scholarly journals Production of putrescine-capped stable silver nanoparticle: its characterization and antibacterial activity against multidrug-resistant bacterial strains

2016 ◽  
Vol 6 (8) ◽  
pp. 1137-1147 ◽  
Author(s):  
Saswati Saha ◽  
Bhaskar Gupta ◽  
Kamala Gupta ◽  
Mahua Ghosh Chaudhuri
Keyword(s):  
Antibacterial Activity ◽  
Silver Nanoparticle ◽  
Multidrug Resistant ◽  
Bacterial Strains

scholarly journals Production of a New Thiopeptide Antibiotic, TP-1161, by a Marine Nocardiopsis Species

2010 ◽  
Vol 76 (15) ◽  
pp. 4969-4976 ◽  
Author(s):  
Kerstin Engelhardt ◽  
Kristin F. Degnes ◽  
Michael Kemmler ◽  
Harald Bredholt ◽  
Espen Fj�rvik ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Molecular Taxonomy ◽  
Multidrug Resistant ◽  
Peptide Antibiotic ◽  
Indicator Organisms ◽  
Bacterial Strains ◽  
Pcr Screening ◽  
Vancomycin Resistant ◽  
Antibacterial And Antifungal

ABSTRACT Twenty-seven marine sediment- and sponge-derived actinomycetes with a preference for or dependence on seawater for growth were classified at the genus level using molecular taxonomy. Their potential to produce bioactive secondary metabolites was analyzed by PCR screening for genes involved in polyketide and nonribosomal peptide antibiotic synthesis. Using microwell cultures, conditions for the production of antibacterial and antifungal compounds were identified for 15 of the 27 isolates subjected to this screening. Nine of the 15 active extracts were also active against multiresistant Gram-positive bacterial and/or fungal indicator organisms, including vancomycin-resistant Enterococcus faecium and multidrug-resistant Candida albicans. Activity-guided fractionation of fermentation extracts of isolate TFS65-07, showing strong antibacterial activity and classified as a Nocardiopsis species, allowed the identification and purification of the active compound. Structure elucidation revealed this compound to be a new thiopeptide antibiotic with a rare aminoacetone moiety. The in vitro antibacterial activity of this thiopeptide, designated TP-1161, against a panel of bacterial strains was determined.

scholarly journals Chemical Composition, Antioxidant and Antibacterial Activity of Bunium persicum, Eucalyptus globulus, and Rose Water on Multidrug-Resistant Listeria Species

2018 ◽  
Vol 23 ◽  
pp. 2515690X1775131 ◽  
Author(s):  
Farhad Sharafati Chaleshtori ◽  
Mohamad Saholi ◽  
Reza Sharafati Chaleshtori
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Eucalyptus Globulus ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
Antioxidant Power ◽  
Listeria Species ◽  
Bunium Persicum

This research was aimed at investigating the antioxidant and antibacterial activity of Bunium persicum, Eucalyptus globulus, and rose water on multidrug-resistant Listeria species. The antibiotic resistance of Listeria spp obtained from seafood samples were determined by the Kirby-Bauer method. The antioxidant and antibacterial activity of the essential oils and extracts were evaluated using ferric reducing antioxidant power and microdilution methods, respectively. A total 2 samples (1.88%) were positive for Listeria spp. L monocytogenes was found to be resistant to ampicillin, amoxicillin/clavulanic acid, penicillin, vancomycin, and kanamycin. B persicum essential oil showed the greatest antioxidant activity (248.56 ± 1.09 µM Fe2+/g). The E globulus essential oil showed consistently strong antimicrobial activity against L monocytogenes and L grayi, while rose water showed no antimicrobial activity against any of the tested bacterial strains. The results showed that after adding the B persicum and E globulus essential oils to bacteria, the cell components’ release increased significantly.

