Low-Dose 3D Rotational Angiography in Measuring the Size of Intracranial Aneurysm: In Vitro Feasibility Study Using Aneurysm Phantom

Purpose: Three-dimensional (3D) measurement of intracranial aneurysms is important in planning endovascular treatment, and 3D rotational angiography (RA) is effective in accurate measurement. The purpose of this study was to evaluate the feasibility of low dose 3D RA (5 seconds 0.10 μGy/frame) in measuring an intracranial aneurysm using an in vitro phantom.Materials and Methods: We investigated an <I>in vitro</i> 3D phantom of an intracranial aneurysm with 10 acquisitions of 3D RA with a conventional dose (5 seconds 0.36 μGy/frame) and 10 acquisitions with a low-dose (5 seconds 0.10 μGy/frame). 3D size and neck diameters of the aneurysm were measured and compared between the 2 groups (conventional and low-dose) using noninferiority statistics.Results: The aneurysm measurements were well-correlated between the 2 readers, and noninferiority in the measurement of aneurysmal size of low-dose 3D RA was demonstrated, as the upper margin of the 1-sided 97.5% confidence interval did not cross the pre-defined noninferiority margin of 0.2 mm by the 2 readers.Conclusion: Low-dose (5 seconds 0.10 μGy/frame) cerebral 3D RA is technically feasible and not inferior in in vitro 3D measurement of an intracranial aneurysm. Thus, low-dose 3D RA is promising and needs further evaluation for its clinical utility in the planning of endovascular treatment of an intracranial aneurysm.

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3D Rotational Angiography: Recent Experience in the Evaluation of Cerebral Aneurysms for Treatment

Interventional Neuroradiology ◽

10.1177/159101990000600202 ◽

2000 ◽

Vol 6 (2) ◽

pp. 85-94 ◽

Cited By ~ 13

Author(s):

S. Ishihara ◽

I.B. Ross ◽

M. Piotin ◽

A. Weill ◽

H. Aerts ◽

...

Keyword(s):

Decision Making ◽

Surgical Treatment ◽

Endovascular Treatment ◽

Three Dimensional ◽

Cerebral Aneurysms ◽

Early Experience ◽

Recent Experience ◽

Rotational Angiography ◽

3D Images ◽

3D Rotational Angiography

Three dimensional (3D) reconstruction techniques providing volume rendered 3D images from rotational angiography data now exist. We report the design and early experience with one such system. 237 aneurysms were studied. Information was obtained on the morphology of the aneurysm itself and the vascular architecture in and around the aneurysm. 218 (92%) aneurysms went on to have endovascular treatment. The 3D images provided valuable information on aneurysmal anatomy, including relationships with the parent and adjacent vessels. This technique allowed fast and safe decision-making regarding the feasibility of endovascular or surgical treatment and provided useful information for performing the chosen treatment.

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Image-guided vascular neurosurgery based on three-dimensional rotational angiography

Journal of Neurosurgery ◽

10.3171/jns.2007.106.3.501 ◽

2007 ◽

Vol 106 (3) ◽

pp. 501-506 ◽

Cited By ~ 12

Author(s):

Peter W. A. Willems ◽

Theo Van Walsum ◽

Peter A. Woerdeman ◽

Everine B. Van De Kraats ◽

Gerard A. P. De Kort ◽

...

Keyword(s):

Image Registration ◽

Navigation System ◽

Three Dimensional ◽

Region Of Interest ◽

Small Region ◽

Rotational Angiography ◽

Vascular Tree ◽

Data Set ◽

3D Rotational Angiography ◽

Vascular Neurosurgery

✓Three-dimensional rotational angiography is capable of exquisite visualization of cerebral blood vessels and their pathophysiology. Unfortunately, images obtained using this modality typically show a small region of interest without exterior landmarks to allow patient-to-image registration, precluding their use for neuronavigation purposes. The aim of this study was to find an alternative technique to enable 3D rotational angiography–guided vascular neurosurgery. Three-dimensional rotational angiograms were obtained in an angiographic suite with direct navigation capabilities. After image acquisition, a navigated pointer was used to touch fiducial positions on the patient's head. These positions were located outside the image volume but could nevertheless be transformed into image coordinates and stored in the navigation system. Prior to surgery, the data set was transferred to the navigation system in the operating room, and the same fiducial positions were touched again to complete the patient-to-image registration. This technique was tested on a Perspex phantom representing the cerebral vascular tree and on two patients with an intracranial aneurysm. In both the phantom and patients, the neuronavigation system provided 3D images representing the vascular tree in its correct orientation, that is, the orientation seen by the neurosurgeon through the microscope. In one patient, tissue shift was clearly observed without significant changes in the orientation of the structures. Results in this study demonstrate the feasibility of using 3D rotational angiography data sets for neuronavigation purposes. Determining the benefit of this type of navigation should be the subject of future studies.

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Three-dimensional angiography for radiosurgical treatment planning for arteriovenous malformations

Journal of Neurosurgery ◽

10.3171/jns.2003.98.3.0536 ◽

2003 ◽

Vol 98 (3) ◽

pp. 536-543 ◽

Cited By ~ 33

Author(s):

Federico Colombo ◽

Carlo Cavedon ◽

Paolo Francescon ◽

Leopoldo Casentini ◽

Umberto Fornezza ◽

...

