According to the feature of the second oil layer in the west block of Beierxi, this paper investigated the relationship between the permeability contrast and the recovery efficiency, and the relationship between the permeability contrast and the descent range of water cut of polymer flooding, using the numerical simulation. From the comparative analysis of the development effect with different methods of polymer-injection, it got the boundary of the interlayer permeability contrast of the positive and inverted rhythm layer in the second oil layer with the separated zone and separated quality polymer-injection respectively. That provided certain theoretical foundation for carrying on the polymer flooding in the region of interest.