Global perspective of treatment failures

Overactive bladder (OAB) is a highly prevalent condition, affecting approximately 18% of adult Canadians. The impact of OAB is substantial, negatively affecting quality of life, sexuality and work productivity. Furthermore, patients with OAB are at increased risk of several other important comorbidities, including mood and anxiety disorders. Despite widespread availability of efficacious treatment, research has shown that OAB remains underdiagnosed and undertreated.

Download Full-text

The impact of age, gender and severity of overactive bladder wet on quality of life, productivity, treatment patterns and satisfaction

Journal of Clinical Urology ◽

10.1177/2051415817710111 ◽

2017 ◽

Vol 10 (6) ◽

pp. 513-522 ◽

Cited By ~ 1

Author(s):

SM Lloyd ◽

G Crawford ◽

P McSkimming ◽

M Grifi ◽

TJ Greenwell ◽

...

Keyword(s):

Quality Of Life ◽

Overactive Bladder ◽

Treatment Satisfaction ◽

Online Survey ◽

Work Productivity ◽

Treatment Patterns ◽

King’S Health Questionnaire ◽

And Gender ◽

The Impact

Objective: The objective of this article is to determine the impact of idiopathic overactive bladder wet (OAB wet) severity, age and gender on health-related quality of life (HRQoL), productivity, treatment patterns and treatment satisfaction. Materials and methods: A prospective, cross-sectional online survey of adults in the United Kingdom was performed to screen for self-reported symptoms of OAB wet. Respondents completed the King’s Health Questionnaire or the Incontinence Quality of Life, as well as the Euroqol 5D, and the Work Productivity and Activity Impairment Specific Health Problem questionnaire, and questions pertaining to distress, treatment and treatment satisfaction. Results: A total of 249 of 1126 respondents (22.1%) met the criteria for OAB wet. Respondents with moderate/severe OAB wet and all women experienced significantly worse HRQoL and work productivity than those with mild symptoms and all men, respectively. Among all OAB wet responders, 62.7% were receiving treatment for their condition, predominantly pads (40.2%); only 1.6% were receiving specialised treatment. Nearly one-half (44.6%) were somewhat or completely dissatisfied with their current treatment. Conclusion: In individuals with OAB wet, severity and gender negatively impact HRQoL and work productivity. A substantial proportion of OAB wet individuals were untreated, and low treatment satisfaction was reported in those receiving treatment. Treatment was generally conservative.

Download Full-text

Faculty Opinions recommendation of The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1157321.617460 ◽

2009 ◽

Author(s):

Guido Barbagli ◽

Massimo Lazzeri

Keyword(s):

Quality Of Life ◽

Lower Urinary Tract ◽

Work Productivity ◽

Well Being ◽

Men And Women ◽

Urinary Tract Symptoms ◽

The Impact ◽

Life Work ◽

Lower Urinary

Download Full-text

AB0727 WORK OUTCOMES AND ASSOCIATED FACTORS IN ANKYLOSING SPONDYLITIS PATIENTS IN CHINA

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.1650 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1658.1-1658

Author(s):

L. Tu ◽

Y. Xie ◽

Q. Lv ◽

M. Yang ◽

Z. Liao ◽

...

Keyword(s):

