Serum Uric Acid Could Differentiate Acute Myocardial Infarction and Unstable Angina Pectoris in Hyperuricemic Acute Coronary Syndrome Patients

Objective.More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis-related diseases. However, the plasma levels of IL-37 in patients with acute coronary syndrome (ACS, including unstable angina pectoris and acute myocardial infarction) have yet to be investigated.Methods.Plasma IL-37, IL-18, and IL-18BP levels were measured in 50 patients with stable angina pectoris (SAP), 75 patients with unstable angina pectoris (UAP), 67 patients with acute myocardial infarction (AMI), and 65 control patients.Results.The plasma IL-37, IL-18, and IL-18BP levels were significantly increased in ACS patients compared to SAP and control patients. A correlation analysis showed that the plasma biomarker levels were positively correlated with each other and with the levels of C-reactive protein (CRP),N-terminal probrain natriuretic peptide (NT-proBNP), and left ventricular end-diastolic dimension (LVEDD) but negatively correlated with left ventricular ejection fraction (LVEF). Furthermore, the plasma IL-37, IL-18, and IL-18BP had no correlation with the severity of the coronary artery stenosis.Conclusions.The results indicate that the plasma IL-37 levels are associated with the onset of ACS.

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Level of Serum Uric Acid Along with Other Demographic Parameters in Patients with Acute Coronary Syndrome : A Study of 55 Cases from Chittagong

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v13i2.21070 ◽

2014 ◽

Vol 13 (2) ◽

pp. 55-58

Author(s):

Hasan Murad ◽

Rajiv Dey ◽

Md Atiquel Islam Chowdhury ◽

Hridi Hedayet Ullah ◽

Md Abdur Rouf

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Uric Acid ◽

Unstable Angina ◽

Serum Uric Acid ◽

Troponin I ◽

Elevated Serum ◽

Common Finding ◽

Coronary Syndrome

The association between serum uric acid and ischemic heart disease remains controversial and it has been difficult to identify the specific role of elevated serum uric acid because of its association with established cardiovascular risk factors such as hypertension, diabetes mellitus, hyperlipidaemia and obesity. Our objective was to study the association of serum uric acid level with confirmed cases of Acute Coronary Syndrome i.e. Unstable Angina, Acute Myocardial Infarction(AMI). The study was conducted in Chittagong Medical College (CMC) & University of Science and Technology(USTC) and nearby diagnostic centre. The study was based on Patients with Acute Coronary Syndrome proved by ECG and/or raised serum Troponin I. The aim of the study was to determine the relationship between serum uric acid and Unstable angina or myocardial infacrtion. There were 35% males & 5% females. The mean age of respondent was 50 years and age ranges from 35 to 70 years. In this study 50 cases of diagnosed myocardial infarction were selected and subsequently investigated with ECG, Radiological and Echocardiographic investigations. Increased serum uric acid levels are a common finding in patients with high blood pressure, insulin resistance, obesity and Cardiovascular disease. The clinical findings, chest X-ray and ECG findings of patients with risk factors for myocardial infarction were extensively studied and the findings are consistent with findings stated in textbooks.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i2.21070

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Immature Platelet Fraction (IPF) Levels in Acute Coronary Syndrome (ACS) Patients

International Journal of Research and Review ◽

10.52403/ijrr.20210890 ◽

2021 ◽

Vol 8 (8) ◽

pp. 682-688

Author(s):

Enna Berkah Sari ◽

Nizam Zikri Akbar ◽

Herman Hariman

Keyword(s):

