scholarly journals Targeted Memory Reactivation During Slow Wave Sleep Facilitates Emotional Memory Consolidation

SLEEP ◽  
2014 ◽  
Vol 37 (4) ◽  
pp. 701-707 ◽  
Author(s):  
Scott A. Cairney ◽  
Simon J. Durrant ◽  
Johan Hulleman ◽  
Penelope A. Lewis
Keyword(s):  
Slow Wave ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Emotional Memory ◽  
Memory Reactivation

scholarly journals 0086 Targeted Memory Reactivation during Slow-Wave Sleep Modulates the Neural Correlates of Emotional Memory and Arousal Processing in Women

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A35-A36
Author(s):  
Maria-Efstratia Tsimpanouli ◽  
Isabel C Hutchison ◽  
Martyn McFarquhar ◽  
Rebecca Elliott ◽  
Jules Schneider ◽  
...  
Keyword(s):  
Slow Wave ◽  
Slow Wave Sleep ◽  
Neural Correlates ◽  
Emotional Memory ◽  
Memory Reactivation

scholarly journals 0109 Slow Wave Sleep Time and Its Oscillatory Features Show Opposite Associations with Emotional Memory Consolidation Following Stress

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A43-A43
Author(s):  
D Denis ◽  
S Y Kim ◽  
S M Kark ◽  
R T Daley ◽  
S E Alger ◽  
...  
Keyword(s):  
Slow Wave ◽  
Memory Consolidation ◽  
Social Stress ◽  
Slow Wave Sleep ◽  
Sleep Stage ◽  
Sleep Time ◽  
Emotional Memory ◽  
Oscillatory Activity ◽  
National Science Foundation Grant ◽  
Stress Group

Abstract Introduction Sleep and stress can both enhance emotional memory consolidation. During slow wave sleep (SWS), oscillatory features such as slow oscillations (SO), sleep spindles (SS), and critically, their coupling, are believed to facilitate consolidation. How they relate to emotional memory consolidation is less clear, and how stress interacts with these oscillations is unknown. Methods In this study, participants either underwent a psychosocial stressor (the Trier Social Stress Task; n = 32) or a control task (n=32). Next, they encoded 150 neutral, negative, and positive images while undergoing fMRI. Participants then spent the night in the lab with polysomnographic recording. The next day they were given a surprise recognition test. Results There was better memory for emotional compared to neutral items in the stress group. Within this group, % of time spent in SWS positively correlated with emotional memory consolidation (r=.37, p=.039). However, SO-SS coupling during SWS was negatively correlated with emotional memory consolidation in the stress group (r=-.47, p=.007). This was driven by participants who showed a high cortisol response following the stressor (cortisol * coupling interaction p=.03) Results were similar when negative and positive items were analyzed separately. No correlations with neutral item memory were found. Conclusion Sleep stage time and sleep oscillatory activity exert different effects on emotional memory following stress, and that SO-SS coupling does not always promote episodic memory consolidation. SO-SS coupling can impair emotional memories when encoded during periods of elevated stress, and accompanying neuromodulators such as cortisol are high. Support National Science Foundation, Grant/Award Number: BXS-1539361

scholarly journals Cued reactivation during slow-wave sleep induces connectivity changes related to memory stabilization

2017 ◽  
Author(s):  
Ruud M.W.J. Berkers ◽  
Matthias Ekman ◽  
Eelco V. van Dongen ◽  
Atsuko Takashima ◽  
Marcus Barth ◽  
...  
Keyword(s):  
Slow Wave ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Occipital Cortex ◽  
Brain Network ◽  
Parahippocampal Gyrus ◽  
Visual Object ◽  
Network Integration ◽  
Retrieval Task ◽  
Memory Reactivation

AbstractMemory reprocessing following acquisition enhances memory consolidation. Specifically, neural activity during encoding is thought to be ‘replayed’ during subsequent slow-wave sleep (SWS). This natural tendency of memory replay can be induced by external cueing, known as “targeted memory reactivation”. Here, we analyzed data from a published study (van Dongen, Takashima, et al. 2012), where auditory cues reactivated learned visual object-location memories during SWS. Memory replay during sleep presumably involves a shift in connectivity across the brain. Therefore, we characterized the effects of memory reactivation on brain network connectivity using graph-theory. We found that cue presentation during SWS introduced increased network integration of the occipital cortex, a visual region that was also active during the object retrieval task. Importantly, enhanced network integration of the occipital cortex showed a behavioural benefit and predicted overnight memory stabilization. Furthermore, occipital cortex displayed enhanced connectivity with mnemonic regions, namely the hippocampus, parahippocampal gyrus, thalamus and medial prefrontal cortex during cue versus control sound presentation. Finally, network integration of early occipital cortex during cueing in SWS was related to increased activation of the bilateral parahippocampal gyrus, a region involved in coding for spatial associative information, at the post-sleep test. Together, these results support a neural mechanism where cue-induced replay during sleep promotes memory consolidation by increased integration of task-relevant perceptual regions with mnemonic regions.

scholarly journals Sleep’s impact on emotional memory: A meta-analysis of whole-night, nap, and REM sleep effects