Quality Of Life ◽

Ankylosing Spondylitis ◽

Disease Duration ◽

Productivity Loss ◽

Work Productivity ◽

Work Outcomes ◽

Activity Impairment ◽

Factors Associated ◽

The Impact

Background:Poorer work productivity due to pain and functional impairment is commonly seen in ankylosing spondylitis (AS) patients, which may contribute to huge social economic burden. However, data about work outcomes and associated factors in Chinese AS patients were barely reported.Objectives:To assess work outcomes and identify factors associated with poor work productivity in patients with AS in China.Methods:A cross-sectional study was conducted in China. Adult patients (aged ≥ 18 years) fulfilled the 1984 New York modified criteria of AS were enrolled from rheumatology center from Jan 2017 to Aug 2017. All participants completed questionnaires about socio-demographic characteristics, disease characteristics, quality of life and the Work productivity and activity impairment questionnaire in AS (WPAI:SpA) to accesses the impact of chronic health conditions on job performance and productivity. Factors associated with work outcomes were evaluated.Results:A total of 91 patients with AS were included: 87.8% males, 78.02% employed, mean age and disease duration of 30 and 10 years respectively. The mean (SD) activity impairment of all patients was 48.57% (22.02%). For patients with employed work, mean (SD) absenteeism, presenteeism and work productivity loss were 10.22% (19.44%), 43.86% (22.48%) and 47.92% (25.81%) respectively. In multivariable analysis, activity impairment was associated with Bath Ankylosing Spondylitis Functional Index (BASFI) (P<0.01) and Ankylosing Spondylitis Quality of Life (ASQoL) (P<0.01). Absenteeism was associated with disease duration (P=0.03). Presenteeism was associated with disease duration (P=0.04), BASFI (P<0.01) and ASQoL (P<0.01). Work productivity loss was associated with BASFI (P<0.01) and ASQoL (P<0.01).Conclusion:Longer disease duration, reduced physical function and poorer quality of life are associated with reduced work productivity in Chinese AS patients.References:[1]Boonen A, van der Heijde D, Landewe R, Spoorenberg A, Schouten H, Rutten-van Molken M, et al. Work status and productivity costs due to ankylosing spondylitis: comparison of three European countries. Annals of the rheumatic diseases. 2002;61(5):429-37.[2]Martindale J, Shukla R, Goodacre J. The impact of ankylosing spondylitis/axial spondyloarthritis on work productivity. Best Pract Res Clin Rheumatol. 2015;29(3):512-23.[3]Castillo-Ortiz JD, Ramiro S, Landewe R, van der Heijde D, Dougados M, van den Bosch F, et al. Work Outcome in Patients With Ankylosing Spondylitis: Results From a 12-Year Followup of an International Study. Arthritis Care Res (Hoboken). 2016;68(4):544-52.[4]Sag S, Nas K, Sag MS, Tekeoglu I, Kamanli A. Relationship of work disability between the disease activity, depression and quality of life in patients with ankylosing spondylitis. J Back Musculoskelet Rehabil. 2018;31(3):499-505.[5]Goh Y, Kwan YH, Leung YY, Fong W, Cheung PP. A cross-sectional study on factors associated with poor work outcomes in patients with axial spondyloarthritis in Singapore. Int J Rheum Dis. 2019;22(11):2001-8.Disclosure of Interests:None declared

Download Full-text

The impact of bowel management on the quality of life in children with spina bifida with overactive bladder and detrusor sphincter dyssynergia

Journal of Pediatric Urology ◽

10.1016/j.jpurol.2019.05.005 ◽

2019 ◽

Vol 15 (5) ◽

pp. 457-466 ◽

Cited By ~ 3

Author(s):

Z. Radojicic ◽

S. Milivojevic ◽

J.M. Lazovic ◽

S. Becanovic ◽

I. Korićanac ◽

...

Keyword(s):

Quality Of Life ◽

Spina Bifida ◽

Overactive Bladder ◽

Bowel Management ◽

Detrusor Sphincter Dyssynergia ◽

The Impact

Download Full-text

Loss of Work Productivity and Quality of Life in Patients With Autoimmune Bullous Dermatoses

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475415582317 ◽

2015 ◽

Vol 19 (6) ◽

pp. 546-554 ◽

Cited By ~ 6

Author(s):

K. Heelan ◽

S. L. Hitzig ◽

S. Knowles ◽

A. M. Drucker ◽

N. Mittmann ◽

...

Keyword(s):

Quality Of Life ◽

Dermatology Life Quality Index ◽

Quality Index ◽

Life Quality ◽

Work Productivity ◽

Activity Impairment ◽

Work Impairment ◽

Life Quality Index ◽

The Impact

Background: Little is known about quality of life and work productivity in autoimmune bullous dermatoses (AIBDs). Objective: To determine the impact of AIBDs on quality of life and work productivity. Methods: An observational cross-sectional study took place between February and May 2013 at an AIBD tertiary referral centre. Ninety-four patients were included. All participants completed the Dermatology Life Quality Index and the Work Productivity and Activity Impairment–Specific Health Problem questionnaires. Results: Responders to treatment had less impairment ( P < .001) than nonresponders. Patients with severe AIBD had significantly more impairment that those with mild ( P < .001) and moderate ( P = .002) AIBD. Greater impairment was associated with higher percentage of work missed. Those with a higher Dermatology Life Quality Index score had greater work impairment and overall activity impairment ( P = .041, P = .024). Nonresponders had increased impairment while working ( P < .001), overall work impairment ( P < .001), and activity impairment ( P < .001). Severely affected patients had worse impairment in all Work Productivity and Activity Impairment Questionnaire domains. Conclusions: AIBD has the potential to be a large burden on ability to work and quality of life. Larger studies are needed to clarify how these domains change over time and whether or not they improve with treatment.

Download Full-text

072 The Impact of Vaginal Dryness on Quality of Life and Work Productivity

Journal of Sexual Medicine ◽

10.1016/j.jsxm.2020.04.308 ◽

2020 ◽

Vol 17 (7) ◽

pp. S254-S255

Author(s):

A. Smith ◽

N. Fawkes ◽

S. Hood ◽

E. Spittle ◽

T. Ogundimu

Keyword(s):

Quality Of Life ◽

Work Productivity ◽

Vaginal Dryness ◽

The Impact

Download Full-text

O26 Non-serious infections in patients with RA: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Rheumatology ◽

10.1093/rheumatology/keaa110.025 ◽

2020 ◽

Vol 59 (Supplement_2) ◽

Author(s):

Katie Bechman ◽

Kapil Halai ◽

Sam Norton ◽

Andrew P Cope ◽

Kimme L Hyrich ◽

...

