scholarly journals Estrogen receptor β (ERβ) induces bovine ovarian granulosa cell (BGC) autophagy via the AKT/mTOR pathway

2020 ◽  
Author(s):  
Yuxin Zheng ◽  
Ning Liu ◽  
Xiaorong Tang ◽  
Zhongliang Jiang
Keyword(s):  
Estrogen Receptor ◽  
Granulosa Cell ◽  
Mtor Pathway ◽  
Estrogen Receptor Β ◽  
Ovarian Granulosa Cell

Biguanides inhibit proliferation and decrease estrogen receptor expression in ovarian granulosa cell tumors

2014 ◽  
Vol 133 ◽  
pp. 163-164
Author(s):  
A.L. Jackson ◽  
J. Kilgore ◽  
H. Qiu ◽  
C. Zhou ◽  
P.A. Gehrig ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Granulosa Cell ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Granulosa Cell Tumors ◽  
Ovarian Granulosa Cell

scholarly journals The G-Protein Coupled Estrogen Receptor (GPER/GPR30) in ovarian granulosa cell tumors

2014 ◽  
Vol 74 (S 01) ◽  
Author(s):  
S Heublein ◽  
K Ebinger ◽  
D Mayr ◽  
K Friese ◽  
U Jeschke ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Granulosa Cell ◽  
Granulosa Cell Tumors ◽  
Ovarian Granulosa Cell ◽  
G Protein Coupled

scholarly journals Granulosa cell genes that regulate ovarian follicle development beyond the antral stage: the role of estrogen receptor β

2021 ◽  
pp. 111212
Author(s):  
V. Praveen Chakravarthi ◽  
Anamika Ratri ◽  
Saeed Masumi ◽  
Shaon Borosha ◽  
Subhra Ghosh ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Granulosa Cell ◽  
Ovarian Follicle ◽  
Estrogen Receptor Β ◽  
Follicle Development ◽  
Ovarian Follicle Development

scholarly journals Estrogen Receptor β Is Required for Optimal cAMP Production in Mouse Granulosa Cells

2009 ◽  
Vol 23 (7) ◽  
pp. 955-965 ◽  
Author(s):  
Bonnie J. Deroo ◽  
Karina F. Rodriguez ◽  
John F. Couse ◽  
Katherine J. Hamilton ◽  
Jennifer B. Collins ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cell Differentiation ◽  
Granulosa Cell ◽  
Granulosa Cells ◽  
Regulatory Element ◽  
Estrogen Receptor Β ◽  
Negative Effects ◽  
Camp Pathway ◽  
Element Binding Protein ◽  
Camp Levels

Abstract Granulosa cells of preovulatory follicles differentiate in response to FSH, and this differentiation is augmented by estradiol. We have previously shown that FSH-mediated granulosa cell differentiation requires functional estrogen receptor-β (ERβ) by demonstrating that the granulosa cells of ERβ−/− FSH-treated mice are unable to maximally induce expression of the LH receptor (an indicator of granulosa cell differentiation) compared with ERβ+/+ controls. As a result, FSH-primed ERβ−/− granulosa cells exhibit a reduced response to a subsequent ovulatory dose of LH. In this study, we further characterized the attenuated response of ERβ−/− granulosa cells to stimulation by LH and FSH using isolated mouse granulosa cells and primary granulosa cell cultures. We observed a 50% reduction in cAMP levels in cultured ERβ−/− granulosa cells exposed to LH compared with ERβ+/+ controls. We also observed an attenuated genomic response in granulosa cells isolated from FSH-primed ERβ−/− mice compared with ERβ+/+ controls. Our data indicate that this attenuated response may result from inadequate levels of cAMP, because cAMP levels in cultured ERβ−/− granulosa cells exposed to forskolin were approximately 50% lower than in ERβ+/+ granulosa cells. Phosphorylation of cAMP regulatory element binding protein, an indicator of protein kinase A activity, was also reduced in FSH-treated ERβ−/− granulosa cells compared with ERβ+/+ controls. These are the first data to indicate that ERβ plays a role in the induction of the cAMP pathway in mouse granulosa cells and that disruption of proper ERβ signaling associated with this pathway may cause negative effects on ovulation and fertility.

scholarly journals The G-Protein-Coupled Estrogen Receptor (GPER/GPR30) in Ovarian Granulosa Cell Tumors

2014 ◽  
Vol 15 (9) ◽  
pp. 15161-15172 ◽  
Author(s):  
Sabine Heublein ◽  
Doris Mayr ◽  
Klaus Friese ◽  
Maria Jarrin-Franco ◽  
Miriam Lenhard ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Granulosa Cell ◽  
Granulosa Cell Tumors ◽  
Ovarian Granulosa Cell ◽  
G Protein Coupled

scholarly journals Estrogen receptor β agonist enhances temozolomide sensitivity of glioma cells by inhibiting PI3K/AKT/mTOR pathway

2014 ◽  
Vol 11 (2) ◽  
pp. 1516-1522 ◽  
Author(s):  
XIAOYANG LIU ◽  
LIBO WANG ◽  
JIAJUN CHEN ◽  
QI LING ◽  
HONGFEI WANG ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Glioma Cells ◽  
Mtor Pathway ◽  
Estrogen Receptor Β
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