scholarly journals A case of Human Parechovirus Infection in an Infant with Meningitis

2021 ◽  
Vol 15 (2) ◽  
pp. 114-116
Author(s):  
Semih Tokak ◽  
Mehmet Özdemir ◽  
Yasemin Derya Gülseren ◽  
Hüseyin Çaksen
Keyword(s):  
Human Parechovirus

Human Parechovirus Infections in Healthy Australian Children During the First 2-Years of Life: A Community-Based Longitudinal Birth Cohort Study

2019 ◽  
Author(s):  
Claire Y. T. Wang ◽  
Robert S. Ware ◽  
Stephen B. Lambert ◽  
Lebogang P. Mhango ◽  
Sarah Tozer ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Human Parechovirus ◽  
Community Based

scholarly journals Isolation and Characterization of Novel Human Parechovirus from Clinical Samples

2007 ◽  
Vol 13 (6) ◽  
pp. 889-895 ◽  
Author(s):  
Kanako Watanabe ◽  
Masayasu Oie ◽  
Masaya Higuchi ◽  
Makoto Nishikawa ◽  
Masahiro Fujii
Keyword(s):  
Clinical Samples ◽  
Human Parechovirus ◽  
Isolation And Characterization

Human parechovirus infection as an undiagnosed cause of adult pericarditis

2017 ◽  
Vol 75 (6) ◽  
pp. 596-597 ◽  
Author(s):  
Thomas McGregor ◽  
Frances A. Bu'Lock ◽  
Martin Wiselka ◽  
Julian W. Tang
Keyword(s):  
Human Parechovirus

scholarly journals Human Parechovirus Infection in Children in Taiwan: a Retrospective, Single-Hospital Study

2018 ◽  
Vol 71 (4) ◽  
pp. 291-297 ◽  
Author(s):  
Jenn-Tzong Chang ◽  
Yao-Shen Chen ◽  
Bao-Chen Chen ◽  
Tsi-Shu Huang ◽  
Tsung-Hsien Chang
Keyword(s):  
Human Parechovirus ◽  
Hospital Study

scholarly journals A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody

2018 ◽  
Vol 93 (4) ◽  
Author(s):  
Aušra Domanska ◽  
Justin W. Flatt ◽  
Joonas J. J. Jukonen ◽  
James A. Geraets ◽  
Sarah J. Butcher
Keyword(s):  
Electron Microscopy ◽  
Monoclonal Antibody ◽  
High Resolution ◽  
Cultured Cells ◽  
Human Monoclonal Antibody ◽  
Neutralizing Antibody ◽  
Molecular Diagnostic ◽  
Diagnostic Tools ◽  
Human Parechovirus ◽  
Cryo Electron Microscopy

ABSTRACTHuman parechovirus 3 (HPeV3) infection is associated with sepsis characterized by significant immune activation and subsequent tissue damage in neonates. Strategies to limit infection have been unsuccessful due to inadequate molecular diagnostic tools for early detection and the lack of a vaccine or specific antiviral therapy. Toward the latter, we present a 2.8-Å-resolution structure of HPeV3 in complex with fragments from a neutralizing human monoclonal antibody, AT12-015, using cryo-electron microscopy (cryo-EM) and image reconstruction. Modeling revealed that the epitope extends across neighboring asymmetric units with contributions from capsid proteins VP0, VP1, and VP3. Antibody decoration was found to block binding of HPeV3 to cultured cells. Additionally, at high resolution, it was possible to model a stretch of RNA inside the virion and, from this, identify the key features that drive and stabilize protein-RNA association during assembly.IMPORTANCEHuman parechovirus 3 (HPeV3) is receiving increasing attention as a prevalent cause of sepsis-like symptoms in neonates, for which, despite the severity of disease, there are no effective treatments available. Structural and molecular insights into virus neutralization are urgently needed, especially as clinical cases are on the rise. Toward this goal, we present the first structure of HPeV3 in complex with fragments from a neutralizing monoclonal antibody. At high resolution, it was possible to precisely define the epitope that, when targeted, prevents virions from binding to cells. Such an atomic-level description is useful for understanding host-pathogen interactions and viral pathogenesis mechanisms and for finding potential cures for infection and disease.

scholarly journals PS-305 Human Parechovirus 3 As A Cause Of Neonatal Infection

2014 ◽  
Vol 99 (Suppl 2) ◽  
pp. A221.3-A222
Author(s):  
A Cilla ◽  
J Arnaez ◽  
J Suarez ◽  
G Megias ◽  
P Alamillo ◽  
...  
Keyword(s):  
Neonatal Infection ◽  
Human Parechovirus

Human parechovirus causes encephalitis with white matter injury in neonates

2008 ◽  
Vol 64 (3) ◽  
pp. 266-273 ◽  
Author(s):  
Malgorzata A. Verboon-Maciolek ◽  
Floris Groenendaal ◽  
Cecil D. Hahn ◽  
Jonathan Hellmann ◽  
Anton M. van Loon ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Injury ◽  
Human Parechovirus
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