old woman. The patient had experienced hoarseness for 6 weeks, and a computed tomographic scan showed a nodule of approximately 2 cm in diameter at the peripheral portion of her right upper lung. Positron emission tomography showed no uptake of F-18 fluorodeoxyglucose in the nodule. Wedge biopsy of the lesion showed benign spindle cells arranged in a whorled pattern. The cells were positive for both cytokeratin and smooth muscle actin, which corresponded to the presence of tonofilaments and myofilaments that were identified ultrastructurally. The features of the present case of benign myoepithelioma that differ from features of previously reported benign and malignant cases of myoepithelioma in the lung are discussed in the report.

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