scholarly journals Necrotizing fasciitis: A review of three clinical encounters

2018 ◽  
Vol 5 (1) ◽  
pp. 5
Author(s):  
Jaron Pettis ◽  
Neelam Mulji ◽  
Fernando A. Navarro
Keyword(s):  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Case Reports ◽  
Disease Process ◽  
The United States ◽  
Soft Tissue Infections ◽  
Wound Debridement ◽  
The Third ◽  
First Case ◽  
Necrotizing Soft Tissue Infections

Background: Necrotizing fasciitis is a potentially lethal soft tissue infection characterized by rampant necrosis and destruction of subcutaneous tissues. Current estimates of necrotizing soft tissue infections in the United States are 4.3 infections per 100,000 of the population. Although the incidence of necrotizing soft tissue infections has decreased in the last decade, the toxic and lethal nature of the disease process lends utmost importance to accurate diagnosis and immediate management. The purpose of this review article is to report three cases of necrotizing fasciitis and provide literature review in regards to hallmark characteristics, predisposing risk factors and treatment optimization.Case: The first case depicts a newly diagnosed 43-year-old male HIV patient with necrotizing fasciitis infection characterized by Klebsiella, Serratia and anaerobic bacteria cultures. The second case describes the course of a 71-year-old male diagnosed with necrotizing fasciitis in the setting of a complicated anal fistula characterized by B. fragilis, S. anginosus and Prevotella species. The third and final case describes the course of a 44-year-old female diagnosed with necrotizing fasciitis in the setting of Ludwig’s Angina characterized by Klebsiella and Dubliensis species. Treatment was initiated with extensive wound debridement, multiple washouts and broad antibiotic regimens in all three cases. Additional hyperbaric oxygen therapy was administered in the third case.Conclusions: These case reports illustrate the range of severity and settings in which necrotizing fasciitis can occur. Significant morbidity and mortality rates are associated with a delay in treatment initiation. Given this, it is of utmost importance to develop and maintain a high clinical acumen for necrotizing soft tissue infections.

Necrotizing Soft Tissue Infections Reported with Nonsteroidal Antiinflammatory Drugs

1997 ◽  
Vol 31 (9) ◽  
pp. 1034-1039 ◽  
Author(s):  
Laura H Kahn ◽  
Barbara A Styrt
Keyword(s):  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Case Reports ◽  
Severe Infection ◽  
Antiinflammatory Drug ◽  
Computer Search ◽  
Soft Tissue Infections ◽  
Antiinflammatory Drugs ◽  
Common Features ◽  
Necrotizing Soft Tissue Infections

background: Recent reports of necrotizing fasciitis in children with varicella who received a nonsteroidal antiinflammatory drug (NSAID) recall earlier concerns regarding the possibility of relationships between infections and NSAIDs. We searched the Food and Drug Administration's Spontaneous Reporting System (SRS) for necrotizing soft tissue infections reported in conjunction with the use of NSAIDs, to identify common features. methods: A computer search of NSAID listings in the adverse event database recovered reports with codes for selected infection and necrosis-related diagnostic categories. From review of individual reports classified under these codes, cases were selected if the terms “necrotizing fasciitis,” “necrotic,” or “gangrenous” appeared in the adverse drug reaction description. Demographic, drug use, and disease course information were gathered. findings: Thirty-three cases were identified, of which 10 were fatal. Over two-thirds of the patients were younger than 40 years. Thirty (91%) had a possible portal of entry for infection. Most received NSAIDs for acute conditions including varicella, trauma, and postoperative or postpartum pain; 7 received an NSAID by intramuscular injection. Specific NSAIDs accounting for most reports were also among those likely to be most heavily used in the relevant populations. interpretation: Common features of these rare case reports of necrotizing soft tissue infections with NSAID use include characteristics such as age, portal of infection entry, indication for NSAID use, route of administration, and individual NSAIDs. The total number of SRS cases does not suggest that necrotizing infection is frequent with NSAIDs or likely without other risk factors. Controlled observational studies would help to define any causal contribution of these factors to the evolution of severe infection.

