Solitary bone plasmacytoma

AbstractAn abnormal serum immunoglobulin free light chain (FLC) ratio at diagnosis may identify risk of progression to myeloma in patients with solitary bone plasmacytoma (SBP). In the cohort of 116 patients, 43 have progressed to myeloma, with a median time to progression of 1.8 years. The FLC ratio was determined in all 116 patients on serum collected at time of diagnosis and was abnormal in 54 patients (47%). An abnormal FLC ratio was associated with a higher risk of progression to myeloma (P = .039). The risk of progression at 5 years was 44% in patients with an abnormal serum FLC ratio at diagnosis compared with 26% in those with a normal FLC ratio. One to 2 years following diagnosis, a persistent serum M protein level of 5 g/L (0.5 g/dL) or higher was an additional risk factor for progression. A risk stratification model was constructed using the 2 variables of FLC ratio and M protein level: patients with a normal FLC ratio at baseline and M protein level less than 5 g/L (0.5 g/dL) at 1 to 2 years following diagnosis (low risk, n = 31); with either risk factor abnormal (intermediate risk, n = 26); and with both an abnormal FLC ratio and M protein level of 5 g/L (0.5 g/dL) or higher (high risk, n = 18). The corresponding progression rates at 5 years were significantly different in the low, intermediate, and high groups: 13%, 26%, and 62%, respectively (P < .001).

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Surgical Resection of Solitary Bone Plasmacytoma of Atlas and Reconstruction with 3-Dimensional−Printed Titanium Patient-Specific Implant

World Neurosurgery ◽

10.1016/j.wneu.2020.04.041 ◽

2020 ◽

Vol 139 ◽

pp. 322-329

Author(s):

Yuxi Li ◽

Guan Zheng ◽

Ting Liu ◽

Yuwei Liang ◽

Jiajun Huang ◽

...

Keyword(s):

Surgical Resection ◽

Patient Specific ◽

3 Dimensional ◽

Solitary Bone Plasmacytoma

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Exploring Solitary Bone Plasmacytoma: A Rare Case Report

International Journal of Clinical Case Reports and Reviews ◽

10.31579/2690-4861/164 ◽

2021 ◽

Vol 9 (1) ◽

pp. 01-06

Author(s):

Manuela B. Pucca ◽

Pablo A. Brito-Souza ◽

Gabriel M. Alexandre-Silva ◽

Ana C. S. Oliveira ◽

Kim Tavares Mesquita ◽

...

Keyword(s):

Quality Of Life ◽

Rare Case ◽

Clinical Case ◽

Plasma Cells ◽

Malignant Neoplasms ◽

Plasma Cell Neoplasms ◽

Rare Case Report ◽

Solitary Bone Plasmacytoma ◽

Aggressive Tumor

The Solitary Bone Plasmacytoma (SBP) is a rare oncologic disease corresponding to less than 5% of the malignant neoplasms of the plasma cells. It is characterized as a localized aggressive tumor consequent to the accumulation of monoclonal plasma cell neoplasms and, due to the rarity of the disease, there are only few clinical studies reporting it especially regarding prognostic factors and treatment. Here, we report a fatal clinical case of SPB in Roraima, the northernmost state of Brazil. The study shows a case of solitary bone plasmacytoma on the femur, where the patient was submitted to the preconized radiotherapy cycles. However, over approximately four-years following the diagnose, the patient required multi-modal approach to guarantee quality of life during the survival time. Finally, this study explores SBP-related issues and examines the challenges physicians face when managing the care of patients with SBP.

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Pathological axis fracture secondary to a solitary bone plasmacytoma: Two cases and a literature review

Surgical Neurology International ◽

10.25259/sni_253_2021 ◽

2021 ◽

Vol 12 ◽

pp. 165

Author(s):

Ratko Yurac ◽

Alvaro Silva ◽

Matias Delgado ◽

Marilaura Nuñez ◽

Juan Lopez ◽

...

