Gastric Sleeve Surgery Shifts Immunophenotyping Polarization From M1 To M2 With A Shift From Pro-inflammatory To Anti-inflammatory Pattern In Morbid Obese Subjects.

2014 ◽  
Author(s):  
Nasser Rizk ◽  
Moataz Bashah ◽  
Amina Fadel
Keyword(s):  
Gastric Sleeve ◽  
Obese Subjects ◽  
Morbid Obese ◽  
Inflammatory Pattern ◽  
Gastric Sleeve Surgery ◽  
Anti Inflammatory

scholarly journals Impact of sustained weight loss achieved through gastric gastric sleeve surgery with circulating level of obestatin hormone in Iraqi obese subjects

2014 ◽  
Vol 7 (5) ◽  
pp. 37-44
Author(s):  
Dr. Zainab A. Razak A. Ghani ◽  
◽  
Dr. Ramiz Sami Mukhtar ◽  
Dr. MuayadAbass Fadhel ◽  
Prof. Dr. Kisma M Turki
Keyword(s):  
Weight Loss ◽  
Gastric Sleeve ◽  
Sustained Weight Loss ◽  
Obese Subjects ◽  
Gastric Sleeve Surgery

scholarly journals Impact Of Sustained Weight Loss Achieved Through Gastric Gastric Sleeve Surgery With Circulating Level Of Obestatin Hormone In Iraqi Obese Subjects

2014 ◽  
Vol 13 (5) ◽  
pp. 54-60
Author(s):  
Dr. Zainab A Razak A. Ghani ◽  
◽  
Dr. Ramiz Sami Mukhtar ◽  
Dr. MuayadAbass Fadhel ◽  
Prof. Dr. Kisma M. Turki
Keyword(s):  
Weight Loss ◽  
Gastric Sleeve ◽  
Sustained Weight Loss ◽  
Obese Subjects ◽  
Gastric Sleeve Surgery

scholarly journals Decreased TLR3 in Hyperplastic Adipose Tissue, Blood and Inflamed Adipocytes is Related to Metabolic Inflammation

2018 ◽  
Vol 51 (3) ◽  
pp. 1051-1068 ◽  
Author(s):  
Jèssica Latorre ◽  
José M. Moreno-Navarrete ◽  
Mónica Sabater ◽  
Maria Buxo ◽  
José I. Rodriguez-Hermosa ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Low Grade ◽  
Metabolic Inflammation ◽  
Fat Depots ◽  
Acute Surgery ◽  
Obese Subjects ◽  
Anti Inflammatory ◽  
The Impact

Background/Aims: Obesity is characterized by the immune activation that eventually dampens insulin sensitivity and changes metabolism. This study explores the impact of different inflammatory/ anti-inflammatory paradigms on the expression of toll-like receptors (TLR) found in adipocyte cultures, adipose tissue, and blood. Methods: We evaluated by real time PCR the impact of acute surgery stress in vivo (adipose tissue) and macrophages (MCM) in vitro (adipocytes). Weight loss was chosen as an anti-inflammatory model, so TLR were analyzed in fat samples collected before and after bariatric surgery-induced weight loss. Associations with inflammatory and metabolic parameters were analyzed in non-obese and obese subjects, in parallel with gene expression measures taken in blood and isolated adipocytes/ stromal-vascular cells (SVC). Treatments with an agonist of TLR3 were conducted in human adipocyte cultures under normal conditions and upon conditions that simulated the chronic low-grade inflammatory state of obesity. Results: Surgery stress raised TLR1 and TLR8 in subcutaneous (SAT), and TLR2 in SAT and visceral (VAT) adipose tissue, while decreasing VAT TLR3 and TLR4. MCM led to increased TLR2 and diminished TLR3, TLR4, and TLR5 expressions in human adipocytes. The anti-inflammatory impact of weight loss was concomitant with decreased TLR1, TLR3, and TLR8 in SAT. Cross-sectional associations confirmed increased V/ SAT TLR1 and TLR8, and decreased TLR3 in obese patients, as compared with non-obese subjects. As expected, TLR were predominant in SVC and adipocyte precursor cells, even though expression of all of them but TLR8 (very low levels) was also found in ex vivo isolated and in vitro differentiated adipocytes. Among SVC, CD14+ macrophages showed increased TLR1, TLR2, and TLR7, but decreased TLR3 mRNA. The opposite patterns shown for TLR2 and TLR3 in V/ SAT, SVC, and inflamed adipocytes were observed in blood as well, being TLR3 more likely linked to lymphocyte instead of neutrophil counts. On the other hand, decreased TLR3 in adipocytes challenged with MCM dampened lipogenesis and the inflammatory response to Poly(I:C). Conclusion: Functional variations in the expression of TLR found in blood and hypertrophied fat depots, namely decreased TLR3 in lymphocytes and inflamed adipocytes, are linked to metabolic inflammation.

