Leukocytes, C-Reactive Protein and Interleukin-6 in Acute Appendicitis in Children: Diagnostic Value and Association with Histological Findings

2009 ◽  
Vol 0 (In Press) ◽  
Author(s):  
Nesad Hotic ◽  
Elmir Cickusic ◽  
Deso Mesic ◽  
Edin Husaric ◽  
Amir Halilbasic ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Interleukin 6 ◽  
Diagnostic Value ◽  
Histological Findings ◽  
C Reactive Protein ◽  
Reactive Protein

Diagnostic Value of Interleukin-6 and C-Reactive Protein in Acute Appendicitis

Swiss Surgery ◽  
2000 ◽  
Vol 6 (4) ◽  
pp. 169-172 ◽  
Author(s):  
Erkasap ◽  
Ates ◽  
Ustuner ◽  
Sahin ◽  
Yilmaz ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Interleukin 6 ◽  
Iliac Fossa ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Perforated Appendix ◽  
Right Iliac Fossa Pain ◽  
The Mean ◽  
Serum Crp

The aim of this study is prospectively to evaluate the serum C-reactive protein (CRP) and interleukin-6 (IL-6) levels in detection of acute appendicitis in patients with right iliac fossa pain. Data were collected in prospective manner on 102 consecutive patients with right iliac fossa pain. Laparotomy was performed for suspected acute appendicitis for 55 of the 102 patients, of whom 49 patients had appendicitis, 6 patients non-appendicitis (NA), and the other 47 patients had nonspecific abdominal pain (NSAP) and they did not undergo operation. Among those with appendicitis 31 had acute appendix (AA), 8 had gangrenous appendix (GA), and 10 had perforated appendix (PA). The WBC and CRP the mean (SEM) values were significantly different in AA, GA, and PA groups compared with NSAP and NA groups (P < 0.05). Although the mean IL-6 levels were significantly different only in PA group than the others groups (P < 0.05). The sensitivity and specificity of serum CRP measurements were calculated as 96% and 87%, respectively whereas these were 33% and 83% for IL-6 levels for the diagnosis of the acute appendicitis. As a result, measurement of the CRP levels and WBC have an additional diagnostic value on the diagnosis of the acute appendicitis but determination of IL-6 levels which added to the test combination of WBC and CRP, the sensitivity for the diagnosis of the acute appendicitis was not changed whereas the specificity was decreased to 66%.

scholarly journals The diagnostic value of white cell count, C-reactive protein and bilirubin in acute appendicitis and its complications

2013 ◽  
Vol 95 (3) ◽  
pp. 215-221 ◽  
Author(s):  
I G Panagiotopoulou ◽  
D Parashar ◽  
R Lin ◽  
S Antonowicz ◽  
AD Wells ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Diagnostic Accuracy ◽  
Cell Count ◽  
Inflammatory Markers ◽  
White Cell Count ◽  
Perforated Appendicitis ◽  
Diagnostic Value ◽  
White Cell ◽  
C Reactive Protein ◽  
Reactive Protein

Introduction Inflammatory markers such as white cell count (WCC) and C-reactive protein (CRP) and, more recently, bilirubin have been used as adjuncts in the diagnosis of appendicitis. The aim of this study was to determine the diagnostic accuracy of the above markers in acute and perforated appendicitis as well as their value in excluding the condition. Methods A retrospective analysis of 1,169 appendicectomies was performed. Patients were grouped according to histological examination of appendicectomy specimens (normal appendix = NA, acute appendicitis = AA, perforated appendicitis = PA) and preoperative laboratory test results were correlated. Receiver operating characteristic (ROC) curve area analysis (area under the curve [AUC]) was performed to examine diagnostic accuracy. Results ROC analysis of all laboratory variables showed that no independent variable was diagnostic for AA. Good diagnostic accuracy was seen for AA when all variables were combined (WCC/CRP/bilirubin combined AUC: 0.8173). In PA, the median CRP level was significantly higher than that of AA (158mg/l vs 30mg, p<0.0001). CRP also showed the highest sensitivity (100%) and negative predictive value (100%) for PA. CRP had the highest diagnostic accuracy in PA (AUC: 0.9322) and this was increased when it was combined with WCC (AUC: 0.9388). Bilirubin added no diagnostic value in PA. Normal levels of WCC, CRP and bilirubin could not rule out appendicitis. Conclusions CRP provides the highest diagnostic accuracy for PA. Bilirubin did not provide any discriminatory value for AA and its complications. Normal inflammatory markers cannot exclude appendicitis, which remains a clinical diagnosis.

Early detection of severe sepsis in the emergency room: Diagnostic value of plasma C-reactive protein, procalcitonin, and interleukin-6

2011 ◽  
Vol 43 (11-12) ◽  
pp. 883-890 ◽  
Author(s):  
Raija Uusitalo-Seppälä ◽  
Pertti Koskinen ◽  
Aila Leino ◽  
Heikki Peuravuori ◽  
Tero Vahlberg ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Early Detection ◽  
Emergency Room ◽  
Interleukin 6 ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Clinical Significance of Procalcitonin, C-Reactive Protein, and Interleukin-6 in Helping Guide the Antibiotic Use for Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Wen Song ◽  
Yue Wang ◽  
Fengming Tian ◽  
Liang Ge ◽  
Xiaoqian Shang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Interleukin 6 ◽  
Antibiotic Use ◽  
Diagnostic Value ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Obstructive Pulmonary Disease ◽  
Reactive Protein ◽  
Acute Exacerbations ◽  
Antibiotic Group

Background. Currently, standards of antibiotic use in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients are controversial. Objective. The aim of the present study was to analyze the value of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) levels to guide the antibiotic treatment of AECOPD patients. Methods. A total of 371 patients with COPD or AECOPD were included in the study. Clinical and laboratory data were obtained at admission, 325 AECOPD patients and 46 sCOPD patients treated with antibiotics. The receiver operating curve (ROC) was used to evaluate the relationship between CRP, PCT, and IL-6. Results. This study included medical record/case control 1, the COPD group ( n = 46 ) and the AECOPD group ( n = 325 ), and medical record control 2, the nonchanged antibiotic group ( n = 203 ) and the changed antibiotic group ( n = 61 ). In case 1, CRP, PCT, and IL-6 levels in the AECOPD group were higher than that in the control group ( P < 0.05 ), while the result of ROC showed that IL-6 had higher AUC values (0.773) and higher sensitivity (71.7%) than other indicators. The specificity of PCT (93.5%) is higher than other indicators. In case 2, ROC curve results showed that the AUC value of IL-6 (0.771) was slightly higher than PCT and CRP. The sensitivity (85.2%) and specificity (65.5%) of CRP were higher than other indicators. Conclusions. IL-6 and PCT were elevated in AECOPD patients, resulting in a higher diagnostic value for AECOPD. CRP had a higher diagnostic value for antibiotic use in AECOPD patients.

Diagnostic value of resistin and visfatin, in comparison with C-reactive protein, procalcitonin and interleukin-6 in neonatal sepsis

2011 ◽  
Vol 22 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Ferhat Cekmez ◽  
Fuat Emre Canpolat ◽  
Merih Çetinkaya ◽  
Seçil Aydinöz ◽  
Gokhan Aydemir ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Neonatal Sepsis ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein

Diagnostic value of C-reactive protein in acute appendicitis

1994 ◽  
Vol 37 (1) ◽  
pp. 49-51 ◽  
Author(s):  
Eugene Albu ◽  
Barnett M. Miller ◽  
Young Choi ◽  
Sanjiv Lakhanpal ◽  
R. N. Murthy ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein
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