Double inversion recovery (DIR) sequences compared to Fluid Attenuation Inversion Recovery (FLAIR) and T2W sequences in evaluation of Multiple sclerosis by magnetic resonance

Aims: The current work aimed to assess the diagnostically value of Magnetic Resonance Imaging (MRI) Double Inversion Recovery (DIR) sequence in diagnosing of multiple sclerosis. Methodology: This study conducted on (42 patients) from the Diagnostic Radiology and Medical Imaging Dep. at Tanta University Hospital in the period from March 2018 to December 2019. Results: In accordance to the total lesions loads, it was found that DIR was higher significantly than T2WI (P-value= 0.003 with a relative gaining of 22%), we found that double inversion recovery (DIR) sequence was higher significantly to FLAIR regarding the number of diagnosed lesions in 3 anatomical areas (Mixed W-GM, cortical and infra-tentorial) with relative gaining of 28%, 85% and 63% respectively. A non-significant change was found among the two sequences regarding peri-ventricular white matter, deep white matter and juxta-cortical lesions detecting. Conclusion: Conventionally MRI has corner-stone roles in diagnosing, characterizing and following-up of multi-sclerosis. Finally, we concluded that DIR can be used as a addition to or even as an alternative for typical T2 and FLAIR. Therefore, we strongly recommend the addition of DIR sequences in the everyday MR protocol of MS cases.

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Brain and deep grey-matter atrophy in relapsing-remitting multiple sclerosis with cortical lesions based on double inversion recovery MRI

10.26226/morressier.5b719e455aff74008ae4c9f6 ◽

2018 ◽

Author(s):

Maria Andrea Parra Corral

Keyword(s):

Multiple Sclerosis ◽

Grey Matter ◽

Inversion Recovery ◽

Double Inversion Recovery ◽

Cortical Lesions ◽

Relapsing Remitting ◽

Deep Grey Matter ◽

Remitting Multiple Sclerosis ◽

Relapsing Remitting Multiple Sclerosis ◽

Grey Matter Atrophy

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Double-inversion recovery with synthetic magnetic resonance: a pilot study for assessing synovitis of the knee joint compared to contrast-enhanced magnetic resonance imaging

European Radiology ◽

10.1007/s00330-018-5800-9 ◽

2018 ◽

Vol 29 (5) ◽

pp. 2573-2580 ◽

Cited By ~ 1

Author(s):

Jisook Yi ◽

Young Han Lee ◽

Ho-Taek Song ◽

Jin-Suck Suh

Keyword(s):

Magnetic Resonance Imaging ◽

Pilot Study ◽

Magnetic Resonance ◽

Knee Joint ◽

Inversion Recovery ◽

Double Inversion Recovery ◽

Resonance Imaging ◽

Contrast Enhanced

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Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla

European Radiology ◽

10.1007/s00330-009-1705-y ◽

2010 ◽

Vol 20 (7) ◽

pp. 1675-1683 ◽

Cited By ~ 108

Author(s):

Birgit Simon ◽

Stephan Schmidt ◽

Carsten Lukas ◽

Jürgen Gieseke ◽

Frank Träber ◽

...

Keyword(s):

Multiple Sclerosis ◽

Mr Imaging ◽

Inversion Recovery ◽

3 Tesla ◽

Double Inversion Recovery ◽

Cortical Lesions ◽

In Vivo Detection

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HLA-DRB1*04:05 allele is associated with intracortical lesions on three-dimensional double inversion recovery images in Japanese patients with multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458517707067 ◽

2017 ◽

Vol 24 (6) ◽

pp. 710-720 ◽

Cited By ~ 9

Author(s):

Koji Shinoda ◽

Takuya Matsushita ◽

Yuri Nakamura ◽

Katsuhisa Masaki ◽

Ryo Yamasaki ◽

...

Keyword(s):

Multiple Sclerosis ◽

Three Dimensional ◽

Multivariate Logistic Regression Analysis ◽

Clinical Information ◽

Japanese Patients ◽

Inversion Recovery ◽

Double Inversion Recovery ◽

Inversion Recovery Imaging ◽

Disability Status ◽

Caucasian Patients

Background: Cortical lesions (CLs) frequently observed in Caucasian patients with multiple sclerosis (MS) contribute to disability. However, it remains unclear whether CLs are associated with clinical features and genetic risk factors, such as HLA-DRB1*15:01 and -DRB1*04:05 in Asian MS patients. Objective: To elucidate the frequency of CLs and their association with HLA-DRB1 and DPB1 alleles in Japanese MS patients. Methods: Three-dimensional double inversion recovery imaging and clinical information were retrospectively obtained from 92 Japanese MS patients. Results: CLs of any type, intracortical lesions (ICLs), and leukocortical lesions (LCLs) were detected in 39.1%, 26.1%, and 28.3% of patients, respectively. MS patients with ICLs had a significantly higher frequency of secondary progression and greater Expanded Disability Status Scale (EDSS) scores than those without ICLs. Similar trends were observed with CLs and LCLs. The number of all three lesion types positively correlated with EDSS scores. The frequency and number of ICLs were significantly higher in HLA-DRB1*15:01 carriers than in HLA-DRB1*15:01 non-carriers, but significantly lower in HLA-DRB1*04:05 carriers than in HLA-DRB1*04:05 non-carriers. Multivariate logistic regression analysis revealed a negative association of HLA-DRB1*04:05 with ICLs. Conclusion: ICLs are associated with greater disease severity in Japanese MS patients and are partly suppressed by the HLA-DRB1*04:05 allele.

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