PHYSIOLOGICAL AND LEUKOCYTE SUBSET RESPONSES TO EXERCISE AND COLD EXPOSURE IN COLD-ACCLIMATIZED SKATERS

The effects, on the body temperature of white mice, of repeated short exposures to cold were investigated using two methods of restraint. Animals held in a flattened posture became hypothermic at room temperature, cooled more than five times as fast at −10 °C as mice that could adopt a heat-conserving posture, and continued to cool for some time after they were removed from the cold. With repeated tests, cooling at room temperature decreased, and an improvement in re warming ability was observed. In addition, with lightly restrained mice, the fall in rectal temperature during cold exposure showed a progressive decrease, a phenomenon not observed with severely restrained animals.

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Early Cold Exposure: Effects on Behavioral and Physiological Thermoregulation in the House Mouse, Mus musculus

Physiological Zoology ◽

10.1086/physzool.49.2.30152539 ◽

1976 ◽

Vol 49 (2) ◽

pp. 191-199 ◽

Cited By ~ 15

Author(s):

G. Robert Lynch ◽

Carol Becker Lynch ◽

Marjory Dube ◽

Cynthia Allen

Keyword(s):

House Mouse ◽

Cold Exposure ◽

Mus Musculus

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Cold-induction of afadin in brown fat supports its thermogenic capacity

Scientific Reports ◽

10.1038/s41598-021-89207-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Morten Lundh ◽

Ali Altıntaş ◽

Marco Tozzi ◽

Odile Fabre ◽

Tao Ma ◽

...

Keyword(s):

Cold Exposure ◽

Functional Enrichment ◽

Activation Process ◽

Target Tissue ◽

Cold Stimulation ◽

Brown Adipocytes ◽

Protein Levels ◽

Mrna Induction ◽

Metabolic Functions ◽

Brown Adipose

AbstractThe profound energy-expending nature of brown adipose tissue (BAT) thermogenesis makes it an attractive target tissue to combat obesity-associated metabolic disorders. While cold exposure is the strongest inducer of BAT activity, the temporal mechanisms tuning BAT adaptation during this activation process are incompletely understood. Here we show that the scaffold protein Afadin is dynamically regulated by cold in BAT, and participates in cold acclimation. Cold exposure acutely increases Afadin protein levels and its phosphorylation in BAT. Knockdown of Afadin in brown pre-adipocytes does not alter adipogenesis but restricts β3-adrenegic induction of thermogenic genes expression and HSL phosphorylation in mature brown adipocytes. Consistent with a defect in thermogenesis, an impaired cold tolerance was observed in fat-specific Afadin knockout mice. However, while Afadin depletion led to reduced Ucp1 mRNA induction by cold, stimulation of Ucp1 protein was conserved. Transcriptomic analysis revealed that fat-specific ablation of Afadin led to decreased functional enrichment of gene sets controlling essential metabolic functions at thermoneutrality in BAT, whereas it led to an altered reprogramming in response to cold, with enhanced enrichment of different pathways related to metabolism and remodeling. Collectively, we demonstrate a role for Afadin in supporting the adrenergic response in brown adipocytes and BAT function.

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Occupational cold exposure is associated with increased reporting of airway symptoms

International Archives of Occupational and Environmental Health ◽

10.1007/s00420-021-01694-y ◽

2021 ◽

Author(s):

Albin Stjernbrandt ◽

Nikolai Stenfors ◽

Ingrid Liljelind

Keyword(s):

Cold Exposure ◽

Leisure Time ◽

Rating Scales ◽

Binary Logistic Regression ◽

Population Based ◽

Postal Survey ◽

Chronic Obstructive ◽

Northern Sweden ◽

Obstructive Pulmonary Disease ◽

Airway Symptoms

Abstract Objective To determine if exposure to cold environments, during work or leisure time, was associated with increased reporting of airway symptoms in the general population of northern Sweden. Methods Through a population-based postal survey responded to by 12627 subjects, ages 18–70, living in northern Sweden, the occurrence of airway symptoms was investigated. Cold exposure during work or leisure time was self-reported on numerical rating scales. Binary logistic regression was used to determine the statistical association between cold exposure and airway symptoms. Results For currently working subjects (N = 8740), reporting any occupational cold exposure was associated to wheeze (OR 1.3; 95% CI 1.1–1.4); chronic cough (OR 1.2; 95% CI 1.1–1.4); and productive cough (OR 1.3; 95% CI 1.1–1.4), after adjusting for gender, age, body mass index, daily smoking, asthma, and chronic obstructive pulmonary disease. Leisure-time cold exposure was not significantly associated to reporting airway symptoms. Conclusions Occupational cold exposure was an independent predictor of airway symptoms in northern Sweden. Therefore, a structured risk assessment regarding cold exposure could be considered for inclusion in the Swedish workplace legislation.

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