Antibacterial activity and action mode of Cu(I) and Cu(II) complexes with phosphines derived from fluoroquinolone against clinical and multidrug-resistant bacterial strains

2020 ◽  
Vol 210 ◽  
pp. 111124 ◽  
Author(s):  
Katarzyna Guz-Regner ◽  
Urszula Katarzyna Komarnicka ◽  
Bożena Futoma-Kołoch ◽  
Maciej Wernecki ◽  
Magdalena Cal ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
Action Mode

scholarly journals Antibacterial Activity and Physicochemical Properties of Florally Diversified Bangladeshi Honeys

2018 ◽  
Vol 33 (1-2) ◽  
pp. 5-9 ◽  
Author(s):  
Roushney Fatima Mukti ◽  
Md Miraj Kobad Chowdhury ◽  
Md Ausrafuggaman Nahid ◽  
Md Mizanur Rahaman ◽  
M Aftab Uddin
Keyword(s):  
Ascorbic Acid ◽  
Antibacterial Activity ◽  
Physicochemical Properties ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
Total Antioxidant ◽  
Phenolics Content

Seven florally diversified Bangladeshi honey samples were assessed for their physicochemical properties as well as their antibiogram profile on different human pathogenic bacterial strains. The average density, total protein content, ascorbic acid content, total phenolics content and the total antioxidant capacity of these honeys were determined as 1.50±0.09 g/ml, 5.63±1.56 mg/g, 91.87±22.16 mg/g, 571.04±289.02 mg gallic acid equivalent/gram, and 320.74±55.06 mg ascorbic acid equivalent/gram of samples, respectively. A significant correlation between the phenolics content and the total antioxidant capacity was observed in commercially available honey samples. However, the natural honey samples showed the best antibacterial activity against different pathogenic multidrug-resistant bacterial strains. Significant antibacterial activities were observed against Klebsiella pneumoniae, Salmonella typhi, Micrococcus luteus, Pseudomonas spp. and Enterobacter spp. and moderate antibacterial activities was observed on Shigella boydii, Bacillus cereus, Bacillus megaterium, and Bacillus subtilis. The antibacterial activity was correlated with the total antioxidant capacity. This study suggested that the Bangladeshi multifloral honeys have clinical potential against multidrug-resistant pathogenic bacterial strains. Bangladesh J Microbiol, Volume 33, Number 1-2, June-Dec 2016, pp 5-9

scholarly journals Metabolic profiling and antibacterial activity of Eryngium pristis Cham. & Schltdl. - prospecting for its use in the treatment of bacterial infections

2021 ◽  
Vol 5 (1) ◽  
pp. 020-028
Author(s):  
Fernandes Laura Silva ◽  
da Costa Ygor Ferreira Garcia ◽  
de Bessa Martha Eunice ◽  
Ferreira Adriana Lucia Pires ◽  
do Amaral Corrêa José Otávio ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Bioactive Compounds ◽  
Metabolic Profile ◽  
Bacterial Infections ◽  
Ethanolic Extract ◽  
Multidrug Resistant ◽  
Gas Chromatography Mass Spectrometry ◽  
Resistant Bacteria ◽  
Bacterial Strains ◽  
New Antibiotics

Morbidity and mortality of the infected patients by multidrug-resistant bacteria have increased, emphasizing the urgency of fight for the discovery of new innovative antibiotics. In this sense, natural products emerge as valuable sources of bioactive compounds. Among the biodiversity, Eryngium pristis Cham. & Schltdl. (Apiaceae Lindl.) is traditionally used to treat thrush and ulcers of throat and mouth, as diuretic and emmenagogue, but scarcely known as an antimicrobial agent. With this context in mind, the goals of this study were to investigate the metabolic profile and the antibacterial activity of ethanolic extract (EE-Ep) and hexane (HF-Ep), dichloromethane (DF-Ep), ethyl acetate (EAF-Ep) and butanol (BF-Ep) fractions from E. pristis leaves. Gas Chromatography-Mass Spectrometry (GC-MS) was performed to stablish the metabolic profile and revealed the presence of 12 and 14 compounds in EAF-Ep and HF-Ep, respectively. β-selinene, spathulenol, globulol, 2-methoxy-4-vinylphenol, α-amyrin, β-amyrin, and lupeol derivative were some of phytochemicals identified. The antibacterial activity was determined by Minimal Inhibitory Concentration (MIC) using the broth micro-dilution against eight ATCC® and five methicillin-resistant Staphylococcus aureus (MRSA) clinical strains. HF-Ep was the most effective (MIC ≤ 5,000 µg/µL), being active against the largest part of tested Gram-positive and Gram-negative bacterial strains, including MRSA, with exception of Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 9027) and (ATCC 27853). These results suggest that E. pristis is a natural source of bioactive compounds for the search of new antibiotics which can be an interesting therapeutic approach to recover patients mainly infected by MRSA strains.