Noma and Necrotizing Fasciitis of the Face and Neck

2021 ◽  
Author(s):  
Lauren E. Miller ◽  
David A. Shaye
Keyword(s):  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Head And Neck ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Superficial Fascia ◽  
Soft Tissue Infections ◽  
Head And Neck Region ◽  
Necrotizing Soft Tissue Infections ◽  
The Face

AbstractNecrotizing fasciitis (NF) is part of the class of necrotizing soft tissue infections characterized by rapid fascial spread and necrosis of the skin, subcutaneous tissue, and superficial fascia. If left untreated, NF can rapidly deteriorate into multiorgan shock and systemic failure. NF most commonly infects the trunk and lower extremities, although it can sometimes present in the head and neck region. This review provides an overview of NF as it relates specifically to the head and neck region, including its associated clinical features and options for treatment. Noma, a related but relatively unknown disease, is then described along with its relationship with severe poverty.

Estimating the Impact of Necrotizing Soft Tissue Infections in the United States: Incidence and Re-Admissions

2020 ◽  
Author(s):  
Addison K. May ◽  
Victor B. Talisa ◽  
David A. Wilfret ◽  
Eileen Bulger ◽  
Wayne Dankner ◽  
...  
Keyword(s):  
United States ◽  
Soft Tissue ◽  
The United States ◽  
Soft Tissue Infections ◽  
Necrotizing Soft Tissue Infections ◽  
The Impact

scholarly journals Contemporary trends in necrotizing soft-tissue infections in the United States

Surgery ◽  
2013 ◽  
Vol 153 (6) ◽  
pp. 819-827 ◽  
Author(s):  
Charles M. Psoinos ◽  
Julie M. Flahive ◽  
Joshua J. Shaw ◽  
YouFu Li ◽  
Sing Chau Ng ◽  
...  
Keyword(s):  
United States ◽  
Soft Tissue ◽  
The United States ◽  
Soft Tissue Infections ◽  
Necrotizing Soft Tissue Infections

scholarly journals Laboratory risk indicator for necrotizing fasciitis: an objective scoring system as a tool for early diagnosis of necrotizing fasciitis

2021 ◽  
Vol 9 (1) ◽  
pp. 102
Author(s):  
Syed Saad ◽  
Panchami P. ◽  
Gulamnabi .
Keyword(s):  
High Risk ◽  
Soft Tissue ◽  
Necrotizing Fasciitis ◽  
Scoring System ◽  
Risk Group ◽  
High Risk Group ◽  
Intermediate Risk ◽  
Soft Tissue Infections ◽  
Necrotizing Soft Tissue Infections ◽  
Lrinec Score

Background: Necrotizing soft tissue infections are often fatal, characterized by extensive necrosis of the subcutaneous tissues and fascia. The mortality of 30-40% reflects the inadequacy of early recognition of necrotizing soft tissue infections. This study emphasizes on the search for a tool that reliably and rapidly identifies patients with NF. An objective of current study was to validate the LRINEC score as a tool for early distinguishing of necrotizing fasciitis from other soft tissue infections.Methods: Prospective clinical study analysis of outcome of sixty of patients with soft tissue infections were evaluated based on LRINEC. Based on their LRINEC score, the patients were categorized as low, intermediate and high risk for the onset of necrotizing fasciitis.Results: A total of 60 patients with soft tissue infections were prospectively evaluated and categorized on the basis of LRINEC score 45 patients in low risk category, 7 in Intermediate risk and 8 patients in high risk group. In terms of outcome, all cases (including positive tissue diagnosis cases) in low risk and intermediate risk groups and 2 cases in high risk group were improved with surgical debridement/fasciotomy. The cutoff of LRINEC ≥6 has better sensitivity and specificity in identifying the risk of the patient.Conclusions: LRINEC scoring system has a better positive predictive value in identifying the onset and risk strategizing of necrotizing fasciitis.

scholarly journals Diagnosis and misdiagnosis of necrotizing soft tissue infections: three case reports

Cases Journal ◽  
2008 ◽  
Vol 1 (1) ◽  
Author(s):  
Engelbert Schröpfer ◽  
Stephan Rauthe ◽  
Thomas Meyer
Keyword(s):  
Soft Tissue ◽  
Case Reports ◽  
Soft Tissue Infections ◽  
Necrotizing Soft Tissue Infections
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