2019 ◽  
Author(s):  
Sarah K. Schäfer ◽  
Benedikt E. Wirth ◽  
Marlene Staginnus ◽  
Nicolas Becker ◽  
Tanja Michael ◽  
...  
Keyword(s):  
Eye Movement ◽  
Slow Wave ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Meta Analysis ◽  
Emotional Memory ◽  
Sleep Stages ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Neutral Material

SummaryNumerous studies have shown that sleep enhances the consolidation of episodic memory. However, it remains unclear whether this consolidation benefit is moderated by the emotional valence of the learned material. To clarify whether sleep selectively enhances the consolidation of emotional material, we conducted a meta-analysis including N = 1,059 observations. Overall, our results do not support this hypothesis. When only studies with a sleep-group wake-group comparison were included in the analysis (k = 22), the retention advantage for emotional over neutral material was not significantly different between sleep and wake groups. When studies initially lacking a wake-control group were included in the analysis after statistical estimation of wake-group parameters, the retention advantage for emotional material was significantly larger in wake-groups than in sleep-groups (k = 34). Interestingly, however, an additional analysis of k = 8 studies investigating the selective effects of rapid-eye-movement sleep and slow-wave sleep on emotional memory consolidation provided evidence for a selective enhancement of emotional over neutral memory consolidation after rapid-eye-movement sleep compared to slow-wave sleep. These results suggest that sleep does not generally enhance emotional memory consolidation over neutral memory consolidation. However, specific sleep stages might preferentially enhance consolidation of emotional and neutral material, respectively.

scholarly journals Bi-Temporal Anodal Transcranial Direct Current Stimulation during Slow-Wave Sleep Boosts Slow-Wave Density but Not Memory Consolidation

2021 ◽  
Vol 11 (4) ◽  
pp. 410
Author(s):  
Simon Ruch ◽  
Kristoffer Fehér ◽  
Stephanie Homan ◽  
Yosuke Morishima ◽  
Sarah Maria Mueller ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Slow Wave ◽  
Direct Current ◽  
Memory Consolidation ◽  
Transcranial Direct Current Stimulation ◽  
Slow Wave Sleep ◽  
Memory Performance ◽  
Direct Current Stimulation ◽  
Sleep Parameters ◽  
Episodic Memories

Slow-wave sleep (SWS) has been shown to promote long-term consolidation of episodic memories in hippocampo–neocortical networks. Previous research has aimed to modulate cortical sleep slow-waves and spindles to facilitate episodic memory consolidation. Here, we instead aimed to modulate hippocampal activity during slow-wave sleep using transcranial direct current stimulation in 18 healthy humans. A pair-associate episodic memory task was used to evaluate sleep-dependent memory consolidation with face–occupation stimuli. Pre- and post-nap retrieval was assessed as a measure of memory performance. Anodal stimulation with 2 mA was applied bilaterally over the lateral temporal cortex, motivated by its particularly extensive connections to the hippocampus. The participants slept in a magnetic resonance (MR)-simulator during the recordings to test the feasibility for a future MR-study. We used a sham-controlled, double-blind, counterbalanced randomized, within-subject crossover design. We show that stimulation vs. sham significantly increased slow-wave density and the temporal coupling of fast spindles and slow-waves. While retention of episodic memories across sleep was not affected across the entire sample of participants, it was impaired in participants with below-average pre-sleep memory performance. Hence, bi-temporal anodal direct current stimulation applied during sleep enhanced sleep parameters that are typically involved in memory consolidation, but it failed to improve memory consolidation and even tended to impair consolidation in poor learners. These findings suggest that artificially enhancing memory-related sleep parameters to improve memory consolidation can actually backfire in those participants who are in most need of memory improvement.

scholarly journals Targeted memory reactivation in REM but not SWS selectively reduces arousal responses

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Isabel C. Hutchison ◽  
Stefania Pezzoli ◽  
Maria-Efstratia Tsimpanouli ◽  
Mahmoud E. A. Abdellahi ◽  
Penelope A. Lewis
Keyword(s):  
Slow Wave Sleep ◽  
Sleep Stage ◽  
Emotional Memory ◽  
Rapid Eye Movement Sleep ◽  
Emotional Experiences ◽  
Memory Reactivation ◽  
Emotional Memories ◽  
The Impact ◽  
Subjective Arousal ◽  
Spontaneous Reactivation

AbstractA growing body of evidence suggests that sleep can help to decouple the memory of emotional experiences from their associated affective charge. This process is thought to rely on the spontaneous reactivation of emotional memories during sleep, though it is still unclear which sleep stage is optimal for such reactivation. We examined this question by explicitly manipulating memory reactivation in both rapid-eye movement sleep (REM) and slow-wave sleep (SWS) using targeted memory reactivation (TMR) and testing the impact of this manipulation on habituation of subjective arousal responses across a night. Our results show that TMR during REM, but not SWS significantly decreased subjective arousal, and this effect is driven by the more negative stimuli. These results support one aspect of the sleep to forget, sleep to remember (SFSR) hypothesis which proposes that emotional memory reactivation during REM sleep underlies sleep-dependent habituation.

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