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Angina Pectoris ◽

Unstable Angina ◽

Unstable Angina Pectoris ◽

St Segment Elevation ◽

Coronary Syndrome ◽

Segment Elevation Myocardial Infarction ◽

St Segment ◽

Immature Platelet Fraction

Background: Acute Coronary Syndrome (ACS) is a major cardiovascular problem because it causes high hospital admissions and mortality rates. Acute Coronary Syndrome is divided into 3 (three), namely: unstable angina pectoris (UAP), myocardial infarction without ST segment elevation (NSTEMI), and myocardial infarction with ST segment elevation (STEMI). In addition to changes in biomarkers of heart injury, the platelet index (IPF = immature platelet fraction) will also change the level difference between STEMI with NSTEMI/UAP. Objective: To determine the differences in IPF levels of ACS patients with STEMI and NSTEMI/UAP Method: Observational analytic with cross sectional approach. The subjects of this study were 80 patients who came to the emergency installation of integrated heart center Emergency Room Haji Adam Malik Hospital Medan from May 2019 to September 2019 and was diagnosed with ACS (STEMI or NSTEMI/UAP). The sample in the study was the patient's venous blood and put it in an EDTA tube, then immediately checked the IPF value/level using the automatic hematology analyzer. Patients with heart failure or patients with thrombocytopenia were not included in this study. Results: In this study, the demographic characteristics of the ACS patients based on gender were male 77.5% STEMI and 87.5% NSTEMI/UAP while women 22.5% STEMI and 12.5% NSTEMI/UAP. The results of the STEMI patient's IPF levels Compared with NSTEMI/UAP, the median is 6.2 (3.5-16.8) VS 2.9 (0.7-12) with a p-value of 0.0001. Conclusion: The characteristics of ACS patients based on the results of sex were that there were more men with NSTEMI/UAP than those with STEMI. There was a significant difference in the IPF levels of STEMI with NSTEMI/UAP. Keywords: Immature Platelet Fraction (IPF), Acute Coronary Syndrome (ACS), ST-Segment Elevation Myocardial Infarction (STEMI), Non ST-Segment Elevation Myocardial Infarction (NSTEMI), Unstable Angina Pectoris (UAP).

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Prognostic Usefulness of Serum Uric Acid After Acute Myocardial Infarction (The Japanese Acute Coronary Syndrome Study)

The American Journal of Cardiology ◽

10.1016/j.amjcard.2005.04.007 ◽

2005 ◽

Vol 96 (4) ◽

pp. 489-495 ◽

Cited By ~ 66

Author(s):

Sunao Kojima ◽

Tomohiro Sakamoto ◽

Masaharu Ishihara ◽

Kazuo Kimura ◽

Shunichi Miyazaki ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Coronary Syndrome

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Gambaran kadar asam urat pada pasien sindrom koroner akut di RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2015

e-CliniC ◽

10.35790/ecl.4.2.2016.14462 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Annisa Syahfitri ◽

Victor Joseph ◽

Starry H. Rampengan

Keyword(s):

Myocardial Infarction ◽

Acute Coronary Syndrome ◽

Uric Acid ◽

Angina Pectoris ◽

Serum Uric Acid ◽

Elevated Serum ◽

St Segment Elevation ◽

Coronary Syndrome ◽

Segment Elevation Myocardial Infarction ◽

St Segment

Abstract: Acute coronary syndrome (ACS) is the term for symptoms due to disorder of blood flow inside the coronary arteries. ACS consists of unstable angina pectoris (UAP), non–ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI). One predisposition factor of ACS that is still debated is uric acid. Its role in cardiovascular diseases is assumed due to endothelial disruption caused by elevated serum uric acid. This study was aimed to obtain the profile of uric acid serum in ACS patients at Prof. Dr. R. D. Kandou hospital Manado from January to December 2015. This was a retrospective study with a descriptive observational method using medical record of Prof Dr. R. D. Kandou Hospital Manado. The results showed that there were 97 patients with ACS, including 43 (44.33%) patients with NSTEMI, 43 (44.33%) patients with UAP, and 11 (11.34%) patients with STEMI. Males were more common than females. Most patient were aged 55-65 years old. Elevated serum uric acid was found in 52% of patients, generally in males and NSTEMI cases. More than half of the patients had history of elevated serum uric acid. The most risk factor in the cases were hypertension and smoking.Keywords: description, uric acid, acute coronary syndrome Abstrak: Sindrom koroner akut (SKA) merupakan sekelompok gejala akibat gangguan aliran darah pada arteri koroner. SKA terdiri dari unstable angina pectoris (UAP), infark miokard tanpa elevasi ST (NSTEMI), dan infark miokard dengan elevasi ST (STEMI). Salah satu faktor predisposisi SKA yang hingga kini masih diperdebatkan ialah asam urat. Diduga peran asam urat terhadap penyakit kardiovaskular terletak pada gangguan endotel pembuluh darah yang ditimbulkannya. Penelitian ini bertujuan untuk mengetahui gambaran kadar asam urat pada pasien SKA di RSUP Prof. Dr. R. D. Kandou Manado selama periode Januari-Desember 2015. Jenis penelitian ialah retrospektif dengan metode observasional-deskriptif yang dilaksanakan di Bagian Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian mendapatkan 97 pasien SKA dengan data lengkap, diantaranya 43 kasus (44,33%) NSTEMI, 43 kasus (44,33%) UAP, dan 11 kasus (11,34%) STEMI. Pasien terbanyak terdapat pada laki-laki dan kelompok usia 55-65 tahun. Peningkatan kadar asam urat dijumpai pada 52% pasien, umumnya pada laki-laki dan kasus NSTEMI. Umumnya pasien juga memiliki riwayat asam urat. Faktor risiko terbanyak yang dimiliki ialah hipertensi dan merokok. Kata kunci: deskripsi, asam urat, sindrom koroner akut

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