Keyword(s):

Literature Review ◽

Neurological Deficits ◽

Resonance Imaging ◽

Cervical Instability ◽

Conventional Radiation ◽

Plasma Cell Neoplasms ◽

Solitary Bone Plasmacytoma ◽

Clinical Records

Background: Solitay bone plasmocytoma (SBP) account for just 5–10% of all plasma cell neoplasms. They are infrequent in the cervical spine, especially involving the C0–C2 segment. In this article we conducted a literature review and present the diagnosis, management and long term course of two patients with SBP of C2 causing cervical instability. Methods: We assessed the clinical records of two patients with SBP in C2 and cervical instability attributed to SP-B involving C2. Both patients presented with progressive, severe cervicalgia, and the “sensation” of skull instability. Magnetic resonance imaging revealed an extensive, infiltrative lesion involving C2 vertebral body and lateral masses, consistent with a plasmacytoma. Results: Both patients underwent emergency posterior surgical stabilization with craniocervical fixation; this was accompanied by a C2 transpedicular biopsy. Postoperatively, patients exhibited no focal neurological deficits and rapidly became pain free. They additional recieved 25 sessions of local conventional radiation therapy. Both patients are doing well as respective 2 and 7-year follow-up. Conclusion: Although rare, unstable SBP may present atypical cervical location that readily responds to surgical descompression/fusion and radiotherapy.

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PET/CT of solitary bone plasmacytoma

10.53347/rid-95751 ◽

2021 ◽

Author(s):

Artyom Artashesyan

Keyword(s):

Pet Ct ◽

Solitary Bone Plasmacytoma

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Solitary bone plasmacytoma compression injury disguised as back pain: a case report

Spinal Cord Series and Cases ◽

10.1038/s41394-019-0161-4 ◽

2019 ◽

Vol 5 (1) ◽

Author(s):

Steven D. Jackson ◽

Bethany A. Wiering ◽

Amanda A. Herrmann ◽

MacKenna A. Hinz ◽

Leah R. Hanson

Keyword(s):

Back Pain ◽

Case Report ◽

Compression Injury ◽

Solitary Bone Plasmacytoma

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Magnetic resonance imaging in the staging of solitary plasmacytoma of bone.

Journal of Clinical Oncology ◽

10.1200/jco.1993.11.7.1311 ◽

1993 ◽

Vol 11 (7) ◽

pp. 1311-1315 ◽

Cited By ~ 152

Author(s):

L A Moulopoulos ◽

M A Dimopoulos ◽

D Weber ◽

L Fuller ◽

H I Libshitz ◽

...

Keyword(s):

Magnetic Resonance ◽

Mr Imaging ◽

Primary Tumor ◽

Radiation Treatment ◽

Lumbosacral Spine ◽

Solitary Plasmacytoma ◽

Myeloma Protein ◽

Signal Characteristics ◽

Solitary Bone Plasmacytoma

PURPOSE To assess prospectively the role of magnetic resonance (MR) imaging in the staging of patients with a solitary bone plasmacytoma (SBP). PATIENTS AND METHODS Twelve consecutive patients with an apparent SBP underwent MR imaging of both the primary tumor and the thoracic and lumbosacral spine to seek additional foci of marrow involvement that might have been undetected by standard skeletal survey. All patients received megavoltage irradiation (total dose, 40 Gy) to the primary lesion. RESULTS MR imaging of the thoracic and lumbosacral spine showed additional foci of marrow replacement in four of 12 patients, with signal characteristics identical to those of the primary tumor. In all four patients, the abnormal protein persisted at greater than 50% of the pretreatment value following radiation treatment. In contrast, the myeloma protein disappeared or was reduced by greater than 50% in five of the six patients with secretory disease and without additional marrow abnormalities. One of four patients progressed to multiple myeloma 10 months after diagnosis with new lesions on conventional radiographs in the same areas as detected previously by MR imaging. CONCLUSION Four of 12 patients considered to have a SBP by standard criteria may have been understaged, because MR imaging showed additional marrow abnormalities consistent with myeloma. MR imaging of the spine may contribute to the initial staging of SBP, especially since some patients may be cured with radiotherapy.

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