Antibiotic-loaded Porous Alumina Ceramic for One-stage Surgery for Chronic Osteomyelitis

Aluminium powder was used as foaming agent in the production of macro-porous alumina ceramic. The porous ceramic material was developed by mixing an appropriate composition of cement, aluminium powder (Al), alumina (Al2O3), calcium oxide (CaO), gypsum (calcium sulphate dehydrate, CaSO4.2H2O), silica powder and deionized water. Different compositions of porous ceramic were produced at 2wt.%, 3wt.% and 4wt.% of aluminium powder. Their mechanical properties and macro-porosity structural of the porous ceramic material were analysed and compared. It is determined that the optimal properties of porous ceramic material were found at 3wt.% of aluminium powder and degraded drastically at 4wt.%. This phenomenon is due to the chemical reaction between the aluminium powder and DI water in which they form aluminium oxide that promotes the strength of the material but at the same time, more pores are created at higher reaction rate between these two fundamental materials.

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Refinements in the one-stage procedure for management of chronic osteomyelitis

Microsurgery ◽

10.1002/micr.1920160906 ◽

1995 ◽

Vol 16 (9) ◽

pp. 606-611 ◽

Cited By ~ 22

Author(s):

Paul J. Guelinckx ◽

Nadja K. Sinsel

Keyword(s):

Chronic Osteomyelitis ◽

One Stage ◽

The One

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Evaluation of porous alumina ceramic implants,

Journal of Dentistry ◽

10.1016/0300-5712(78)90183-5 ◽

1978 ◽

Vol 6 (4) ◽

pp. 358-359

Author(s):

G.A. Smith

Keyword(s):

Porous Alumina ◽

Alumina Ceramic ◽

Ceramic Implants

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Rapid surface microstructuring of porous alumina ceramic using continuous wave Nd:YAG laser

Journal of Materials Processing Technology ◽

10.1016/j.jmatprotec.2008.12.001 ◽

2009 ◽

Vol 209 (10) ◽

pp. 4744-4749 ◽

Cited By ~ 11

Author(s):

Sandip P. Harimkar ◽

Narendra B. Dahotre

Keyword(s):

Nd:Yag Laser ◽

Continuous Wave ◽

Porous Alumina ◽

Alumina Ceramic

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First Sternal Cleft Repair Using a Porous Alumina Ceramic Prosthesis in a 9-Year-Old Child

European Journal of Pediatric Surgery Reports ◽

10.1055/s-0039-1688775 ◽

2019 ◽

Vol 07 (01) ◽

pp. e20-e23

Author(s):

Virginie Fouilloux ◽

François Bertin ◽

Emilie Peltier ◽

Jean-Luc Jouve

Keyword(s):

Porous Alumina ◽

Muscle Flap ◽

Alumina Ceramic ◽

Congenital Defects ◽

Deep Sternal Wound Infection ◽

Sternal Cleft ◽

Good Healing ◽

Rare Congenital Abnormality ◽

Sternal Reconstruction

AbstractSternal cleft is a rare congenital abnormality, often associated with other congenital defects. We present the case of a 9-year-old child with complete sternal cleft, treated with an innovative sternal prosthesis. Surgery was performed to protect the heart and also, as pulsations was visible, leading to serious esthetical concerns, to enhance school integration, which was difficult. The porous alumina device used was initially designed for sternal reconstruction after refractory deep sternal wound infection or carcinoma. Surgery and early follow-up were simple. There was no complication and the follow-up of more than 1 year reveals a good healing without breath discomfort and a correct development of the chest wall. In this rare indication, the alumina ceramic sternal prosthesis offers a reliable alternative to classical methods, such as muscle flap, autogenous tissue transfer, costal homograft, and other prosthetic materials like mesh or synthetic patch.

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Cost-Effectiveness Study of One-Stage Treatment of Chronic Osteomyelitis with Bioactive Glass S53P4

Materials ◽

10.3390/ma12193209 ◽

2019 ◽

Vol 12 (19) ◽

pp. 3209 ◽

Cited By ~ 2

Author(s):

Jan Geurts ◽

Tom van Vugt ◽

Eline Thijssen ◽

Jacobus J. Arts

Keyword(s):

Cost Effectiveness ◽

Clinical Outcome ◽

Bioactive Glass ◽

Chronic Osteomyelitis ◽

Cost Effective ◽

Sensitivity Analyses ◽

Base Case ◽

Control Group ◽

Two Stage ◽

One Stage

This study was set up to evaluate the costs of a one-stage treatment of chronic osteomyelitis using bioactive glass S53P4 versus a two-stage treatment using gentamicin-loaded PMMA beads. Furthermore, a cost-effectiveness analysis was performed from a hospital’s perspective together with the evaluation of clinical outcome. A treatment group (n = 25) receiving one-stage surgery with bioactive glass was retrospectively compared with a two-stage control group (n = 25). An assessment was made of all costs included from first outpatient visit until one year after treatment. Bootstrap simulation and sensitivity analyses were performed. The primary endpoint was cost-effectiveness with clinical outcome as the secondary endpoint. The base case analyses shows dominance of the one-stage treatment with bioactive glass S53P4 due to lower costs and a better clinical outcome. Sensitivity analyses confirm these findings. This study is the first in its kind to show one-stage treatment of chronic osteomyelitis with bioactive glass S53P4 to be cost-effective.

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