scholarly journals CHLOROFORM FRACTION OF PARKIA JAVANICA BARK POSSESSES ANTIBACTERIAL ACTIVITY AGAINST MULTIDRUG RESISTANT GRAM NEGATIVE BACTERIA PREDOMINANTLY FOUND IN SKIN WOUND

2018 ◽  
Vol 8 (5) ◽  
pp. 184-189
Author(s):  
S Saha ◽  
P Karmakar ◽  
Samir Kumar Sil
Keyword(s):  
Antibacterial Activity ◽  
Cell Damage ◽  
Multidrug Resistant ◽  
Skin Wound ◽  
Lag Phase ◽  
Klebsiella Pneumonia ◽  
Chloroform Fraction ◽  
Bacterial Strains ◽  
Gram Negative ◽  
Antimicrobial Substances

Aim: To evaluate the antibacterial activity of Parkia javanica against gram negative MDR bacterial strains which are predominantly found in skin wound. Methods: The 5 different solvent fractions of Parkia javanica were screened for antibacterial activity against gram negative multi drug resistant bacterial strains namely Enterobacter aerugenes, Pseudomonas aeruginosa and Klebsiella pneumonia by serial dilution technique. Growth kinetics study was performed and percentage of ROS production was measured by NBT reduction assay. Results: The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were obtained with a range of IC100 0.08-0.31 mg/ml in case of MDR bacterial strains. The lag phase of all extract treated bacteria is extended compared to untreated cells. The normalized % of ROS is increased in presence of Parkia javanica extract. Conclusions: This study suggests that, chloroform fraction of Parkia javanica possesses promising antimicrobial substances which are having activity against MDR bacterial strains and ROS induced bacterial cell damage could be the possible mediator of its antimicrobial activity. Keywords:   Parkia javanica, antibacterial activity, MDR bacterial strains, growth curve, ROS.

scholarly journals Antibacterial Activity Against Multidrug-Resistant Staphylococcus aureus and in Silico Evaluation of MepA Efflux Pump by Cinnamaldehyde Chalcone

2021 ◽  
Vol 12 (6) ◽  
pp. 7523-7531
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Natural Products ◽  
Efflux Pump ◽  
Competitive Inhibitor ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
Efflux Pump Inhibition ◽  
Phytochemical Studies

Phytochemical studies on Croton species have identified the presence of secondary metabolites responsible for a wide variety of pharmacological activities, among them antimicrobial activity. Research for new substances with antimicrobial activity derived from natural products can give a major contribution to human health worldwide by finding more efficient and fewer toxic formulas in the race against pathogenic microorganisms' resistance. Among bacterial pathogens, Staphylococcus aureus species, despite being present in the skin and nasal mucosa, can cause many infections and diseases. These opportunists reach debilitated people in hospitals and are challenging to treat. Here, we performed the structural characterization, determination of antibiotic activity, and MepA efflux pump inhibition potential against S. aureus of the chalcone (2E, 4E) -1- (2-hydroxy-3,4,6-trimethoxyphenyl)-5-phenylpenta-2,4-dien-1-one, derived from natural products 2-hydroxy-3,4,6-trimethoxyacetophenone isolated from Croton anisodontus and cinnamaldehyde. The chalcone was synthesized by the Claisen-Schmidt condensation. In addition, microbiological tests were performed to investigate the antibacterial activity, modulator potential, and efflux pump inhibition against the S. aureus multi-resistant strains. MIC values obtained to chalcone were not clinically relevant (MIC ≥ 1024 µg/mL). However, chalcone hampers the binding of the antibiotic to the binding site of the MepA efflux pump. It acts as a competitive inhibitor, being expelled from the bacteria in place of the antibiotic and potentiating ciprofloxacin's action against multidrug-resistant bacterial strains of K2068. Therefore, chalcone can be used as a base for substance design with antibiotic modifying activity.

scholarly journals Short Communication: Antibacterial activity of certain Saudi Arabian medicinal plants used in folk medicine against different groups of bacteria

