scholarly journals Development and Evaluation of Sustained Release Tablet of Betahistine Hydrochloride Using Ion Exchange Resin Tulsion T344

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Vijay D. Wagh ◽  
Nilesh Pawar
Keyword(s):  
Ion Exchange ◽  
Sustained Release ◽  
Exchange Resin ◽  
Mixing Time ◽  
Drug Loading ◽  
Cation Exchange Resin ◽  
Ion Exchange Resin ◽  
Activation Effect ◽  
Weight Variation

An attempt was made to sustain the release of Betahistine hydrochloride by complexation technique using strong cation-exchange resin, Tulsion T344. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, swelling time, ratio of drug : resin, and temperature. The resinate was evaluated for micromeritic properties and characterized using XRPD and IR. For resinate sustained release tablets were formulated using hydoxypropyl methylcellulose K100M. The tablets were evaluated for hardness, thickness, friability, drug content, weight variation, and in vitro drug release. Tablets thus formulated (Batch T-3) provided sustained release of drug over a period of 12 h. The release of Betahistine HCl from resinate controls the diffusion of drug molecules through the polymeric material into aqueous medium. Results showed that Betahistine HCl was formulated into a sustained dosage form as an alternative to the conventional tablet.

Improvement of drug loading onto ion exchange resin by cyclodextrin inclusion complex

2012 ◽  
Vol 39 (11) ◽  
pp. 1672-1680 ◽  
Author(s):  
Wipada Samprasit ◽  
Theerasak Rojanarata ◽  
Prasert Akkaramongkolporn ◽  
Tanasait Ngawhirunpat ◽  
Warisada Sila-on ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Inclusion Complex ◽  
Exchange Resin ◽  
Drug Loading ◽  
Ion Exchange Resin ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

scholarly journals Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 370-379 ◽  
Author(s):  
Goutham R. Adelli ◽  
Sai Prachetan Balguri ◽  
Prakash Bhagav ◽  
Vijayasankar Raman ◽  
Soumyajit Majumdar
Keyword(s):  
Ion Exchange ◽  
Sustained Release ◽  
Exchange Resin ◽  
Diclofenac Sodium ◽  
Ion Exchange Resin ◽  
Sodium Ion ◽  
Ocular Delivery ◽  
Cast Films

scholarly journals Preparation and characterization of taste masked valsartan by ion-exchange resin approach

2018 ◽  
pp. 11-25
Keyword(s):  
Complex Formation ◽  
Ion Exchange ◽  
Bitter Taste ◽  
Exchange Resin ◽  
Mixing Time ◽  
Spectroscopic Method ◽  
Ion Exchange Resin ◽  
Drug Formulation ◽  
Taste Masking ◽  
Scanning Calorimetry

The bitter taste is one of the most important drug formulation problems. The unpleasant taste leads to noncompliance, which consequently decreases the therapeutic efficacy of the drug. Therefore, masking of bitter taste is very important in drug formulation. In this study an antihypertensive drug, valsartan, which is a weak acid with bitter taste, was used as a model drug to mask its taste with dowex2 (weak base anion exchange resin). The taste masking of a drug using ion exchange resin basically depends on the complex formation between the drug and a specific type of resin. Complex formation under various preparation conditions including; the ratio of drug to resin, mixing time, the pH of the processing medium and the concentration of valsartan was investigated in this study. Optimum conditions for complex formation and maximum drug load were obtained at a drug-resin ratio 1:8, mixing time 4 hours, pH 6.8, temperature 50º C and drug concentration 0.02% w/v. The drug resin ate complex was evaluated for the drug content, taste, drug release and molecular properties. The resinate formation was confirmed using different analytical techniques like thermal analysis using differential scanning calorimetry (DSC), spectroscopic method like Fourier transform infrared spectroscopy (FTIR) and by X-ray powder diffraction analysis (XRPD).

scholarly journals The Phosphorylated Carbohydrate Intermediates from Erythrocytes in Hereditary Spherocytosis

