scholarly journals The Association Between Sagittal Plane Alignment and Disc Space Narrowing of Lumbar Spine in Farmers

2021 ◽  
Vol 45 (4) ◽  
pp. 294-303
Author(s):  
Ki Hoon Park ◽  
Sora Baek ◽  
Eun Kyoung Kang ◽  
Hee-won Park ◽  
Gowun Kim ◽  
...  
Keyword(s):  
Sagittal Plane ◽  
Lumbar Disc ◽  
Age Groups ◽  
Low Back ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
Lateral Spine ◽  
Spine Radiograph ◽  
Segmental Lordosis ◽  
Disc Level

Objective To investigate whether lumbar lordosis (LL) and lumbar segmental lordosis (LSL) are related to sex, age, low back pain (LBP), and lumbar disc space narrowing (DSN).Methods A total of 569 farmers were recruited. In lateral spine radiograph, LL (L1–L5) and LSL (L1, L2, L3, L4, and L5) were measured using Cobb’s method. The differences in LSL values (ΔLSL) according to the presence or absence of a DSN were calculated as LSLDSN – LSLnoDSN for each DSN level.Results In male, the lateral spine radiograph showed significantly greater L4-LSL and L5-LSL and smaller L1-LSL and L2-LSL compared to female. LLs in the 50–59 and ≥60 years age groups were significantly smaller compared to those in the <50 years age group. In subjects with LBP, LL and L4-LSL were significantly smaller than in those without. The ΔLSLs at the disc level with DSN showed the greatest decrease: L1-ΔLSL (Δ-3.99°), L2-ΔLSL (Δ-3.31°), L3-ΔLSL (Δ-2.87°), L4-ΔLSL (Δ-3.31°), and L5-ΔLSL (Δ-4.44°) in L1/2, L2/3, L3/4, L4/5, and L5/S1 DSN, respectively. Conversely, distant ΔLSLs were inversely increased: L1-LSL (Δ0.75°) with L4/5 DSN and L2-LSL (Δ0.94°) with L5/S1 DSN.Conclusion Sagittal plane alignment was significantly associated with sex, age, LBP, and DSN. LSLs around the levels of DSN were decreased, and there was compensational increase of LSL distant to the DSN to maintain the overall LL.

scholarly journals Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

2012 ◽  
Vol 72 (7) ◽  
pp. 1141-1148 ◽  
Author(s):  
Frances M K Williams ◽  
Aruna T Bansal ◽  
Joyce B van Meurs ◽  
Jordana T Bell ◽  
Ingrid Meulenbelt ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Disc Degeneration ◽  
Lumbar Disc ◽  
Meta Analysis ◽  
Low Back ◽  
Lumbar Disc Degeneration ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
Genome Wide

ObjectiveLumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of LDD.MethodsWe have developed a continuous trait based on disc space narrowing and osteophytes growth which is measurable on all forms of imaging (plain radiograph, CT scan and MRI) and performed a meta-analysis of five cohorts of Northern European extraction each having GWA data imputed to HapMap V.2.ResultsThis study of 4600 individuals identified four single nucleotide polymorphisms with p<5×10−8, the threshold set for genome-wide significance. We identified a variant in the PARK2 gene (p=2.8×10−8) associated with LDD. Differential methylation at one CpG island of the PARK2 promoter was observed in a small subset of subjects (β=8.74×10−4, p=0.006).ConclusionsLDD accounts for a considerable proportion of low back pain and the pathogenesis of LDD is poorly understood. This work provides evidence of association of the PARK2 gene and suggests that methylation of the PARK2 promoter may influence degeneration of the intervertebral disc. This gene has not previously been considered a candidate in LDD and further functional work is needed on this hitherto unsuspected pathway.

scholarly journals Neglected alkaptonuric patient presented with low back pain and radiculopathy: A case report

2022 ◽  
Vol 13 ◽  
pp. 15
Author(s):  
Mohammad Moein Vakilzadeh ◽  
Sajjad Saghebdoust ◽  
Bita Abbasi ◽  
Reza Zare
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Urine Specimen ◽  
Low Back ◽  
Connective Tissues ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
Disc Herniations

Background: Alkaptonuria (AKU) is a rare hereditary disorder in which excess homogentisic acid (HGA) deposits in connective tissues (ochronosis). Here, we report the unusual presentation of a lumbar disc herniation occurring in a patient with AKU warranting surgical intervention. Case Description: A 28-year-old male presented with 1 year of low back pain. The lumbar magnetic resonance imaging showed an extruded disc at the L4-L5 level accompanied extensive disc space narrowing and osteophyte formation. At surgery, the interspinous ligaments, facet joints, and disc herniation were black. In addition, the postoperative re-examination revealed a black discoloration of the nasal and ear cartilage. Finally, the diagnosis of AKU was confirmed when the urine specimen was positive for HGA. Conclusion: Rarely, younger patients with AKU who develop excess black deposits of HGA in connective tissues (i.e., ochronosis) may present with lumbar disc herniations and spondylosis.

