A REVIEW ON MOUTH DISSOLVING TABLETS

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (11) ◽  
pp. 5-14
Author(s):  
S. Rathod ◽  
◽  
M. Phansekar ◽  
A. Bhagwan ◽  
G. Surve
Keyword(s):  
Pharmaceutical Industry ◽  
Oral Cavity ◽  
Spray Drying ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Moisture Treatment ◽  
Additional Water ◽  
Fast Dissolution ◽  
Increasing Demand

Mouth Dissolving Tablets (MDTs) have received ever-increasing demand during the last decade and the field has become a rapidly growing area of research in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several MDT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail MDT technologies based on lyophilization, moulding, sublimation and compaction, as well as approaches to enhance the MDT properties, such as spray drying, moisture treatment, sintering, and use of sugar-based disintegrants.

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

2022 ◽  
Author(s):  
Cloudius Sagandira ◽  
Sinazo Nqeketo ◽  
Kanysile Mhlana ◽  
Thembela Sonti ◽  
Paul Watts ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Continuous Flow ◽  
Industrial Revolution ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
New Paradigm ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Chemistry

Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical...

DOMESTIC APIS AND INTERMEDIATES – THE NEED OF THE HOUR

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (09) ◽  
pp. 5-6
Author(s):  
George Patani ◽  
Keyword(s):  
Pharmaceutical Industry ◽  
Multiple Representations ◽  
Active Pharmaceutical Ingredients ◽  
Current Crisis ◽  
Pharmaceutical Ingredients ◽  
Essential Drugs ◽  
Current Events ◽  
Dear Reader ◽  
The Cost

Dear Reader, As I write this editorial, some of the current events that we are faced with in the pharmaceutical industry in INDIA, bears greatly on my mind. The exponential rise in the cost of a large number of APIs is causing great anguish and stress for formulation manufacturers. The rise in the cost of these APIs or their intermediates sourced from China is attributed as the reason for this increase. As a result, a number of essential drugs are experiencing shortages in various parts of our country. The year 2015 was declared as the year of ACTIVE PHARMACEUTICAL INGREDIENTS (APIs) by the Department of Pharmaceuticals. While we still await the announcement of concessions based on the multiple representations made to the various ministries, the current crisis maybe a god sent opportunity for the domestic API manufacturers to restart manufacturing a number of the APIs that were uneconomical due to price pressures from APIs produced in China

Flow nanoprecipitation of size-controlled d-leucine nanoparticles for spray-drying formulations

2019 ◽  
Vol 4 (10) ◽  
pp. 1861-1868 ◽  
Author(s):  
Bruno Cerra ◽  
Gabriele Mosca ◽  
Maurizio Ricci ◽  
Aurélie Schoubben ◽  
Antimo Gioiello
Keyword(s):  
Spray Drying ◽  
Pulmonary Delivery ◽  
Active Pharmaceutical Ingredients ◽  
Flash Nanoprecipitation ◽  
Pharmaceutical Ingredients ◽  
Size Controlled

A flow-based flash nanoprecipitation of size-controlled d-leucine nanoparticles as glidants for pulmonary delivery of active pharmaceutical ingredients.

Spray Drying Tailored Mannitol Carrier Particles for Dry Powder Inhalation with Differently Shaped Active Pharmaceutical Ingredients

Process-Spray ◽  
2016 ◽  
pp. 517-566 ◽  
Author(s):  
Mathias Mönckedieck ◽  
Jens Kamplade ◽  
Eva Maria Littringer ◽  
Axel Mescher ◽  
Srikanth Gopireddy ◽  
...  
Keyword(s):  
Spray Drying ◽  
Active Pharmaceutical Ingredients ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Pharmaceutical Ingredients

scholarly journals Funding of clinical trials in Brazil for the development of new drugs: who are the sponsors?

2015 ◽  
Vol 2 (4) ◽  
pp. 75 ◽  
Author(s):  
Ricardo Eccard da Silva ◽  
Angélica Amorim Amato ◽  
Maria Rita Carvalho Garbi Novaes
Keyword(s):  
Clinical Trials ◽  
Pharmaceutical Industry ◽  
The Other ◽  
New Drugs ◽  
Essential Medicines ◽  
Neglected Diseases ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Funding Sources ◽  
Other Hand

<p class="abstract"><strong>Background:</strong> A low rate of investment in science it is directly impacts the technological independence and capacity in health care costs. Knowledge of funding sources is critical to understand the problem and formulates hypotheses for future studies.</p><p class="abstract"><strong>Methods:</strong> Two databases were used: the System for Control of Clinical Research (SCCR) from the Brazilian Health Surveillance Agency (Anvisa), and the International Clinical Trials Registry Platform (ICTRP).  </p><p class="abstract"><strong>Results:</strong> From 2009 to 2012, 77% of the clinical trials approved by Anvisa were sponsored by transnational pharmaceutical industry. On the other hand, the national pharmaceutical industry sponsored 8% of the trials over the same period. The most frequent sponsor of clinical trials involving drugs registered in the ICTRP from 2011 to 2012 was the transnational pharmaceutical industry (43%). Among the trials with national sponsors, are those involving neglected diseases such as chronic hepatitis C (ICD X B18.2), cutaneous leishmaniasis (ICD X B55.1) and yellow fever (ICD X A95), which were all sponsored by national governmental foundations. None of the active pharmaceutical ingredients studied by the transnational pharmaceutical industry or the transnational biopharmaceutical company were in the national list of essential medicines. On the other hand, 83% and 66.6% of the active pharmaceutical ingredients studied by national private universities and the international governmental agency, respectively, are in the national list of essential medicines.  </p><p class="abstract"><strong>Conclusions:</strong> The national pharmaceutical industry and government still invests little in Research and Development (R&amp;D) activities, when compared with transnational industries. This affects directly its technological and innovation ability.</p>

scholarly journals Dependence of anticonvulsant activity of 1-aryl-1, 5-dihydro-4H-pyrazole (3,4-d) pyrimidine-4-one derivatives on biopharmaceutical factors