Roux-en-Y gastric bypass and gastric sleeve surgery result in long term bone loss

2020 ◽  
Vol 45 (1) ◽  
pp. 235-246
Author(s):  
Malgorzata M. Brzozowska ◽  
Thach Tran ◽  
Dana Bliuc ◽  
John Jorgensen ◽  
Michael Talbot ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Bone Loss ◽  
Gastric Sleeve ◽  
Gastric Sleeve Surgery

scholarly journals Gastric sleeve surgery in hemodialysis: A case report

2019 ◽  
Vol 57 ◽  
pp. 19-21 ◽  
Author(s):  
Kateir Mariel Contreras Villamizar ◽  
Diana Carolina Afanador Rubio ◽  
Camilo Alberto González González ◽  
Paola Karina García Padilla ◽  
Martha Patricia Rodríguez Sánchez
Keyword(s):  
Case Report ◽  
Gastric Sleeve ◽  
Gastric Sleeve Surgery

scholarly journals Modulation of Anti-Oxidant, Anti-Inflammatory and Metabolism-Controlling Genes Expressions by Ramadan Intermittent Fasting: A Prospective Observational Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1265-1265
Author(s):  
Mohamed Madkour ◽  
Rasha Hassan ◽  
Najla Sherif ◽  
Samir Awadallah ◽  
Ahmed Serafi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Diseases ◽  
Intermittent Fasting ◽  
Gene Expressions ◽  
Antioxidant Genes ◽  
Funding Sources ◽  
Before And After ◽  
Obese Subjects ◽  
Anti Inflammatory ◽  
Sirt1 Gene

Abstract Objectives A mounting evidence confirms the effect of caloric restriction and intermittent fasting in ameliorating body oxidative stress and inflammation. A growing body of evidence supports that chronic inflammation and increased level of oxidative stress augment the way for the development of metabolic diseases, such as diabetes and cancers. Objectives: This research was conducted to examine the effect of Ramadan diurnal intermittent fasting (RDIF) on the gene expression of cellular metabolism (SIRT1 and SIRT3) and antioxidant genes (TFAM, SOD2, and Nrf2). Methods One-hundred fourteen (75 males and 39 females) overweight and obese subjects and twelve healthy body weight controls were followed-up before and after Ramadan. Dietary, anthropometric and biochemical assessments were performed before and at the end of Ramadan fasting month. Results Results showed that the relative gene expressions in obese subjects in comparison to counterpart expressions of controls showed a significant (P < 0.001) increase in the anti-inflammatory cytokine (IL-10), along with significant (P < 0.001) reductions in the proinflammatory cytokines (IL-6 and TNF-alpha). Expression of TFAM, SOD2, and Nrf2 significantly increased at the end of Ramadan (90.5%, 54.1%, and 411.5%, respectively). However, the metabolism-controlling gene (SIRT3) showed a highly significant (P < 0.001) downregulation accompanied by a trend for reduction in the SIRT1 gene at the end of Ramadan month, with % decrements of 61.8% and 10.4%, respectively. Conclusions Results suggest that RIF ameliorates the genetic expression of antioxidant and anti-inflammatory and metabolic regulatory genes. Thus, RIF presumably may entail a protective impact against oxidative stress and its adverse metabolic-related derangements in non-diabetic obese patients. Funding Sources University of Sharjah, UAE.

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