Blood ◽  
1964 ◽  
Vol 23 (4) ◽  
pp. 417-426 ◽  
Author(s):  
A. WILLIAM SHAFER
Keyword(s):  
Ion Exchange ◽  
Exchange Resin ◽  
Hereditary Spherocytosis ◽  
Specific Activity ◽  
Ion Exchange Resin ◽  
Relative Specific Activity ◽  
Definite Difference ◽  
Normal Adults

Abstract The phosphorylated carbohydrate intermediates of erythrocytes from normal adults and from five patients with hereditary spherocytosis (HS) were labeled in vitro with P32 orthophosphate and then separated on columns of ion exchange resin. No qualitative or quantitative differences were found between normal and HS erythrocytes. The relative specific activity of each phosphate of 2, 3 DPG was the same; whereas the phosphate attached to ribose in ADP and ATP was not labeled. The nucleotides were labeled at a much faster rate than DPG. When the erythrocytes were washed 6 or more times, the specific activity of Pi approached that of DPG. No definite difference was found in the rate of labeling of the intermediates from normal and HS erythrocytes.

Ion Exchange Resin Separation of Metals Occurring in Plant Material

1966 ◽  
Vol 49 (2) ◽  
pp. 298-305
Author(s):  
Eugene A Breault
Keyword(s):  
Ion Exchange ◽  
Exchange Resin ◽  
Cation Exchange Resin ◽  
Ion Exchange Resin ◽  
Acid Solutions ◽  
Uniform Particles ◽  
Hydrochloric Acid Solutions ◽  
Ion Exchange Separation ◽  
Resin Separation ◽  
Unified Method

Abstract The study of the separation of metallic chlorides on Amberlite CG-120 (200–400 mesh) cation exchange resin was continvied. Na, K, Mo, Al, Ca, and Fe have been separated by hydrochloric acid solutions and determined by polarography or flame photometry. Semimicro quantities of these metals can be separated from each other with a minimum of eluting agent, small resin beds, and simple equipment. Mechanical grading of the air-dried resin was used to obtain more uniform particles. The ion exchange separation scheme offers advantages over present official procedures, and it should provide a unified method for the analysis of metals in mixtures. Further study is recommended.

Preparation and characterization of taste masked valsartan by ion-exchange resin approach

10.32947/358 ◽  
2018 ◽  
Vol 18 (1) ◽  
pp. 11-25
Keyword(s):  
Complex Formation ◽  
Ion Exchange ◽  
Bitter Taste ◽  
Exchange Resin ◽  
Mixing Time ◽  
Spectroscopic Method ◽  
Ion Exchange Resin ◽  
Drug Formulation ◽  
Taste Masking ◽  
Scanning Calorimetry

The bitter taste is one of the most important drug formulation problems. The unpleasant taste leads to noncompliance, which consequently decreases the therapeutic efficacy of the drug. Therefore, masking of bitter taste is very important in drug formulation. In this study an antihypertensive drug, valsartan, which is a weak acid with bitter taste, was used as a model drug to mask its taste with dowex2 (weak base anion exchange resin). The taste masking of a drug using ion exchange resin basically depends on the complex formation between the drug and a specific type of resin. Complex formation under various preparation conditions including; the ratio of drug to resin, mixing time, the pH of the processing medium and the concentration of valsartan was investigated in this study. Optimum conditions for complex formation and maximum drug load were obtained at a drug-resin ratio 1:8, mixing time 4 hours, pH 6.8, temperature 50º C and drug concentration 0.02% w/v. The drug resin ate complex was evaluated for the drug content, taste, drug release and molecular properties. The resinate formation was confirmed using different analytical techniques like thermal analysis using differential scanning calorimetry (DSC), spectroscopic method like Fourier transform infrared spectroscopy (FTIR) and by X-ray powder diffraction analysis (XRPD).

scholarly journals Removal of lead, cadmium and copper ions from aqueous solutions by using ion exchange resin C 160

