Atypical presentation of optic neuritis with unilateral inferior altitudinal visual field defect in multiple sclerosis

Purpose: We report a case of optic neuritis related to infliximab treatment in a patient with Crohn’s disease, along with a review of the relevant literature.Case summary: A 22-year-male patient complained of blurred vision in the left eye for 2-3 weeks. His best-corrected visual acuity was 8/20 in the left eye. Relative afferent pupillary defect was detected in the left eye and the pupils were of equal size. There was no pain on ocular movement. The results of slit-lamp and fundus examinations were normal. A visual field test revealed a central to inferior visual field defect in the left eye. Orbit magnetic resonance imaging revealed perineural enhancement of the left optic nerve. He had a 5-year history of Crohn’s disease and had been treated with intravenous infliximab (600 mg every 2 weeks). A diagnosis of retrobulbar optic neuritis associated with infliximab was made. He was infused with high-dose methylprednisolone, which was changed to per oral administration. His visual acuity and visual field defect improved after 3 months.Conclusions: Tumor necrosis factor-α inhibitors, such as infliximab, may cause optic neuritis. Therefore, history-taking is important for differential diagnosis and appropriate treatment.

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Unilateral Acute Idiopathic Optic Neuritis With Superior Altitudinal Visual Field Defect as a Presenting Feature

Cureus ◽

10.7759/cureus.17011 ◽

2021 ◽

Author(s):

Ali Anwar Abro ◽

Aysha Falamarzi ◽

Mohamed Yusuf Shaikh

Keyword(s):

Visual Field ◽

Optic Neuritis ◽

Visual Field Defect ◽

Field Defect

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Optic Neuritis with Visual Field Defect—Possible Ibuprofen-Related Toxicity

Annals of Pharmacotherapy ◽

10.1345/aph.1g451 ◽

2006 ◽

Vol 40 (3) ◽

pp. 571-573 ◽

Cited By ~ 12

Author(s):

Maria-A Gamulescu ◽

Berthold Schalke ◽

Gerhard Schuierer ◽

Veit-P Gabel

Keyword(s):

Visual Field ◽

Optic Neuritis ◽

Visual Field Defect ◽

Field Defect

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Optic Neuritis Presenting With Altitudinal Visual Field Defect in a Neuromyelitis Optica Patient

Journal of Neurology Research ◽

10.14740/jnr463w ◽

2017 ◽

Vol 7 (6) ◽

pp. 112-114

Author(s):

Halil Onder ◽

Farid Khasiyev ◽

Rana Karabudak

Keyword(s):

Visual Field ◽

Optic Neuritis ◽

Neuromyelitis Optica ◽

Visual Field Defect ◽

Field Defect

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Diffusion Tensor Imaging in Cases With Visual Field Defect After Anterior Temporal Lobectomy

Yearbook of Ophthalmology ◽

10.1016/s0084-392x(08)70377-0 ◽

2006 ◽

Vol 2006 ◽

pp. 208-211

Author(s):

A.E. Flanders

Keyword(s):

Diffusion Tensor Imaging ◽

Visual Field ◽

Visual Field Defect ◽

Diffusion Tensor ◽

Temporal Lobectomy ◽

Anterior Temporal Lobectomy ◽

Field Defect

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Visual Field Examination in Glaucoma Patients : Humphrey Visual Field Analysis vs Amsler Grid

Ophthalmologica Indonesiana ◽

10.35749/journal.v43i2.152 ◽

2017 ◽

Vol 43 (2) ◽

pp. 124

Author(s):

Ivana Tanoko ◽

Fifin L Rahmi

Keyword(s):

