scholarly journals Acute Pulmonary Embolism Decreases Adenosine Plasma Levels in Anesthetized Pigs

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
François Kerbaul ◽  
Youlet By ◽  
Vlad Gariboldi ◽  
Choukri Mekkaoui ◽  
Pierre Fesler ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Plasma Levels ◽  
Coupling Efficiency ◽  
Systolic Pressure ◽  
Vascular Impedance ◽  
Pulmonary Vasoconstriction ◽  
Volume Relationship ◽  
Pressure Volume Relationship ◽  
Pulmonary Embolization ◽  
Pulmonary Arterial

Adenosine plays a role in pulmonary arterial (PA) resistance due to its vasodilator properties. However, the behavior of adenosine plasma levels (APLs) during pulmonary embolism remains unknown. We investigated the effects of gradual pulmonary embolism on right ventricular (RV) contractility and PA coupling and on APLs in an piglet experimental model of RV failure. PA distal resistance by pressure-flow relationships and pulmonary vascular impedance were measured. RV contractility was determined by the end-systolic pressure-volume relationship (Ees), PA effective elastance by the end-diastolic to end-systolic relationship (Ea), and RV-PA coupling efficiency by the Ees/Ea ratio. APLs were measured before and during gradual pulmonary embolization. PA embolism increased PA resistance and elastance, increased Ea from to  mmHg/mL, decreased Ees from to  mmHg/mL, and decreased Ees/Ea from to . APLs decreased from to  μM in the systemic bed and from to  μM in the pulmonary bed during embolism procedure. Pulmonary embolism worsens PA hemodynamics and RV-PA coupling. APLs were reduced, both in the systemic and in the pulmonary bed, leading then to pulmonary vasoconstriction.

Area beneath the end-systolic pressure-volume relationship as an index of inotropicstate in intact dogs

1986 ◽  
Vol 18 ◽  
pp. 20-20 ◽  
Author(s):  
A CROTTOGINI ◽  
J BARRA ◽  
M RODRIGUEZCHATRUC ◽  
R ARMENTANO ◽  
E CABRERA ◽  
...  
Keyword(s):  
Systolic Pressure ◽  
Volume Relationship ◽  
Pressure Volume Relationship

Right Ventricular Pressure-Volume Relationship to Evaluate Right Ventricular-Pulmonary Arterial Coupling and Energetics

2015 ◽  
Vol 21 (10) ◽  
pp. S152
Author(s):  
Takafumi Sakamoto ◽  
Kohtaro Abe ◽  
Kazuya Hosokawa ◽  
Keiji Oi ◽  
Yasushi Mukai ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Ventricular Pressure ◽  
Volume Relationship ◽  
Pressure Volume Relationship ◽  
Pulmonary Arterial

scholarly journals Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function

1995 ◽  
Vol 109 (4) ◽  
pp. 780-786 ◽  
Author(s):  
Osamu Kawaguchi ◽  
John S. Sapirstein ◽  
William B. Daily ◽  
Walter E. Pae ◽  
William S. Pierce
Keyword(s):  
Heart Function ◽  
Systolic Pressure ◽  
Left Ventricular ◽  
Volume Relationship ◽  
Pressure Volume Relationship

Pressure-volume-based single-beat estimations cannot predict left ventricular contractility in vivo

2002 ◽  
Vol 282 (5) ◽  
pp. H1739-H1750 ◽  
Author(s):  
Knut E. Kjørstad ◽  
Christian Korvald ◽  
Truls Myrmel
Keyword(s):  
Systolic Pressure ◽  
Left Ventricular ◽  
Clinical Applications ◽  
Volume Data ◽  
Ventricular Contractility ◽  
Limits Of Agreement ◽  
Volume Relationship ◽  
Pressure Volume Relationship ◽  
State Pressure

The end-systolic pressure-volume relationship is regarded as a useful index for assessing the contractile state of the heart. However, the need for preload alterations has been a serious limitation to its clinical applications, and there have been numerous attempts to develop a method for calculating contractility based on one single pressure-volume loop. We have evaluated four of these methods. Pressure-volume data were obtained by combined pressure and conductance catheters in 37 pigs. All four methods were applied to 88 steady-state pressure-volume files, including eight files sampled during dopamine infusions. Estimates of single-beat contractility (elastance) were compared with preload-varied multiple-beat elastance [ E es(MB)]. All methods had a low average bias (−0.3 to 0.5 mmHg/ml) but limits of agreement (±2 SD) were unacceptably high (±2.6 to ±3.8 mmHg/ml). In the dopamine group, E es(MB) showed an increase of 1.7 ± 0.8 mmHg/ml (mean ± SD) compared with baseline ( P < 0.001). None of the single-beat methods predicted this increase in contractility. It is therefore doubtful whether any of the methods allow for single-beat assessment of contractility.

Chronic Changes of End-Systolic Pressure-Volume Relationship After Regional Myocardial Infarction

1995 ◽  
Vol 10 (6) ◽  
pp. 652-664 ◽  
Author(s):  
Hidehiro Nakajima ◽  
Hisako O. Nakajima ◽  
Robert L. Hammond ◽  
Gregory A. Thomas ◽  
Susumu Isoda ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Systolic Pressure ◽  
Volume Relationship ◽  
Pressure Volume Relationship
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