12:0024. Effect of lumbar disc space narrowing on intervertebral foraminal dimensions

2005 ◽  
Vol 5 (4) ◽  
pp. S12-S13
Author(s):  
Jiayong Liu ◽  
Nabil Ebraheim ◽  
Haitham Elsamaloty ◽  
Nakul Karkare ◽  
Richard Yeasting ◽  
...  
Keyword(s):  
Lumbar Disc ◽  
Disc Space Narrowing ◽  
Disc Space

scholarly journals Lumbar disc degeneration: association between osteophytes, end-plate sclerosis and disc space narrowing

2007 ◽  
Vol 66 (3) ◽  
pp. 330-333 ◽  
Author(s):  
S. R Pye ◽  
D. M Reid ◽  
M. Lunt ◽  
J. E Adams ◽  
A. J Silman ◽  
...  
Keyword(s):  
Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
End Plate

Effect of the Increase in the Height of Lumbar Disc Space on Facet Joint Articulation Area in Sagittal Plane

Spine ◽  
2006 ◽  
Vol 31 (7) ◽  
pp. E198-E202 ◽  
Author(s):  
Jiayong Liu ◽  
Nabil A. Ebraheim ◽  
Steven P. Haman ◽  
Qaiser Shafiq ◽  
Nakul Karkare ◽  
...  
Keyword(s):  
Facet Joint ◽  
Sagittal Plane ◽  
Lumbar Disc ◽  
Disc Space

Prevalence of radiographic lumbar spondylosis and its association with low back pain in elderly subjects of population-based cohorts: the ROAD study

2008 ◽  
Vol 68 (9) ◽  
pp. 1401-1406 ◽  
Author(s):  
S Muraki ◽  
H Oka ◽  
T Akune ◽  
A Mabuchi ◽  
Y En-yo ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Large Scale ◽  
Large Population ◽  
Elderly Subjects ◽  
Low Back ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
Cross Sectional ◽  
Lumbar Spondylosis

Objectives:Although lumbar spondylosis is a major cause of low back pain and disability in elderly people, few epidemiological studies have been performed. The prevalence of radiographic lumbar spondylosis was investigated in a large-scale population study and the association with low back pain was examined.Methods:From a nationwide cohort study (Research on Osteoarthritis Against Disability; ROAD), 2288 participants aged ⩾60 years (818 men and 1470 women) living in urban, mountainous and coastal communities were analysed. The radiographic severity at lumbar intervertebral levels from L1/2 to L5/S was determined by Kellgren/Lawrence (KL) grading.Results:In the overall population the prevalence of radiographic spondylosis with KL⩾2 and ⩾3 at the severest intervertebral level was 75.8% and 50.4%, respectively, and that of low back pain was 28.8%. Although KL⩾2 spondylosis was more prevalent in men, KL⩾3 spondylosis and low back pain were more prevalent in women. Age and body mass index were risk factors for both KL ⩾2 and KL⩾3 spondylosis. Although KL = 2 spondylosis was not significantly associated with low back pain compared with KL = 0 or 1, KL⩾3 spondylosis was related to the pain only in women.Conclusions:This cross-sectional study in a large population revealed a high prevalence of radiographic lumbar spondylosis in elderly subjects. Gender seems to be distinctly associated with KL⩾2 and KL⩾3 lumbar spondylosis, and disc space narrowing with or without osteophytosis in women may be a risk factor for low back pain.

Lumbar Disc Degeneration in Osteoporotic Men: Prevalence and Assessment of the Relation with Presence of Vertebral Fracture

2013 ◽  
Vol 40 (7) ◽  
pp. 1183-1190 ◽  
Author(s):  
Isabelle Fabreguet ◽  
Jacques Fechtenbaum ◽  
Karine Briot ◽  
Simon Paternotte ◽  
Christian Roux
Keyword(s):  
Vertebral Fracture ◽  
Disc Degeneration ◽  
Vertebral Fractures ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
Spine Degeneration ◽  
The Relationship ◽  
Semiquantitative Method

Objective.The relationship between osteoarthritis (OA) and osteoporosis (OP) remains controversial. An inverse relationship between spine OA and the presence of prevalent vertebral fractures has been shown in osteoporotic women. Our objective was to assess this relationship in osteoporotic men.Methods.All the patients had OP based on densitometric data and were aged ≥ 65 years. Spine radiographs were performed according to a standardized procedure. Vertebral fractures were assessed from T4 to L4 by a semiquantitative method. Disc degenerative changes were assessed by the presence and severity of osteophytes and disc narrowing at levels T12–L1 to L5–S1. Logistic regression was used to study the relationship between the presence of vertebral fracture and lumbar disc degeneration.Results.The study included 261 osteoporotic men. The prevalence of vertebral fractures was 26.4% (69/261). At least 1 osteophyte was found in 91.6% (239/261) of patients, and at least 1 disc space narrowing in 63.5% (165/260). The prevalence of at least 1 osteophyte and/or at least 1 disc space narrowing was similar in patients with and those without vertebral fracture. No relationship was found between the presence and/or the severity of osteophytes and disc narrowings and the presence of prevalent vertebral radiographic fractures.Conclusion.In osteoporotic men, the prevalence of lumbar spine degeneration is high. There is no relationship between lumbar disc degeneration and the presence of vertebral fracture in osteoporotic men.

4:34111. Effect of Lumbar Disc Space Narrowing and Retrolisthesis of Vertebra on the Intervertebral Foramen

2006 ◽  
Vol 6 (5) ◽  
pp. 54S-55S
Author(s):  
Jiayong Liu ◽  
Nabil A. Ebraheim ◽  
Matthew Robon ◽  
Chris G. Sanford ◽  
Richard A. Yeasting
Keyword(s):  
Lumbar Disc ◽  
Intervertebral Foramen ◽  
Disc Space Narrowing ◽  
Disc Space
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