Unfavorable influence of anesthesia and surgery on Doberman pinschers with occult cardiomyopathy

1996 ◽  
Vol 32 (1) ◽  
pp. 57-62 ◽  
Author(s):  
CA Calvert ◽  
GJ Jacobs ◽  
CW Pickus
Keyword(s):  
Heart Failure ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Heart Rhythm ◽  
Left Ventricular ◽  
Ventricular Tachyarrhythmias ◽  
Myocardial Failure ◽  
Doberman Pinschers ◽  
Life Threatening ◽  
Over Time

Exacerbation of heart rhythm disturbances or deterioration of left-ventricular function occurred in six Doberman pinschers with occult cardiomyopathy following anesthesia and surgery. These abnormalities improved over time in surviving dogs, supporting a causal relationship between anesthesia/surgery and exacerbation. Moderate myocardial failure and ventricular tachyarrhythmias of variable severity existed prior to anesthesia and surgery in each dog. The incidence of these adverse effects is uncertain but probably significant. Exacerbation of arrhythmias may be life-threatening or lethal. Embarrassment of left-ventricular function may be inapparent or, if function already is marginal, may precipitate congestive heart failure.

scholarly journals ACE Inhibition Modulates Myeloid Hematopoiesis after Acute Myocardial Infarction and Reduces Cardiac and Vascular Inflammation in Ischemic Heart Failure

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 396
Author(s):  
Wolf-Stephan Rudi ◽  
Michael Molitor ◽  
Venkata Garlapati ◽  
Stefanie Finger ◽  
Johannes Wild ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Bone Marrow ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Vascular Inflammation ◽  
Ace Inhibition ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Ischemic Heart Failure

Aims: Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a cornerstone of drug therapy after myocardial infarction (MI) and improve left ventricular function and survival. We aimed to elucidate the impact of early treatment with the ACE inhibitor ramipril on the hematopoietic response after MI, as well as on the chronic systemic and vascular inflammation. Methods and Results: In a mouse model of MI, induced by permanent ligation of the left anterior descending artery, immediate initiation of treatment with ramipril (10 mg/k/d via drinking water) reduced cardiac inflammation and the number of circulating inflammatory monocytes, whereas left ventricular function was not altered significantly, respectively. This effect was accompanied by enhanced retention of hematopoietic stem cells, Lin−Sca1−c-Kit+CD34+CD16/32+ granulocyte–macrophage progenitors (GMP) and Lin−Sca1−c-Kit+CD150−CD48− multipotent progenitors (MPP) in the bone marrow, with an upregulation of the niche factors Angiopoetin 1 and Kitl at 7 d post MI. Long-term ACE inhibition for 28 d limited vascular inflammation, particularly the infiltration of Ly6Chigh monocytes/macrophages, and reduced superoxide formation, resulting in improved endothelial function in mice with ischemic heart failure. Conclusion: ACE inhibition modulates the myeloid inflammatory response after MI due to the retention of myeloid precursor cells in their bone marrow reservoir. This results in a reduction in cardiac and vascular inflammation with improvement in survival after MI.

ECHOCARDIOGRAPHY IN PATIENTS WITH HEART FAILURE: REDUCED AND PRESERVED LEFT VENTRICULAR FUNCTION: PP.1.14

2010 ◽  
Vol 28 ◽  
pp. e50-e51
Author(s):  
F Santi ◽  
ER Cosentino ◽  
D Degli Esposti ◽  
ER Rinaldi ◽  
S Bacchelli ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Patients With Heart Failure
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