2017 ◽  
Vol 6 (7) ◽  
pp. 1552 ◽  
Author(s):  
Anna I. Severina ◽  
Dmitryi P. Kavraiskyi ◽  
Inna V. Kovalevska ◽  
Sergey Yu. Shtrygol’ ◽  
Elena A. Ruban ◽  
...  
Keyword(s):  
Particle Size ◽  
Anticonvulsant Activity ◽  
Anticonvulsant Effect ◽  
Active Pharmaceutical Ingredients ◽  
Solubility In Water ◽  
Pharmaceutical Ingredients ◽  
Degree Of Dispersion ◽  
Significant Dependence ◽  
Physicochemical Factors ◽  
Fast Dissolution

Background: We have synthesized three 5-R-1-aryl-1,5-dihydro-4Н-pyrazole(3,4-d)pyrimidine-4-one derivatives that previously have demonstrated powerful anticonvulsant activity. A great number of physicochemical factors are known to influence on bioavailability and stability of active pharmaceutical ingredients. Therefore the purpose of research was to determine the effect of purification technology and dispersibility of 5-R-1-aryl-1, 5-dihydro-4Н-pyrazole (3,4-d) pyrimidine-4-one derivatives on their anticonvulsant activity.Methods: The anticonvulsant effect of this compounds was studied in a model of pentylenetetrazole-induced seizure in mice.Results: The results obtained revealed the optimal solvent for recrystallization of compounds to be isopropanol: compounds, purified by recrystallization from isopropanol, had higher solubility in water and tween; also, they had a tendency to increase anticonvulsant activity. It was found that there is a significant dependence of the latter on compound’s dispersion - the smaller the size of crystals the higher anticonvulsant activity.Conclusions: The dependence of anticonvulsant activity of compounds on the degree of dispersion was proved: the smaller particle size the higher anticonvulsant activity. This can be explained by fast dissolution of fine-dispersed substances, thus increasing the bioavailability if the compounds studied.

In-Flow Flash Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles for Spray-Drying Formulations

2019 ◽  
Author(s):  
Bruno Cerra ◽  
Mosca Gabriele ◽  
Maurizio Ricci ◽  
Aurelie Schoubben ◽  
Antimo Gioiello
Keyword(s):  
Spray Drying ◽  
Marked Improvement ◽  
Sem Analysis ◽  
Active Pharmaceutical Ingredients ◽  
Flash Nanoprecipitation ◽  
Pharmaceutical Ingredients ◽  
Aerodynamic Properties ◽  
Economic Method ◽  
Physical Mixing ◽  
Size Controlled

<p>In this work we report the development of a cheap and scalable flow-based flash nanoprecipitation approach to prepare D-leucine nanoparticles particularly useful as glidants in dry powder for inhalation. Starting from preliminary batch screens, the process was successfully optimized and scaled-up under mesofluidic conditions. The nebulization with both mini and nano spray-dryer, the SEM analysis of nanoparticles and the aerodynamic evaluation of a formulation obtained by physical mixing of atomized D-leucine powders with budenoside showed an excellent decrease in particle size without altering the morphology, and a marked improvement in the aerodynamic properties of the drug. This simple and economic method by physical mixing of leucine with micronized active pharmaceutical ingredients can represent a valid alternative to co-spray-drying.</p>

Heterogeneous vanadium catalyzed oxidative cleavage of olefins for sustainable synthesis of carboxylic acids

2021 ◽  
Author(s):  
Rahul Upadhayay ◽  
Rohit Rana ◽  
Aakriti Sood ◽  
Vikash Singh ◽  
Rahul Kumar ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Carboxylic Acids ◽  
Oxidative Cleavage ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
A Priority

The development of green and sustainable processes to synthesize active pharmaceutical ingredients and key starting materials is a priority for the pharmaceutical industry. A green and sustainable protocol for the...

15.1 Flow Chemistry in the Pharmaceutical Industry: Part 1

2018 ◽  
Author(s):  
A. G. O’Brien
Keyword(s):  
Pharmaceutical Industry ◽  
Large Scale ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
Flow Process ◽  
Pharmaceutical Ingredients ◽  
Multistep Synthesis

Abstract The use of flow chemistry in the single- and multistep synthesis of active pharmaceutical ingredients has been well demonstrated. The pharmaceutical industry is now taking the next steps towards integration of flow chemistry into large-scale commercialized processes, which can effectively supply patient populations. This chapter details advances in this area, and outlines the data and knowledge required to select, develop, scale, and commercialize an efficient flow process.

Engineering Active Pharmaceutical Ingredients by Spray Drying: Effects on Physical Properties and In Vitro Dissolution

2012 ◽  
Vol 30 (9) ◽  
pp. 905-913 ◽  
Author(s):  
R. M. Martins ◽  
M. O. Machado ◽  
S. V. Pereira ◽  
A. B. F. L. Nosari ◽  
L. A. Tacon ◽  
...  
Keyword(s):  
Physical Properties ◽  
Spray Drying ◽  
In Vitro Dissolution ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients
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