Visual Field ◽

Visual Field Defect ◽

Glaucoma Patient ◽

Field Analysis ◽

Glaucomatous Optic Neuropathy ◽

Visual Field Examination ◽

Cross Sectional ◽

Rnfl Thickness ◽

Amsler Grid ◽

Field Defect

Introduction and Objective: Glaucoma is the leading cause of global irreversible blindness, signed by glaucomatous optic neuropathy related to visual field defect. The purpose of the study is comparing visual field defect examination using HVFA to Amsler Grid in glaucoma patient at dr. Kariadi Hospital. Methods: This is a cross-sectional study. Amsler Grid were performed to the patients who have reliable HVFA at last 6 months and presented as descriptive analytic results. Result: There were 40 eyes involved in this study from 27 patients (15 men, 12 women), 26-68 years old and visual acuity 1/60-6/6. Seventeen eyes showed visual field defect in HVFA and Amsler Grid had average MD - 24.97 dB, CDR 0.89 and RNFL thickness 51.74. We found that 11 eyes didn’t showed in both of examination had average MD -8.06, CDR 0.63 and RNFL thickness 103.23 and those parameters are significantly different to the 17 eyes before (p<0.05). Data from 12 eyes that showed visual field defect only one of examination (9 only in HVFA and 3 in Amsler Grid) didn’t show difference statistically each other. Conclusion: HFVA and Amsler Grid seemed to be comparable in detecting visual field defect in advanced glaucoma.

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Acute Zonal Occult Outer Retinopathy: Vision Loss in an Active Duty Soldier

Case Reports in Medicine ◽

10.1155/2013/240607 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5

Author(s):

Courtney M. Crawford ◽

Bruce A. Rivers ◽

Mark Nelson

Keyword(s):

Visual Field ◽

Visual Field Defect ◽

Vision Loss ◽

Fundus Autofluorescence ◽

Final Diagnosis ◽

Active Duty ◽

Visual Field Defects ◽

Fundus Photographs ◽

Optical Coherence Tomograph ◽

Field Defect

Objective. To describe a case of acute zonal occult outer retinopathy (AZOOR) in an active duty patient.Methods. In this paper we studied fundus photographs, optical coherence tomograph, Humphrey visual field 30-2, fundus autofluorescence images, fluorescein angiograms, and electroretinography.Results. Exam findings on presentation: a 34-year-old American Indian female presented with bilateral photopsias, early RPE irregularity, and an early temporal visual field defect. Progression RPE damage and visual field defect along with ERG findings support final diagnosis of AZOOR.Conclusion. AZOOR may initially be identified as a broader category of disease called the “AZOOR complex of disorders”. Specific visual field defects, ERG results, and clinical exam findings will help distinguish AZOOR from other similar disorders.

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Association of ocular blood flow and contrast sensitivity in normal tension glaucoma

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05235-8 ◽

2021 ◽

Author(s):

David Kuerten ◽

Matthias Fuest ◽

Peter Walter ◽

Babac Mazinani ◽

Niklas Plange

Keyword(s):

Blood Flow ◽

Visual Field ◽

Contrast Sensitivity ◽

Visual Field Defect ◽

Prospective Trial ◽

Normal Tension Glaucoma ◽

Ocular Blood Flow ◽

Retinal Blood Flow ◽

Control Group ◽

Field Defect

Abstract Purpose To investigate the relationship of ocular blood flow (via arteriovenous passage time, AVP) and contrast sensitivity (CS) in healthy as well as normal tension glaucoma (NTG) subjects. Design Mono-center comparative prospective trial Methods Twenty-five NTG patients without medication and 25 healthy test participants were recruited. AVP as a measure of retinal blood flow was recorded via fluorescein angiography after CS measurement using digital image analysis. Association of AVP and CS at 4 spatial frequencies (3, 6, 12, and 18 cycles per degree, cpd) was explored with correlation analysis. Results Significant differences regarding AVP, visual field defect, intraocular pressure, and CS measurement were recorded in-between the control group and NTG patients. In NTG patients, AVP was significantly correlated to CS at all investigated cpd (3 cpd: r = − 0.432, p< 0.03; 6 cpd: r = − 0.629, p< 0.0005; 12 cpd: r = − 0.535, p< 0.005; and 18 cpd: r = − 0.58, p< 0.001), whereas no significant correlations were found in the control group. Visual acuity was significantly correlated to CS at 6, 12, and 18 cpd in NTG patients (r = − 0.68, p< 0.002; r = − 0.54, p< .02, and r = − 0.88, p< 0.0001 respectively), however not in healthy control patients. Age, visual field defect MD, and PSD were not significantly correlated to CS in in the NTG group. MD and PSD were significantly correlated to CS at 3 cpd in healthy eyes (r = 0.55, p< 0.02; r = − 0.47, p< 0.03). Conclusion Retinal blood flow alterations show a relationship with contrast sensitivity loss in NTG patients. This might reflect a disease-related link between retinal blood flow and visual function. This association was not recorded in healthy volunteers.

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