Keyword(s):

Treatment Planning ◽

Imaging Modality ◽

Treatment Plan ◽

Three Dimensional ◽

Ct Scanning ◽

New Method ◽

Rotational Angiography ◽

Content Type ◽

3D Rotational Angiography ◽

Fine Print

Object. Radiosurgical treatment of a cerebral arteriovenous malformation (AVM) requires the precise definition of the nidus of the lesion in stereotactic space. This cannot be accomplished using simple stereotactic angiography, but requires a combination of stereotactic biplanar angiographic images and stereotactic contrast-enhanced computerized tomography (CT) scans. In the present study the authors describe a method in which three-dimensional (3D) rotational angiography is integrated into stereotactic space to aid treatment planning for radiosurgery. Methods. Twenty patients harboring AVMs underwent treatment planning prior to linear accelerator radiosurgery. Planning involved the acquisition of two different data sets, one of which was obtained using the standard method (a combination of biplanar stereotactic angiography with stereotactic CT scanning), and the other, which was procured using a new technique (nonstereotactic 3D rotational angiography combined with stereotactic CT scanning by a procedure of image fusion). The treatment plan that was developed using the new method was compared with that developed using the standard one. For each patient the number of isocenters and the dimension of selected collimators were the same, based on the information supplied in both methods. Target coordinates were modified in only five cases and by a limited amount (mean 0.7 mm, range 0.3–1 mm). Conclusions. The new imaging modality offers an easier and more immediate interpretation of 3D data, while maintaining the same accuracy in target definition as that provided by the standard technique. Moreover, the new method has the advantage of using nonstereotactic 3D angiography, which can be performed at a different site and a different time with respect to the irradiation procedure.

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Reproducibility of image-based computational models of intracranial aneurysm: a comparison between 3D rotational angiography, CT angiography and MR angiography

BioMedical Engineering OnLine ◽

10.1186/s12938-016-0163-4 ◽

2016 ◽

Vol 15 (1) ◽

Cited By ~ 22

Author(s):

Yuan Ren ◽

Guo-Zhong Chen ◽

Zhen Liu ◽

Yan Cai ◽

Guang-Ming Lu ◽

...

Keyword(s):

Intracranial Aneurysm ◽

Ct Angiography ◽

Mr Angiography ◽

Computational Models ◽

Rotational Angiography ◽

3D Rotational Angiography

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A case of successful endovascular treatment of cavernous dural arteriovenous fistula using 3D-rotational angiography

Journal of Neuroendovascular Therapy ◽

10.5797/jnet.2.232 ◽

2008 ◽

Vol 2 (3) ◽

pp. 232-237

Author(s):

Toshio HIGASHI ◽

Ichiro NAKAHARA ◽

Shoji MATSUMOTO ◽

Yasushi IWAMURO ◽

Yoshihiko WATANABE ◽

...

Keyword(s):

Endovascular Treatment ◽

Arteriovenous Fistula ◽

Dural Arteriovenous Fistula ◽

Rotational Angiography ◽

3D Rotational Angiography

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Fusion of Three-dimensional Calcium Rendering with Rotational Angiography to Guide the Treatment of a Giant Intracranial Aneurysm: Technical Case Report

Operative Neurosurgery ◽

10.1227/01.neu.0000193524.98940.bb ◽

2006 ◽

Vol 58 ◽

pp. ONS-E173 ◽

Cited By ~ 1

Author(s):

Daniel A. Hoit ◽

Adel M. Malek

Keyword(s):

Case Report ◽

Intracranial Aneurysm ◽

Three Dimensional ◽

Rotational Angiography ◽

Giant Intracranial Aneurysm

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Combined Environment Simulator for Low-Dose-Rate Radiation and Partial Gravity of Moon and Mars

Life ◽

10.3390/life10110274 ◽

2020 ◽

Vol 10 (11) ◽

pp. 274

Author(s):

Akihisa Takahashi ◽

Sakuya Yamanouchi ◽

Kazuomi Takeuchi ◽

Shogo Takahashi ◽

Mutsumi Tashiro ◽

...

Keyword(s):

Dose Rate ◽

Low Dose ◽

Three Dimensional ◽

Space Radiation ◽

Combined Effects ◽

The Moon ◽

Low Dose Rate ◽

Partial Gravity ◽

Spaceflight Experiments

Deep space exploration by humans has become more realistic, with planned returns to the Moon, travel to Mars, and beyond. Space radiation with a low dose rate would be a constant risk for space travelers. The combined effects of space radiation and partial gravity such as on the Moon and Mars are unknown. The difficulty for such research is that there are no good simulating systems on the ground to investigate these combined effects. To address this knowledge gap, we developed the Simulator of the environments on the Moon and Mars with Neutron irradiation and Gravity change (SwiNG) for in vitro experiments using disposable closed cell culture chambers. The device simulates partial gravity using a centrifuge in a three-dimensional clinostat. Six samples are exposed at once to neutrons at a low dose rate (1 mGy/day) using Californium-252 in the center of the centrifuge. The system is compact including two SwiNG devices in the incubator, one with and one without radiation source, with a cooling function. This simulator is highly convenient for ground-based biological experiments because of limited access to spaceflight experiments. SwiNG can contribute significantly to research on the combined effects of space radiation and partial gravity.

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