scholarly journals Clinical care of children and adolescents with COVID‐19: recommendations from the National COVID‐19 Clinical Evidence Taskforce

2021 ◽  
Author(s):  
David Fraile Navarro ◽  
Britta Tendal ◽  
David Tingay ◽  
Nan Vasilunas ◽  
Lorraine Anderson ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Clinical Evidence ◽  
Clinical Care

scholarly journals Clinical characterization of children and adolescents with NF1 microdeletions

2020 ◽  
Vol 36 (10) ◽  
pp. 2297-2310 ◽  
Author(s):  
Hildegard Kehrer-Sawatzki ◽  
Lan Kluwe ◽  
Johannes Salamon ◽  
Lennart Well ◽  
Said Farschtschi ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Developmental Delay ◽  
Clinical Care ◽  
Severe Disease ◽  
Autism Spectrum ◽  
Whole Body ◽  
Global Developmental Delay ◽  
Disease Manifestation ◽  
Tumour Load ◽  
The Mean

Abstract Purpose An estimated 5–11% of patients with neurofibromatosis type 1 (NF1) harbour NF1 microdeletions encompassing the NF1 gene and its flanking regions. The purpose of this study was to evaluate the clinical phenotype in children and adolescents with NF1 microdeletions. Methods We retrospectively analysed 30 children and adolescents with NF1 microdeletions pertaining to externally visible neurofibromas. The internal tumour load was determined by volumetry of whole-body magnetic resonance imaging (MRI) in 20 children and adolescents with NF1 microdeletions. Furthermore, the prevalence of global developmental delay, autism spectrum disorder and attention deficit hyperactivity disorder (ADHD) were evaluated. Results Children and adolescents with NF1 microdeletions had significantly more often cutaneous, subcutaneous and externally visible plexiform neurofibromas than age-matched patients with intragenic NF1 mutations. Internal neurofibromas were detected in all 20 children and adolescents with NF1 microdeletions analysed by whole-body MRI. By contrast, only 17 (61%) of 28 age-matched NF1 patients without microdeletions had internal tumours. The total internal tumour load was significantly higher in NF1 microdeletion patients than in NF1 patients without microdeletions. Global developmental delay was observed in 28 (93%) of 30 children with NF1 microdeletions investigated. The mean full-scale intelligence quotient in our patient group was 77.7 which is significantly lower than that of patients with intragenic NF1 mutations. ADHD was diagnosed in 15 (88%) of 17 children and adolescents with NF1 microdeletion. Furthermore, 17 (71%) of the 24 patients investigated had T-scores ≥ 60 up to 75, indicative of mild to moderate autistic symptoms, which are consequently significantly more frequent in patients with NF1 microdeletions than in the general NF1 population. Also, the mean total T-score was significantly higher in patients with NF1 microdeletions than in the general NF1 population. Conclusion Our findings indicate that already at a very young age, NF1 microdeletions patients frequently exhibit a severe disease manifestation which requires specialized long-term clinical care.

scholarly journals Incorporating genetic counseling into clinical care for children and adolescents with cancer

2016 ◽  
Vol 12 (7) ◽  
pp. 883-886 ◽  
Author(s):  
Jessica N Everett ◽  
Rajen J Mody ◽  
Elena M Stoffel ◽  
Arul M Chinnaiyan
Keyword(s):  
Genetic Counseling ◽  
Children And Adolescents ◽  
Clinical Care

Risk Factors for Dystonia after Selective Dorsal Rhizotomy in Nonwalking Children and Adolescents with Bilateral Spasticity

2017 ◽  
Vol 49 (01) ◽  
pp. 044-050 ◽  
Author(s):  
R. Vermeulen ◽  
Charlotte van 't Westende ◽  
Petra van Schie ◽  
Eline Bolster ◽  
Pim van Ouwerkerk ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Clinical Evidence ◽  
Brain Mri ◽  
Congenital Disorder ◽  
Selective Dorsal Rhizotomy ◽  
Dorsal Rhizotomy ◽  
Chi Squared ◽  
Selection Of Patients ◽  
Selection Of

AbstractWe recently showed a beneficial effect of selective dorsal rhizotomy (SDR) on daily care and comfort in nonwalking children with severe bilateral spasticity. However, despite careful selection, some patients showed dystonia after the intervention, in which cases caregivers tended to be less satisfied with the result.The aim of this study is to identify risk factors for dystonia after SDR in children and adolescents with severe bilateral spasticity (GMFCS levels IV/V).Clinical and MRI risk factors for dystonia after SDR were studied in our cohort of 24 patients. Patients with clinical evidence of dystonia and brain MRI showing basal ganglia abnormalities were excluded for SDR.Nine of 24 patients (38%) showed some degree of dystonia after SDR. There was a significant association between the cause of spasticity and dystonia after SDR; in six (67%) patients with a congenital disorder, dystonia was present versus three (20%) with an acquired disorder (Chi-squared test: C(1) = 5.23, p = 0.02).This study allows more optimal selection of patients that may benefit from SDR. Patients with an acquired cause of spasticity, when selected carefully on clinical examination and MRI, rarely show dystonia after SDR. However, patients with an underlying congenital disorder have a considerable risk of dystonia after SDR.

Childhood and Adolescence

2017 ◽  
Author(s):  
Suad Kapetanovic ◽  
Lori Wiener ◽  
Lisa Tuchman ◽  
Maryland Pao
Keyword(s):  
Mental Health ◽  
Children And Adolescents ◽  
Mental Health Professionals ◽  
Clinical Care ◽  
Health Needs ◽  
Childhood And Adolescence ◽  
Mental Health Needs ◽  
The Family ◽  
Health Objectives ◽  
Hiv Aids

Mental health professionals need to understand how the psychosocial and mental health needs of HIV-infected youth evolve over time and to be able to identify salient clinical challenges that present with each developmental stage. It is also important to understand that HIV/AIDS affects children’s lives indirectly, by the presence of HIV/AIDS in a family member, even if the child is not HIV infected. This chapter uses a developmental perspective to introduce key mental health objectives in the lives of developing HIV-infected children and adolescents and provides an overview of epidemiological, psychosocial, and clinical parameters to be considered in their clinical care and management. The chapter also addresses issues facing perinatally and behaviorally HIV-infected children and adolescents. Separate sections of the chapter discuss biopsychosocial factors salient to children and adolescents who are affected by HIV infection in the family.

The Role of Gender and Culture in Treating Youth With Anxiety Disorders

2006 ◽  
Vol 20 (3) ◽  
pp. 301-310 ◽  
Author(s):  
Holly Harmon ◽  
Audra Langley ◽  
Golda S. Ginsburg
Keyword(s):  
Children And Adolescents ◽  
Behavioral Treatment ◽  
Clinical Care ◽  
Cultural Beliefs ◽  
Symptom Expression ◽  
Cognitive Behavioral Treatment ◽  
Case Examples ◽  
Cultural Variations ◽  
The Impact ◽  
Diverse Cultures

The purpose of this article is to discuss the complexities of working with anxious children and adolescents of diverse cultures within the context of cognitive-behavioral treatment. Our discussion will examine how culture, gender, and minority status affect anxious symptomatology in children and adolescents and how this may be addressed in treatment. The authors discuss the importance of considering the cultural variations in symptom expression, cultural norms and issues of acculturation, effects of discrimination, and finally the ways that gender can moderate symptom expression. Case examples are incorporated into each section. Recommendations include an emphasis on research on working with children of diverse cultures and the need for ongoing training that helps therapists to examine the impact of their own cultural beliefs on clinical care.

Sign in / Sign up

Export Citation Format

Share Document