2017 ◽  
Vol 9 (4) ◽  
pp. 392-395
Author(s):  
ABDULLAH A. AL-GHANAYEM ◽  
SANAD M. AL SOBEAI ◽  
MOHAMMED S. ALHUSSAINI ◽  
BABU JOSEPH ◽  
ABDULMONEIM MOHAMMAD SAADABI
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Folk Medicine ◽  
Saudi Arabian ◽  
Multidrug Resistant ◽  
Diffusion Method ◽  
Calotropis Procera ◽  
Dilution Method ◽  
Bacterial Strains ◽  
Gram Positive

Al-Ghanayem AA, Al Sobeai SM, Alhussaini MS, Joseph B, Saadabi AM. 2017. Antibacterial activity of certain Saudi Arabian medicinal plants used in folk medicine against different groups of bacteria. Nusantara Bioscience 9: 392-395. Medicinal plants from Saudi Arabia has been used in folk medicine for treatment of many diseases. The present research is on medicinal plants, which are locally available such as Acacia ehrenbergiana (Arabic: Salam) (Fabaceae), Calotropis procera (Arabic: Ausher) (Apocynaceae), Haloxylon salicornicum (Arabic: Rimth) (Amaranthaceae), Panicum turgidum (Arabic: Thuman) (Poaceae), Tamarix arabica (Arabic: Athal) (Tamaricaceae), Rhazya stricta (Arabic: Harmal) (Apocynaceae) Rumex vesicarius (Arabic: Humeid) (Polygonaceae) for antimicrobial activity by agar well diffusion method. Minimum Inhibitory Concentration (MIC) has been determined by broth micro dilution method. A. ehrenbergiana was active against Klebsiella pneumoniae. R. vesicarius and T. arabica showed antibacterial activity against Proteus vulgaris. C. procera showed a moderate inhibitory activity against the bacterial pathogens tested. H. salicornicum extract was more effective towards Gram-positive bacteria. However, other extracts such as P. turgidum and R. stricta were less active against both Gram-positive and negative bacteria tested. The results will be helpful in discovering new phytochemical components with antibacterial activity that can be used against multidrug-resistant bacterial strains.

scholarly journals ANTIBACTERIAL ACTIVITY OF FOMITOPSIS BETULINA CULTURAL LIQUID

2019 ◽  
Vol 6 ◽  
pp. 10-16 ◽  
Author(s):  
Tetiana Krupodorova ◽  
Victor Barshteyn ◽  
Elena Pokas
Keyword(s):  
Antibacterial Activity ◽  
Antimicrobial Agents ◽  
Multidrug Resistant ◽  
Inhibitory Effect ◽  
Clinical Isolates ◽  
Bacterial Strains ◽  
Bacterial Diseases ◽  
E Coli ◽  
Pharmaceutical Industries ◽  
Fomitopsis Betulina

The antibacterial activity of Fomitopsis betulina cultural liquid (native, native concentrated, lyophilized, dried) against standard bacteria (Escherichia coli АТСС 25922, Pseudomonas aeruginosa АТСС 27853, Staphylococcus aureus АТСС 25923), and clinical isolates (Acinetobacter baumannii 50/1496 MBL, A. baumannii 88/2995 MBL, E. coli 116/3196 KPC, Klebsiella pneumoniae 6/509 ESBL, AmpC, KPC, P. aeruginosa 99/3066 MBL, P. aeruginosa 125/3343 MBL, S. haemoliticus 22/824 MRSA, S. aureus 134/3569 MRCNS) has been evaluated by the serial dilutions method. The antibacterial activity of F. betulina against S. haemoliticus and A. baumannii has been found for the first time. All samples of F. betulina cultural liquid demonstrated the inhibitory effect against standard bacterial strains at the minimum bactericidal concentration (MBC) ranging from >2.0 up to 18.75 mg/ml, and against multidrug-resistant clinical isolates with MBC from 7.8 up to 48.42 mg/ml. The dried F. betulina cultural liquid showed the highest antimicrobial activity against standard bacteria and clinical isolates, except A. baumannii 50/1496 MBL, while native concentrated cultural liquid was the most effective against this pathogen. The study showed that the antibacterial activity of the cultural liquid of F. betulina was improved by concentration and drying. The results obtained indicate that F. betulina cultural liquid contains alternative antimicrobial agents, useful for the treatment of bacterial diseases and might be a perspective substance for the pharmaceutical industries

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