Formulation of Mupirocin Adsorbed Silver Nanoparticle with Antibiofilm Agents for Enhancing Antibacterial Activity

Abstract Background The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategies must take into account the existence of extracellular polymeric substances, which obstruct the diffusion of antibiofilm agents and assists in the maintenance of a well-defended microbial community. Within this context, nanoparticles have been studied for their drug delivery efficacy and easily customised surface. Nevertheless, there usually is a requirement for nanocarriers to be used in association with an antimicrobial agent; the intrinsically antimicrobial nanoparticles are most often made of metals or metal oxides, which is not ideal from ecological and biomedical perspectives. Based on this, the use of polymeric micelles as nanocarriers is appealing as they can be easily prepared using biodegradable organic materials. Results In the present work, micelles comprised of poly(lactic-co-glycolic acid) and dextran are prepared and then functionalised with curcumin. The effect of the functionalisation in the micelle’s physical properties was elucidated, and the antibacterial and antibiofilm activities were assessed for the prepared polymeric nanoparticles against Pseudomonas spp. cells and biofilms. It was found that the nanoparticles have good penetration into the biofilms, which resulted in enhanced antibacterial activity of the conjugated micelles when compared to free curcumin. Furthermore, the curcumin-functionalised micelles were efficient at disrupting mature biofilms and demonstrated antibacterial activity towards biofilm-embedded cells. Conclusion Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp. strains that have the potential to be further exploited to deliver a secondary bioactive molecule within its core. Graphic Abstract

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Production of putrescine-capped stable silver nanoparticle: its characterization and antibacterial activity against multidrug-resistant bacterial strains

Applied Nanoscience ◽

10.1007/s13204-016-0528-9 ◽

2016 ◽

Vol 6 (8) ◽

pp. 1137-1147 ◽

Cited By ~ 2

Author(s):

Saswati Saha ◽

Bhaskar Gupta ◽

Kamala Gupta ◽

Mahua Ghosh Chaudhuri

Keyword(s):

Antibacterial Activity ◽

Silver Nanoparticle ◽

Multidrug Resistant ◽

Bacterial Strains

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Synthesis and characterization of silver nanoparticle-modified TiO2 powder: photocatalytic properties and antibacterial activity

Molecular Crystals and Liquid Crystals ◽

10.1080/15421406.2021.1905278 ◽

2021 ◽

Vol 721 (1) ◽

pp. 86-98

Author(s):

V. I. Vorobyova ◽

S. V. Nahirniak ◽

G. S. Vasyliev ◽

T. A. Dontsova

Keyword(s):

Antibacterial Activity ◽

Silver Nanoparticle ◽

Photocatalytic Properties ◽

Synthesis And Characterization ◽

Tio2 Powder

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In-situ synthesis and characterization of silver nanoparticle decorated cotton knitted fabric for antibacterial activity and improved dyeing performance

SN Applied Sciences ◽

10.1007/s42452-018-0068-x ◽

2018 ◽

Vol 1 (1) ◽

Cited By ~ 2

Author(s):

Imana Shahrin Tania ◽

Mohammad Ali ◽

Md. Shafiul Azam

Keyword(s):

Antibacterial Activity ◽

Silver Nanoparticle ◽

In Situ Synthesis ◽

Synthesis And Characterization ◽

Knitted Fabric ◽

Dyeing Performance ◽

Cotton Knitted Fabric

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Facile fabrication of Tl4HgI6 nanostructures as a novel antibacterial and antibiofilm agents

10.21203/rs.3.rs-101144/v1 ◽

2020 ◽

Author(s):

Maryam Karami ◽

Mojgan Ghanbari ◽

Omid Amiri ◽

MASOUD SALAVATI-NIASARI ◽

Somaye Rashki

Keyword(s):

Raman Spectroscopy ◽

Antibacterial Activity ◽

Bactericidal Activity ◽

Stoichiometric Ratio ◽

Raman Spectrometry ◽

Gram Negative ◽

Biofilm Production ◽

Facile Fabrication ◽

Antibiofilm Agents ◽

The Impact

Abstract In the present study, Tl4HgI6 nanostructures have been successfully fabricated through a simple precipitation route. The impact of TlI stoichiometric ratio to HgI2, and kind of surfactants was explored on purity, structure, and shape of samples. The as-fabricated Tl4HgI6 was characterized via XRD, EDX, FESEM, TEM, HRTEM, and Raman spectroscopy. Raman spectrometry corroborated the XRD outcomes, and revealed that the Tl4HgI6 nanoparticles were successfully fabricated. The structure, shape, and scale of the products were studied through FESEM images. It was observed that different factors have a notable aspect on the morphology and size of the products. The maximum antibacterial activity of Tl4HgI6 was perceived against S. aureus, E.coli and M. catarils. These outcomes demonstrate that Tl4HgI6 displays efficient bactericidal activity against Gram-positive and Gram-negative microorganisms. The anti-biofilm activity revealed that the best reduction of biofilm was recognized in higher Tl4HgI6 concentrations (2×MIC). Tl4HgI6 at 2×MIC concentration inhibits biofilm production by S. aureus and E. feacalis with an inhibition percentage of 95% and 90%, respectively.

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