Keyword(s):

Quality Of Life ◽

Rheumatoid Arthritis ◽

British Society ◽

Tnf Inhibitor ◽

Drug Survival ◽

Increased Risk ◽

Serious Infections ◽

The Impact ◽

Biologics Register

Abstract Background Patients with rheumatoid arthritis (RA) are at an increased risk of infection. Most attention has been given to serious infections, but these are the tip of the iceberg. Non-serious infections (NSI) are far more frequent, and although not life-threatening, have potential to impact treatment outcomes (drug survival) and quality of life. Our objective was to describe frequency of NSI and compare incidence of NSI by biologic drug within the British Society for Rheumatology Biologics Register (BSRBR-RA). Methods The BSRBR-RA is a prospective observational cohort study. NSI was identified as not requiring hospitalisation, intravenous therapy or leading to disability or death. Infections were captured from clinician questionnaires and patient diaries. Individuals were considered ‘at risk’ from the date of commencing biologic treatment for 3 years. Drug exposure was defined by agent; TNF inhibitor, IL-6 inhibitor, anti-CD20 or csDMARD only. To account for a high frequency of events, a multiple-failure Cox model was used. Multivariable adjustment included age, gender, DAS28-ESR, HAQ-DI, disease duration, smoking, steroid usage, year recruited to BSRBR-RA, line of biologic therapy and cumulative infection number. Results There were 17,304 NSI in 10,099 patients, with an event rate of 27.0 per year (95% CI 26.6 to 27.4). Increasing age, female gender, comorbidity burden, corticosteroid therapy, DAS28 and HAQ-DI were associated with an increased risk of NSI. The rate of NSI was numerically lowest with csDMARDs. Compared to TNFi, IL-6 inhibitor had a higher risk of NSI, whilst the csDMARD cohort had a lower risk. Between the TNFi agents, adalimumab had a higher risk than etanercept (Table 1). Conclusion These results confirm that NSI is a frequent occurrence for patients, which historically has received little attention in research literature. The data suggest biologics increase the risk of NSI, especially IL-6 inhibition. Whilst unmeasured confounding must be considered, the magnitude of effects are large and it seems likely that a causal link between targeted immunosuppression and NSI risk exists. Further research is needed to understand the impact of NSI on clinical outcomes including drug survival and quality of life. Disclosures K. Bechman: None. K. Halai: None. S. Norton: None. A.P. Cope: None. K.L. Hyrich: Honoraria; AbbVie paid to the institution and grant income from Pfizer and Bristol-Myers Squibb for activities outside of this work. J.B. Galloway: Honoraria; for speaking or attending conferences from AbbVie, Bristol-Myers Squibb, Celgene, Janssen, Pfizer and Union Chimique Belge.

Download Full-text

Lack of application of the European Work Time Directive: effects on workload, work satisfaction and burnout among Italian physicians

Italian Journal of Medicine ◽

10.4081/itjm.2017.714 ◽

2017 ◽

Vol 11 (2) ◽

pp. 159

Author(s):

Paola Gnerre ◽

Domenico Montemurro ◽

Andrea P. Rossi ◽

Costantino Troise ◽

Carlo Palermo ◽

...

Keyword(s):

Quality Of Life ◽

Work Conditions ◽

Public Hospitals ◽

Burnout Syndrome ◽

Negative Consequences ◽

Work Time ◽

Increased Risk ◽

Wide Range ◽

The Impact

The Italian Parliament has excluded hospital physicians from the application of the European Work Time Directive (EWTD), which imposes a maximum workweek of 48 h and compulsory resting periods. This resulted in extended and excessive work time for the category. This paper is aimed at evaluating the impact of this legislation gap, by assessing the presence of excessive work-related stress and risk for burnout syndrome among Italian physicians working in public hospitals. This observational study is based on an on-line survey conducted on a sample of 1925 Italian doctors (covering a wide range of age, work experience and contractual positions) from October 2014 to February 2015. The questionnaire included 30 questions concerning their personal and professional life (<em>e.g</em>., assessment of workloads, number of uncomfortable or extra shifts, unused days-off, <em>etc</em>.). On the basis of the results, it can be inferred that the average Italian doctor working in public hospitals is under considerable stress at work with negative consequences on his health. He is exposed to high risk of suffering from sleep disorders and cardiovascular diseases (due to the lack of time for private practice and eating regular meals). Overall, his perception is that his job worsens his quality of life. This study shows the relevance of the risk of burnout among Italian physicians employed in public hospitals due to severe workload and work conditions. The resulting impact on the quality of care and the significant cost involved - both in human and economic terms - calls for significant emergency measures by the Italian health work organization. An important increase and prolonged working time is associated with a worsening of the objective cognitive performance and an increase of clinical risk, but also to an increased risk of diseases for operators and of the burnout syndrome. Our survey shows that lack of application of the EWTD has adverse effects on the quality of life and performance of Italian doctors. Failure to respond by all Italian doctors is the greatest limitation of our survey.

Download Full-text