2016 ◽  
Vol 32 (4) ◽  
pp. 129-140 ◽  
Author(s):  
Agnieszka Bożęcka ◽  
Monika Orlof-Naturalna ◽  
Stanisława Sanak-Rydlewska
Keyword(s):  
Ion Exchange ◽  
Aqueous Solutions ◽  
Sorption Capacity ◽  
Exchange Resin ◽  
Copper Ions ◽  
Exchange Process ◽  
Cation Exchange Resin ◽  
Ion Exchange Resin ◽  
Adsorption Model ◽  
Ion Exchange Process

Abstract Industrial waste solutions may contain toxic Pb, Cu, Cd and other metal ions. These ions may also be components of leachates in landfills of ores. The toxicity of the ionic forms of these metals is high. For this reason the paper presents the results of studies on one of the methods to reduce their concentration in aqueous solutions. The article presents the results of studies on the removal of Pb2+, Cd2+ and Cu2+ ions from model aqueous solutions with synthetic ion exchange resin C 160 produced by Purolite. The investigated ion exchanger contains sulfonic acid groups (-SO3H) in its structure and is a strongly acidic cation-exchange resin. The range of the studied initial concentrations of the Pb2+, Cd2+ and Cu2+ ions in the solutions was from 6.25 mg/L to 109.39 mg/L. The results confirmed that the used ion exchange resin C160 efficiently removes the above-mentioned ions from the studied solutions. The highest degree of purification was achieved in lead solutions for the assumed range of concentrations and conditions of the ion exchange process. It reached 99.9%. In the case of other solutions, the ion exchange process occurs with lower efficiency, however it remains high and amounts to over 90% for all the ions. The results of research were interpreted on the basis of the Langmuir adsorption model. For each studied ion, sorption capacity of the ion exchange resin increases until the saturation and equilibrium state is reached. Based on the interpretation of the Langmuir equation coefficients, an indication can be made that the studied ion exchange resin has a major sorption capacity towards the copper ions. In their case, the highest value of constant qmax was obtained in the Langmuir isotherm. For Cu2+ ions it was 468.42 mg/g. For Pb2+ and Cd2+ ions, this parameter reached the values of 112.17 mg/g and 31.76 mg/g, respectively. Ion exchange resin C 160 shows the highest affinity for the Pb2+ ions. In this case, the achieved value of coefficient b is highest and equals 1.437 L/mg.

Development of pyrolytic monolithic carbon composites for the conditioning of spent ion exchange resins

2012 ◽  
Vol 1475 ◽  
Author(s):  
Pamela B. Ramos ◽  
Néstor O. Fuentes ◽  
Vittorio Luca
Keyword(s):  
Ion Exchange ◽  
Exchange Resin ◽  
Cation Exchange Resin ◽  
Processing Parameters ◽  
Ion Exchange Resin ◽  
Mathematical Functions ◽  
Waste Forms ◽  
Resin Beads ◽  
Temperature Ramp ◽  
Exchange Resins

ABSTRACTThe pyrolysis of ion exchange resin beads that are used for the purification of water in reactor primary- and secondary-cooling circuits can result in stable and leach resistant carbonaceous products. However, free flowing beads are less desirable waste forms for disposal in sub-surface or surface repositories than monolithic masses of low porosity. We have investigated the pyrolysis of polymeric resin – cation exchange resin composites to give mechanically robust and chemically durable monolithic carbonaceous waste forms that are suitable for repository disposition. Also investigated was the dependence of product properties on various processing parameters (temperature ramp and final temperature). As a first approach, epoxy resins were used for the preparation of monoliths since such resins cure at room temperature and result in a relatively high carbon yield. Carbonaceous monolithic products were prepared at 400, 500, 600, 700 and 800 °C using a temperature ramp of 2°C/min. The products were maintained at the chosen temperatures for a period of one hour. Mass losses, volume reduction, hardness and compressive strength were measured and mathematical functions are proposed to describe the measured values of these properties. The carbon monoliths were observed to be mechanically robust.

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