Effect of silicon supplementation on bone and mineral (calcium, magnesium, and silicon) status in ovariectomized rats fed with low- and high-calcium diet

2020 ◽  
Vol 37 (07) ◽  
pp. 129-138
Author(s):  
Mi-Kyeong Choi ◽  
Mi-Hyun Kim ◽  
Yun-Jung Bae

2007 ◽  
Vol 292 (2) ◽  
pp. E443-E452 ◽  
Author(s):  
Narattaphol Charoenphandhu ◽  
Kukiat Tudpor ◽  
Kanogwun Thongchote ◽  
Wasana Saengamnart ◽  
Supaporn Puntheeranurak ◽  
...  

High physiological prolactin induced positive calcium balance by stimulating intestinal calcium absorption, reducing renal calcium excretion, and increasing bone calcium deposition in female rats. Although prolactin-induced increase in trabecular bone calcium deposition was absent after ovariectomy, its effects on cortical bones were still controversial. The present investigation, therefore, aimed to study the effect of in vivo long-term high physiological prolactin induced by either anterior pituitary (AP) transplantation or 2.5 mg/kg prolactin injection on cortical bones in ovariectomized rats. Since the presence of prolactin receptors (PRLR) in different bones of normal adult rats has not been reported, we first determined mRNA expression of both short- and long-form PRLRs at the cortical sites (tibia and femur) and trabecular sites (calvaria and vertebrae) by using the RT-PCR. Our results showed the mRNA expression of both PRLR isoforms with predominant long form at all sites. However, high prolactin levels induced by AP transplantation in normal rats did not have any effect on the femoral bone mineral density or bone mineral content. By using 45Ca kinetic study, 2.5 mg/kg prolactin did not alter bone formation, bone resorption, calcium deposition, and total calcium content in tibia and femur of adult ovariectomized rats. AP transplantation also had no effect on the cortical total calcium content in adult ovariectomized rats. Because previous work showed that the effects of prolactin were age dependent and could be modulated by high-calcium diet, interactions between prolactin and these two parameters were investigated. The results demonstrated that 2.0% wt/wt high-calcium diet significantly increased the tibial total calcium content in 9-wk-old young AP-grafted ovariectomized rats but decreased the tibial total calcium content in 22-wk-old adult rats. As for the vertebrae, the total calcium contents in both young and adult rats were not changed by high-calcium diet. The present results thus indicated that the adult cortical bones were potentially direct targets of prolactin. Moreover, the effects of high physiological prolactin on cortical bones were age dependent and were observed only under the modulation of high-calcium diet condition.



1980 ◽  
Vol 58 (5) ◽  
pp. 365-371 ◽  
Author(s):  
A. Berthelot ◽  
A. Gairard

1. Hypertension induced by treatment with deoxycorticosterone acetate and sodium chloride was studied in male Sprague-Dawley rats and related to parathyroid hormone secretion. 2. Lack of parathyroid hormone (due to parathyroidectomy) or decreased parathormone secretion (due to a high-calcium diet) partially inhibited the development of arterial hypertension. 3. In contrast, in thyroparathyroidectomized rats supplemented with thyroxine, the administration of parathyroid hormone rapidly elevated arterial blood pressure. 4. Maintaining a physiological concentration of serum calcium in the absence of parathyroid hormone (by feeding a high-calcium diet to parathyroidectomized rats) was not sufficient to establish mineralocorticoid hypertension. 5. These results show that parathyroid hormone is necessary for the complete development of mineralocorticoid hypertension.



Author(s):  
Alyssa K. Phillips‐Eakley ◽  
Mikaela L. McKenney‐Drake ◽  
Martin Bahls ◽  
Sean C. Newcomer ◽  
John S. Radcliffe ◽  
...  


1996 ◽  
Vol 330 ◽  
pp. 271-280 ◽  
Author(s):  
Darrell R. Lester ◽  
Mark F. Seifert




2012 ◽  
Vol 25 (3) ◽  
pp. 126-130 ◽  
Author(s):  
Hiroshi Matsuzaki ◽  
Yasutaka Kajita ◽  
Misao Miwa


1988 ◽  
Vol 15 (3-4) ◽  
pp. 264-270 ◽  
Author(s):  
Teruhiro Nakada ◽  
Isoji Sasagawa ◽  
Hidekatsu Furuta ◽  
Takashi Katayama ◽  
Jun Shimazaki


Hypertension ◽  
1992 ◽  
Vol 19 (1) ◽  
pp. 85-92 ◽  
Author(s):  
I Pörsti ◽  
P Arvola ◽  
H Wuorela ◽  
H Vapaatalo




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